Related Products of 1515-89-5, A common heterocyclic compound, 1515-89-5, name is 1-Bromo-3-(methoxymethyl)benzene, molecular formula is C8H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of 1-bromo-3-methoxymethyl-benzene. (286 mg, 1.42 MMOL) and bis- (PINACOLATE) DIBORON. (397 mg, 1.56 MMOL) in DMSO (8 mL) are added KOAC (419 mg, 4.27 MMOL) and Pd (DPPF) CI2. CH2CI2 (58 mg, 0.071 MMOL). The reaction mixture is stirred at 80 C under nitrogen atomosphere for 1 h. After dilution with ether, the mixture is washed with water (x2) and brine. The organic layer is dried over MGS04, filtered, and concentrated in vacuo. The residue is purified by silica gel column chromatography (n-hexane: EtOAc=10: 1) to give the corresponding boron ester.
The synthetic route of 1515-89-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GMBH; WO2004/69256; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem