Ethers-buliding-blocks

Enantioselective Synthesis of 1-Aryltetrahydroisoquinolines was written by Wang, Sa;Onaran, M. Burak;Seto, Christopher T.. And the article was included in Organic Letters in 2010.Product Details of 365564-07-4 This article mentions the following:

Chiral N-Boc ethylene diamine ligand I promotes the enantioselective addition of arylzinc reagents to 3,4-dihydroisoquinoline N-oxide to yield (S)-1-aryltetrahydroisoquinolines in 97-99% ee. Pinacol arylboronic esters are the optimal precursors for the arylzinc reagents. This method is applied to the enantioselective synthesis of Solifenacin (II). In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Product Details of 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Product Details of 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fluorinated benzamide neuroleptics – 2. Synthesis and radiosynthesis of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3-[¹⁸F]fluoropropyl)-3-substituted-2-methoxybenzamides was written by Mukherjee, Jogeshwar. And the article was included in Applied Radiation and Isotopes in 1991.Category: ethers-buliding-blocks This article mentions the following:

Synthesis of a fluorinated benzamide neuroleptic (I) starting from 3-(3,4-dimethoxyphenyl)-1-propanol in 20-25% overall yield is reported. Radiosynthesis of II and III was carried out by nucleophilic substitution reaction of (S)-N-[1-ethyl-2-pyrrolidinyl)methyl-5-(3-tosyloxypropyl)-2-methoxybenzamide and (S)-N-[(ethyl-2-pyrrolidinyl)methyl]-5-(3-tosyloxypropyl)-2,3-dimethoxybenzamide resp., with no carrier added [¹⁸F]fluoride. Both, II and III were obtained in approx. 20-30% yields (EOS/EOB, decay corrected). Specific activities of 900-1700 Ci/mmol. for II and 800-1400 Ci/mmol. for III were obtained by reverse phase HPLC purification Total synthesis and purification time required for either II or III was 120 min from EOB. Preferential uptake of III was observed in the striatum region was observed Thus, this compound is a potentially useful ¹⁸F-fluorinated benzamide neuroleptic for imaging dopamine D-2 receptors noninvasively by using PET. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Category: ethers-buliding-blocks).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Iron-catalyzed oxidation of 1-phenylethanol and glycerol with hydrogen peroxide in water medium: effect of the nitrogen ligand on catalytic activity and selectivity was written by Ros, Dimitri;Gianferrara, Teresa;Crotti, Corrado;Farnetti, Erica. And the article was included in Frontiers in Chemistry (Lausanne, Switzerland) in 2020.Quality Control of 2-(2-Methoxyethoxy)ethanol This article mentions the following:

The iron(II) complexes [Fe(bpy)₃](OTf)₂ (bpy = 2,2′-bipyridine; OTf = CF₃SO₃) (1) and [Fe(bpydeg)₃](OTf)₂ (bpydeg = N⁴,N⁴-bis(2-(2-methoxyethoxy)ethyl) [2,2′-bipyridine]-4,4′-dicarboxamide) (2), the latter being a newly synthesized ligand, were employed as catalyst precursors for the oxidation of 1-phenylethanol with hydrogen peroxide in water, using either microwave or conventional heating. With the same oxidant and medium the oxidation of glycerol was also explored in the presence of 1 and 2, as well as of two similar iron(II) complexes bearing tridentate ligands, i.e., [Fe(terpy)₂](OTf)₂ (terpy = 2, 6-di(2-pyridyl)pyridine) (3) and [Fe(bpa)₂](OTf)₂ (bpa = bis(2-pyridinylmethyl)amine) (4): in most reactions the major product formed was formic acid, although with careful tuning of the exptl. conditions significant amounts of dihydroxyacetone were obtained. Addition of heterocyclic amino acids (e.g., picolinic acid) increased the reaction yields of most catalytic reactions. The effect of such additives on the evolution of the catalyst precursors was studied by spectroscopic (NMR, UV-visible) and ESI-MS techniques. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Quality Control of 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Quality Control of 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dihydroconiferyl alcohol as a gibberellin synergist in inducing lettuce hypocotyl elongation. Assessment of structure-activity relationships was written by Shibata, Kozo;Kubota, Takashi;Kamisaka, Seiichiro. And the article was included in Plant and Cell Physiology in 1975.Recommanded Product: 3-(3,4-Dimethoxyphenyl)propan-1-ol This article mentions the following:

Structure-activity relationships of the cotyledon factor were examined by testing the effect of various substances structurally related to the cotyledon factor on gibberellin-induced lettuce hypocotyl elongation. The biol. activity of the cotyledon factor, 3-(4-hydroxy-3-methoxyphenyl) propan-1-ol [2305-13-7], disappeared if the phenolic hydroxy group was masked with a methoxy or glucosyl group. Oxidation of the alc. group in the side chain to a carboxylic group decreased the biol. activity of the cotyledon factor. As to relationships between the biol. activity and length of the alkyl side chain, the propane type was found to be much more active than the methane, ethane or butane type. The presence of a C:C bond in the alkyl side chain made the cotyledon factor biol. inactive. Some antioxidants of indole-3-acetic acid were also assayed for cotyledon factor-like activity, since the cotyledon factor is a polyphenol. However, known antioxidants such as rutin, pyrocatechol, chlorogenic acid, caffeic acid and ferulic acid did not show cotyledon factor-like activity. Structural requirements of the cotyledon factor as a gibberellin synergist were discussed. In the experiment, the researchers used many compounds, for example, 3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3Recommanded Product: 3-(3,4-Dimethoxyphenyl)propan-1-ol).

3-(3,4-Dimethoxyphenyl)propan-1-ol (cas: 3929-47-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 3-(3,4-Dimethoxyphenyl)propan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Palladium- or ruthenium-catalyzed synthesis of 2-phenylindoles was written by Izumi, Taeko;Yokota, Toshiko. And the article was included in Journal of Heterocyclic Chemistry in 1992.Reference of 5367-32-8 This article mentions the following:

Allyl α-phenyl-2-aminophenethyl carbonates I (R = H, R¹ = H, Ph; R = 4-Br, 4-OCH₂Ph, R¹ = Ph) undergo a smooth decarboxylation-dehydrogenation reaction to afford 2-phenylindole derivatives II in acetonitrile at 80° in the presence of palladium complex as catalyst. In the reaction, the ruthenium hydride complex showed more effective catalytic activities. II (R = H, 4-Br, 4-OCH₂Ph, 5-OMe, 4-CO₂Et, 4-SO₂NMe₂, R¹ = Ph) were also prepared from the corresponding α-phenyl-2-aminophenethyl alcs. III and allyl Me carbonate by ruthenium-catalyzed cyclization. In the experiment, the researchers used many compounds, for example, 3-Methyl-4-nitroanisole (cas: 5367-32-8Reference of 5367-32-8).

3-Methyl-4-nitroanisole (cas: 5367-32-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Reference of 5367-32-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and optical characterization of novel azacrown ethers containing an acridinone or an N-methylacridinone unit as potential fluorescent chemosensors was written by Moczar, Ildiko;Huszthy, Peter;Mezei, Andras;Kadar, Mihaly;Nyitrai, Jozsef;Toth, Klara. And the article was included in Tetrahedron in 2010.Safety of 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

Four new achiral and four new chiral monoazacrown ethers containing an acridinone or an N-methylacridinone fluorescent signalling unit were prepared by reacting chloromethyl-substituted acridinone derivatives with achiral monoazacrown ethers with different cavity sizes and enantiopure monoaza-18-crown-6 ethers having two Me and two isoBu groups on their chiral centers, resp. The operation of these chemosensors is based on the photoinduced electron transfer (PET) process, thus they show fluorescence enhancement in the presence of cationic guests. Their fluorescent behavior as well as their complexation properties towards selected metal ions and the enantiomers of α-(1-naphthyl)ethylammonium perchlorate and potassium mandelate were examined In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Safety of 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Safety of 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Journey of a molecule from the solid to the gas phase and vice versa: direct estimation of vapor pressure of alkaline-earth metalorganic precursors for atmospheric pressure vapor phase deposition of fluoride films was written by Lo Presti, Francesca;Pellegrino, Anna L.;Malandrino, Graziella. And the article was included in Dalton Transactions in 2022.Formula: C8H18O4 This article mentions the following:

Atm. pressure (AP) vapor phase processes such as spatial at. layer deposition (S-ALD) and AP-metalorganic chem. vapor deposition (AP-MOCVD) are becoming increasingly appealing for their use in a variety of academic and industrial applications. Evaluation of precursor vapor pressures is crucial for their application in AP processes and to this aim the Langmuir equation has been applied as a simple and straightforward method for estimating the vapor pressure and vaporization enthalpy of various metalorganic precursors. Using benzoic acid as a calibration reference, the vapor pressure-temperature curves for several alk.-earth β-diketonate fluorinated compounds, with mol. formula “M(hfa)₂·L” (with M = Mg, Ca, Sr, Ba; Hhfa = 1,1,1,5,5,5-hexafluoroacetylacetone and L = diglyme, triglyme, and tetraglyme) are derived from their termogravimetric curves. Thus, the enthalpy of vaporization of all complexes has been estimated using the Clausius-Clapeyron equation. As a proof of concept, preliminary results on the use of [Mg(hfa)₂·2H₂O]·2diglyme and [Ca(hfa)₂·diglyme·H₂O] or [Ca(hfa)₂·triglyme] as precursors for AP-MOCVD deposition of MgF₂ and CaF₂ in the form of thin films are presented. This approach may be used to easily determine vapor pressures of complexes and thus evaluate “a priori” the suitability of a compound as precursor for AP-MOCVD and/or spatial ALD. In the experiment, the researchers used many compounds, for example, 2,5,8,11-Tetraoxadodecane (cas: 112-49-2Formula: C8H18O4).

2,5,8,11-Tetraoxadodecane (cas: 112-49-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Formula: C8H18O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, synthesis, and biological evaluation of novel diphenylamine derivatives as tubulin polymerization inhibitors targeting the colchicine binding site was written by Yan, Xiang-Yu;Leng, Jia-Fu;Chen, Ting-Ting;Zhao, Yong-Jun;Kong, Ling-Yi;Yin, Yong. And the article was included in European Journal of Medicinal Chemistry in 2022.Safety of 4-Bromo-2,6-difluoroanisole This article mentions the following:

A novel series of diphenylamine derivatives were designed and synthesized I and their biol. activities were evaluated. The anti-proliferative activities of the derivatives were tested against five human cancer cell lines (MCF-7, MDA-MB-231, A549, HeLa and HT29). Among them, I exhibited the promising anti-proliferative activity against HT29 cell lines with the IC₅₀ value of 23 nM. Further biol. studies depicted that I inhibited cancer cell migration, colony formation and angiogenesis. Besides, dynamics studies and mol. docking studies revealed that I inhibited tubulin polymerization which may be a result of the compound binding to the colchicine site of tubulin. Furthermore,I arrested HT29 cell cycle at G2/M phase, and induced HT29 cell apoptosis by upregulating cyclin B1, Bcl-2, Bax, Cleaved-caspase9, Cleaved-caspase3, PARP, Cleaved-PARP proteins, and downregulating p-cdc25c (S216), p-cdc2 (T15) proteins. Mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) were also determined to confirm the cell apoptosis process. Finally, I greatly inhibited the tumor growth in HT29 xenograft mice by 75.5% at 10 mg/kg. Meanwhile, I owned the good pharmacokinetic properties. All the results promised that I is of potential to act as an antitumor candidate and worthy of further investigation. In the experiment, the researchers used many compounds, for example, 4-Bromo-2,6-difluoroanisole (cas: 104197-14-0Safety of 4-Bromo-2,6-difluoroanisole).

4-Bromo-2,6-difluoroanisole (cas: 104197-14-0) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Safety of 4-Bromo-2,6-difluoroanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Developing Eco-Friendly Skin Care Formulations with Microemulsions of Essential Oil was written by Lee, Sie Huey;Chow, Pui Shan;Yagnik, Chetan Kantilal. And the article was included in Cosmetics in 2022.Safety of 2-(2-Methoxyethoxy)ethanol This article mentions the following:

With the rising public awareness of environmental issues, consumers are increasingly demanding skin care products that create less environmental impact but still provide the same or even greater efficacy. In the skin care arena, microemulsions have been receiving increased attention as the promising delivery technol. of skin care actives. Essential oils such as peppermint oil, lavender oil and eucalyptus oil are purported to have excellent antioxidant and antimicrobial properties that could be used as the eco-friendly alternatives for synthetic antioxidants and preservatives in the skin care formulations. This work therefore seeks to develop eco-friendly skin care formulations based on microemulsions of essential oil. Peppermint oil, lavender oil and eucalyptus oil were used as the oil phase to formulate naringin-loaded microemulsions, which demonstrated similar or better antioxidant and antimicrobial properties compared to the synthetic ones. When formulated into gel form, naringin-loaded microemulsion-gel formulations showed enhanced stability and release profile over their unformulated counterpart. Hence, microemulsions of essential oil developed in this work conferred a 4-fold benefits to the skin care formulations: (1) improved release (membrane permeation) of skin care active, (2) improved stability of skin care active, (3) as an eco-friendly alternative to synthetic antioxidant, and (4) a self-preserving system. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Safety of 2-(2-Methoxyethoxy)ethanol).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Safety of 2-(2-Methoxyethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Extractive distillation of benzene, toluene, and xylenes from pyrolysis gasoline using methylsulfonylethane as a cosolvent was written by Gao, Siliang;Tang, Wencheng;Zhao, Ming;Qie, Siyuan;Pang, Weiwei;Tian, Longsheng. And the article was included in Asia-Pacific Journal of Chemical Engineering in 2021.Synthetic Route of C5H12O3 This article mentions the following:

Highly efficient separation of benzene, toluene, and xylenes (BTXs) from pyrolysis gasoline is very important in petrochem. industries. Though the extractive distillation (ED) process is simpler and consumes less energy compared with liquid-liquid extraction process, it is difficult for a single solvent, for example, sulfolane, to achieve both high purity and high yield of BTXs. In this work, methylsulfonylethane (MSE) was chosen as a cosolvent to improve the selectivity of sulfolane after solvent screening, and factors that may affect the selectivity of the composite solvent were fully investigated, such as the content of cosolvent, solvent to feed ratio, the composition of the feed, and temperature Furthermore, 240 h of continuous extractive distillation and solvent recovery experiment was carried out using sulfolane (85 wt%)-MES (15 wt%) mixture as solvent. The purity of mixed aromatics obtained was 99.83%, and the yield was as high as 99.7%. In the experiment, the researchers used many compounds, for example, 2-(2-Methoxyethoxy)ethanol (cas: 111-77-3Synthetic Route of C5H12O3).

2-(2-Methoxyethoxy)ethanol (cas: 111-77-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Synthetic Route of C5H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem