Tag: 100-200

Analysis of chemosensory markers in cigarette smoke from different tobacco varieties by GC×GC-TOFMS and chemometrics was written by Schwanz, Thiago G.;Bokowski, Liane V. V.;Marcelo, Marcelo C. A.;Jandrey, Angela C.;Dias, Jailson C.;Maximiano, Daniel H.;Canova, Luciana S.;Pontes, Oscar F. S.;Sabin, Guilherme P.;Kaiser, Samuel. And the article was included in Talanta in 2019.Computed Properties of C9H12O3 The following contents are mentioned in the article:

Com. cigarettes are made from a blend of different tobacco varieties, which in turn are the results of different agronomic practices and post-harvest curing processes. The highly complex mixture of smoke compounds reflects each tobacco variety and the levels of sensory-relevant markers. Therefore, the aim of this work was to identify potential relevant chemosensory markers in the mainstream smoke of four main types of com. tobaccos and establish any possible relationship between them and the tobacco growing/curing practices. The tobacco samples were segregated into four segments: (1) three curing stages of flue-cured Virginia, (2) three curing stages of air-cured Burley, (3) three geo-regions of sun-cured Oriental and (4) three different process applied to tobacco. One hundred and twenty cigarettes (10 batches per flavor category) were produced and smoked under standard machine-smoking protocols. The mainstream smoke samples collected were extracted and analyzed by GC × GC TOFMS. The processed data was analyzed by partial least square discriminant anal. (PLS-DA) and the selectivity ratio was used to identify key chemosensory markers responsible for the four segments. All models had sensitivity and specificity equal to unity. Flue-cured Virginia (193 markers) and air-cured Burley (184 markers) showed a similar trend for O-heterocycles markers in the lighter leaf colors and N-heterocycles in the darker leaf colors post-processing, but they had compounds of different flavor descriptions, e. g. sweet and nutty. The three geo-regions of sun-cured Oriental (290 markers) also presented O-heterocycles markers in correlation with leaf sugar contents in addition of sucrose esters markers. The three unusually processed tobacco generated many chem. markers (436 markers), some derived from the so-called Cavendish fermentation process with sweet, spicy and peppery notes, whereas the dark fermented air-cured tobacco presented similar descriptors as air-cured Burley. In addition, some polycyclic aromatic hydrocarbons (PAH) were detected as markers from the fire-curing process. The PLS-DA with selectivity ratio evidenced total of 1098 chemosensory markers in cigarette smoke, in which 173 were tentatively identified. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Computed Properties of C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Computed Properties of C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effects of Radix scrophulariae on hyperthyroidism assessed by metabonomics and network pharmacology was written by Zhang, Ning;Lu, Fang;Li, Zihui;Zhao, Hongwei;Pang, Mu;Ye, Tao;Wang, Xijun;Liu, Shumin. And the article was included in Frontiers in Pharmacology in 2021.Recommanded Product: 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Radix Scrophulariae (Chinese name: Xuanshen), a traditional Chinese herb, is used for the treatment of hyperthyroidism, and in this study, its mechanisms were evaluated by metabonomics and system pharmacol. To study the anti-hyperthyroidism effects of R. Scrophulariae, a male SD rat (180-220 g) model of hyperthyroidism induced by Euthyrox was used. Thirty rats were randomly distributed into three groups: the Model group, the R. Scrophulariae treatment group (RS group) and the healthy Control group. Using the UHPLC/Q-TOF-MS metabolomics approach, 44 metabolites were found to be profoundly altered in the model group, and the levels of these biomarkers were significantly decreased after treatment with R. Scrophulariae. Forty-four metabolites and 13 signaling pathways related to R. Scrophulariae, including the biosynthesis of unsaturated fatty acids, primary bile acid biosynthesis and sphingolipid metabolism, were explored, and linoleic acid metabolism and sphingolipid metabolism were identified as the most relevant metabolic pathways. In addition, the system pharmacol. paradigm revealed that R. Scrophulariae contains 83 active ingredients and is related to 795 genes, and 804 disease genes are related to hyperthyroidism. The construction of the R. Scrophulariaceae-chem. composition-target-hyperthyroidism network identified a total of 112 intersection genes. The enriched gene targets were analyzed, and five pathways were found to be enriched. Among them pathways, the HIF signaling pathway had the highest enrichment score, which indicated that this pathway might be the main signaling pathway related to the treatment of hyperthyroidism by R. Scrophulariae. The integrated approach involving metabolomics and network pharmacol. revealed that R. Scrophulariae might play a role in the treatment of hyperthyroidism by regulating the “IL6-APOA1-cholesterol” pathway and disturbing the HIF signaling pathway. The results demonstrate that the combination of metabolomics and network pharmacol. could be used to reflect the effects of R. Scrophulariae on the biol. network and metabolic state of hyperthyroidism and to evaluate the drug efficacy of R. Scrophulariaceae and its related mechanisms. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Recommanded Product: 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 4-Hydroxy-3-methoxyphenethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors was written by Yin, Yan;Lin, Li;Ruiz, Claudia;Khan, Susan;Cameron, Michael D.;Grant, Wayne;Pocas, Jennifer;Eid, Nibal;Park, HaJeung;Schroter, Thomas;LoGrasso, Philip V.;Feng, Yangbo. And the article was included in Journal of Medicinal Chemistry in 2013.COA of Formula: C10H15NO The following contents are mentioned in the article:

(Benzylureido)arylpyrazoles such as I [R = Me, Et, cyclopropyl, Me₂CH, HOCH₂CH₂, MeOCH₂CH₂, H₂NCH₂CH₂, Me₂NCH₂CH₂, 2-(1-pyrrolidinyl)ethyl, 3-(1-pyrrolidinyl)propyl, 2-(4-morpholinyl)ethyl, 3-(4-morpholinyl)propyl, 2-(1-piperidinyl)ethyl, 3-(1-piperidinyl)propyl; R¹ = H, MeO] were prepared to determine the relationship of structure to their inhibition of rho-associated coiled-coil protein kinase II (α) (ROCK-II). The selectivities of (benzylureido)arylpyrazoles for ROCK-II over protein kinase A, their functional activity in vitro, and their stabilities in human liver microsomes were determined The selectivities of selected (benzylureido)arylpyrazoles such as I [R = Me, HOCH₂CH₂, Me₂NCH₂CH₂, 2-(1-pyrrolidinyl)ethyl, 2-(4-morpholinyl)ethyl, 2-(1-piperidinyl)ethyl; R¹ = H, MeO] for ROCK-II over ROCK-I, JNK, and p38α, their inhibition of cytochrome P₄₅₀ isoforms 1A2, 2C9, 2D6, and 3A4, and their i.v. pharmacokinetics (clearance, volume of distribution, half-life, AUC, maximal concentration in plasma, and bioavailablity) at doses of 1 and 2 mg/kg were determined; the structures of selected compounds bound to ROCK-II were also determined by mol. docking calculations Benzylureidoarylpyrazoles lacking tertiary amino groups such as I (R = Me, HOCH₂CH₂; R¹ = H, MeO) had good pharmacokinetic properties in rats, while those possessing tertiary amino groups such as I [R = 2-(1-pyrrolidinyl)ethyl, 2-(4-morpholinyl)ethyl, 2-(1-piperidinyl)ethyl; R¹ = MeO] had poor pharmacokinetic properties in rats but good aqueous solubilities. (α-Substituted benzyl)ureidoarylpyrazoles were potent ROCK-II inhibitors with high selectivities for ROCK-II over protein kinase A and better microsomal stabilities than (benzylureido)arylpyrazoles substituted at either the urea nitrogen atoms or the central aryl ring and are potentially optimizable as ROCK-II inhibitors. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3COA of Formula: C10H15NO).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C10H15NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of simultaneous use of microwave and ultrasound irradiation on the sulfuric acid hydrolysis lignin depolymerization was written by Rana, Masud;Nshizirungu, Theoneste;Park, Jeong-Hun. And the article was included in Sustainable Energy & Fuels in 2022.COA of Formula: C9H12O3 The following contents are mentioned in the article:

In this study, the individual and combined effects of microwave (MW) and ultrasound (US) processes on the depolymerization of sulfuric acid hydrolysis lignin (SAHL) were investigated in a hybrid microwave-ultrasound chem. reactor. Results revealed that the combined use of MW and US processes led to better results in terms of high yields of bio-oil and monomer production (43.01 and 6.69 wt%), as compared to the individual use of MW (32.83 and 4.71 wt%) and US (21.60 and 3.58 wt%) processes. The highest yield of bio-oil (63.50 wt%), which contained 13.04 wt% monomers, was achieved under the optimized reaction conditions of 180°C, 80 min, 30% US frequency and a 1,4-dioxane to formic acid ratio of 250 : 50 (volume/volume). Process parameters such as temperature, time and the content of formic acid added to 1,4-dioxane were chosen carefully and optimized using response surface methodol. (RSM). The results of the statistical anal. of variance (ANOVA) showed that the depolymerization temperature and time significantly affected (ρ < 0.05) the yield of bio-oil. In the liquid products, the compounds guaiacol (G1), ethanone, 1-(4-hydroxy-3-methoxyphenyl)-(G3), 2-(4-hydroxy-3-methoxyphenyl)acetaldehyde (G10), 4-Et phenol (H1), 4-Me phenol (H4), and di-Bu phthalate (DBPH) were produced as major monomers. Meanwhile, the GPC results showed that the mol. weight of SAHL (Mw = ∼2156) was significantly reduced to lower mol. weight compounds (Mw = 638). The findings obtained from this study suggest that the applied MW-US-assisted lignin depolymerization process could be a promising alternative to the sep. use of the MW or US process and can pave the way to continue advancing the lignin conversion practices as a renewable and sustainable resource of aromatic chems. Moreover, the proposed method is believed to possess great potential for conversion of a major waste stream from a pulp industry into aromatic chem. production Future work will be directed toward the simultaneous use of MW-US-assisted depolymerization of lignin in a continuous flow process mimicking the optimized conditions obtained under batch MW-US conditions. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1COA of Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nonionic Water-Soluble Polysilynes. Synthesis and Properties of a Novel Class of Functionalized Materials was written by Cleij, Thomas J.;Tsang, Stellar K. Y.;Jenneskens, Leonardus W.. And the article was included in Macromolecules in 1999.Name: 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

The nonionic water-soluble polysilynes poly(4,7,10-trioxaundecylsilyne) (I) and poly(4,7,10,13-tetraoxatetradecylsilyne) (II), which are inaccessible using the conventional Wurtz-type coupling with Na in refluxing toluene, were prepared in reasonable yields using graphite potassium C₈K as the reducing agent in THF at 0 °C. A water-insoluble analog of I, viz. poly(4,7,10-trioxahexadecylsilyne) (III), is obtained in nearly quant. yield under similar conditions. Despite the fact that I and II possess all the characteristic polysilylene-like (photo)phys. properties, aqueous solutions of I and II unexpectedly exhibit thermoresponsive behavior; i.e., at 49 °C a lower critical solution temperature (LCST) is found. The presence of an LCST, which has to originate from folding/unfolding processes of the polysilylene backbone, suggests that polysilynes have a hybrid structure with a predominantly one-dimensional overall appearance consisting of linear fragments with small branches and/or incorporated (branched) cyclics, instead of the previously proposed extended sheetlike and/or hyperbranched/dendritic structures. Addnl. support for a hybrid structure was given by semiempirical PM3 calculations on a variety of oligomeric model compounds The PM3 results suggest that Si-Cl moieties incorporated in oligomers will be more reactive than monomeric Si-Cl groups. The calculations further indicate that linear chain extension is preferred over branching. Cyclic voltammetry in combination with absorption/excitation spectroscopy reveals that in going from the related polysilane to the polysilylene the valence band edge shifts ca. -0.7 V, while the conduction band edge remains virtually unchanged. Furthermore, it is demonstrated that polysilynes I and II are effective photoinitiators for radical polymerizations upon excitation at λ 400 nm. This is exemplified for the conversion of Me acrylate into poly(Me acrylate). This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Name: 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Name: 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evaluation of analyte protectants to improve gas chromatographic analysis of pesticides was written by Anastassiades, Michelangelo;Mastovska, Katerina;Lehotay, Steven J.. And the article was included in Journal of Chromatography A in 2003.Reference of 112-59-4 The following contents are mentioned in the article:

A common problem in gas chromatog. (GC) applications is the analyte losses and/or peak tailing due to undesired interactions with active sites in the inlet and column. Analytes that give poor peak shapes or degrade have higher detection limits, are more difficult to identify and integrate, and are more prone to interferences than stable analytes that give narrow peaks. For susceptible analytes, significant peak quality improvements are obtained when matrix components are present because they fill active sites, thus reducing analyte interactions. This phenomenon is called “matrix-induced chromatog. response enhancement”. Several approaches have been proposed to minimize peak distortion phenomena and compensate for matrix-induced effects, which is especially important for accurate quantitation, but each approach has serious limitations for routine multi-pesticide anal. In this study, we demonstrate the feasibility of using “analyte protectants” to provide a more convenient and effective solution to the problem than other approaches developed thus far. The protecting agents are added to extracts and matrix-free standards alike to provide the chromatog. enhancement effect even for the most susceptible analytes in a very dirty GC system. We evaluated 93 compounds to find the most suitable ones for improving chromatog. quality of the signal. Because hydrogen bonding has been shown to be an important factor in analyte interactions with active sites, we mainly focused on additives with strong hydrogen bonding capabilities. Dramatic peak enhancements were achieved using compounds containing multiple hydroxy groups, such as sugars and sugar derivatives, and gulonolactone appears to be the most effective protecting agent for the most pesticides that we tested. The benefits of using analyte protectants vs. alternative procedures for overcoming matrix-induced effects in quantitation include: (a) simpler procedure; (b) easier integration of peaks; (c) lower detection limits; (d) better quantitation; (e) less maintenance of the GC inlet; and (e) lower cost. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Reference of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Reference of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Diethylaminoalkylamino derivatives of carbocyclic series was written by Wojahn, Hans;Erdelmeier, Karl. And the article was included in Archiv der Pharmazie und Berichte der Deutschen Pharmazeutischen Gesellschaft in 1942.Synthetic Route of C10H15NO The following contents are mentioned in the article:

Et₂NCH₂Ac (7 g.) and 5.5 g. m-H₂NC₆H₄OH (I) in 10 cc. EtOH, heated on the water bath for 10 min. and the solution catalytically reduced, give 3 g. of m-hydroxy-[N-(2-diethylamino-1-methylethyl)amino]benzene (II), b₁₆ 185-90°; di-HCl salt, m. 193-4°. I (5.5 g.) and 7.5 g. Et₂N(CH₂)₃Cl, refluxed in 50 cc. C₆H₆ for 12 h., give 6 g. of the N-(3-diethylaminopropyl) isomer of II, b₁₆ 185°; dipicrolonate, m. 214-15°. Et₂NCH₂CMe₂CHO gives the N-(3-diethylamino-2,2-dimethylpropyl) homolog, b₁₄ 180-5°; dipicrolonate, m. 234° (decomposition). 5-Diethylamino-2-pentanone (5.5 g.) and 3.5 g. of I yield 2 g. of the N-[4-diethylamino-1-methylbutyl] homolog of II, b₁₆ 175-8°; dipicrolonate, m. 226°. o-HOC₆H₄CHO and Et₂NCH₂CH₂NH₂, heated 10 min. on the water bath and the Schiff base catalytically reduced, give a poor yield of o-hydroxy-N-(2-diethylaminoethyl)benzylamine (III), b₁₅ 181°; dipicrate, m. 196-7° (decomposition); dipicrolonate, m. 211-12°; the m-HO isomer of III, b₁₄ 184-6°; dipicrolonate, m. 197-9°; the p-HO isomer, b₁₃ 180-2°; dipicrolonate, m. 209°; N-(3-diethylaminopropyl) homolog (IV) of III, b₁₄ 184-7° (3-g. yield from 3.5 g. of o-HOC₆H₄CHO); the m-HO isomer of IV, b₁₆ 200-3°; dipicrolonate, m. 213-15°. o-MeOC₆H₄CH₂NH₂ (5.5 g.) and 5.4 g. of Et₂NCH₂CH₂Cl in 20 cc. EtOH containing 5.5 g. AcONa, refluxed 8 h., give 5 g. of o-methoxy-N-(2-diethylaminoethyl)benzylamine (V), b₁₄ 204-6°; dipicrolonate, yellow, m. 205-7°; p-MeO isomer, b₁₈ 203-5°; dipicrate, m. 140-1°. o-EtO homolog of V, b₁₄ 205-7°; dipicrate, m. 154°. o-MeOC₆H₄CHO and Et₂N(CH₂)₃NH₂ give o-methoxy-N-(3-diethylaminopropyl)benzylamine (VI), b₁₆ 177°; dipicrolonate, m. 212-14°; m-MeO isomer, b₁₃ 191°; dipicrolonate, m. 210-11°; p-MeO isomer, b₁₆ 170°; dipicrolonate, m. 206°; o-EtO homolog of VI, b₁₄ 177°; dipicrolonate, m. 212-14°. o-Methoxy-N-(3-diethylamino-2,2-dimethylpropyl)benzylamine (VII), b₁₄ 186°; dipicrolonate, m. 208-10°; m-MeO isomer, b₁₃ 186°; dipicrolonate, m. 204°; p-MeO isomer, b₁₄ 205°; dipicrolonate, m. 217°. o-EtO homolog of VII, b₁₄ 203-4°; dipicrolonate, m. 202°. o-Methoxy-N-(4-diethylamino-1-methylbutyl)benzylamine, b₁₄ 190-4°; dipicrolonate, m. 149°; m-MeO isomer, b₁₅ 207-13°; dipicrolonate, m. 149°; p-MeO isomer, b₁₄ 203-8°; dipicrolonate, m. 204°. o-MeOC₆H₄CHO, 15 g. MeNH₂.HCl, 15 g. HCO₂Na and 20 g. anhydrous HCO₂H, heated at 150° for 3-4 h., give 13 g. of the formyl derivative, b₁₄ 180-5°; refluxing with 20% HCl for 4 h. gives 8 g. of N-methyl-o-methoxybenzylamine (VIII), b. 226°; picrolonate, m. 176°; p-MeO isomer, b. 238°; formyl derivative, b. 317°. N-Ethyl-o-methoxybenzylamine (IX), b. 238°; formyl derivative, b₁₄ 185-90°; picrolonate, m. 186-80°; m-MeO isomer, b. 245°; formyl derivative, b₁₄ 185-90°; picrolonate, m. 190°; p-MeO isomer, b. 244°; formyl derivative, b₁₄ 187-90°; picrolonate, m. 210°. VIII (3.1 g.), heated with 2.8 g. Et₂NCH₂CH₂Cl and 2.8 g. AcONa in 20 cc. AcOH for 8 h. on the water bath, gives 50% of N-methyl-N-(2-diethylaminoethyl)-o-methoxybenzylamine (X), b₁₄ 170-5°; dipicrolonate, m. 166°; p-MeO isomer, b₁₄ 172-7°; dipicrolonate, m. 195°. N-Et homolog of X, prepared from IX, b₁₄ 185-90°; dipicrolonate, m. 187°; m-MeO isomer, b₁₆ 180-5°; dipicrolonate, m. 200°; p-MeO isomer, b₁₄ 175-80°; dipicrolonate, m. 195°. VIII and Et₂N(CH₂)₃Cl give N-methyl-N-(3-diethylaminopropyl)-o-methoxybenzylamine (XI), b₁₆ 175-80°; dipicrolonate, m. 177°; p-MeO isomer, b₁₄ 195-200°; dipicrolonate, m. 190°. IX gives the N-Et homolog of XI, b₁₄ 187-9°; dipicrolonate, m. 170°; p-MeO isomer, b₁₄ 185-90°; dipicrolonate, m. 210°. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Synthetic Route of C10H15NO).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C10H15NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Improved performance and reduced emissions in a direct injection diesel engine by fuel additives was written by Sharavanan, Ar.;Jaishanker, D.;Saravanan, C. G.. And the article was included in Society of Automotive Engineers in 2001.Related Products of 112-59-4 The following contents are mentioned in the article:

Diesel engineers are major sources of prime movers, which are widely used for small and large-scale power generation and transportation purposes. These engines are widely used owing to its high power output and general thermal efficiency. In spite of these benefits diesel engines cause serious environmental and human discomforts on global scale. The important pollutants from a diesel engine are NO_x HC and particulate matter. These particulates are inhalable, capable of traveling deep into lungs and causes diseases. As a result of this governments and health organizations have tightened the standards for pollutants from diesel engine. Hence it has becomes important that these particulate matter have to be reduced or eliminated from the exhaust f diesel engine. This project aims to reduce the particulate emission in the diesel engine exhaust and to improve the performance of the engine. A literature survey was conducted revealed that using fuel additives, which oxygenate the fuel and reduces the emissions, can reduce the particulate emission. Additives like Ethylene glycol di-Me ether, Diethylene glycol di-Me ether, Diethylene glycol di-Et ether, Bu ether, Aliphatic alc., Aromatic alc. and Glycol ethers were used by various researchers in this field, as fuel additives. Encouraging results were obtained and some of them are reported in this project. In this oxygenates, ethers behave better than alc.’s. Hence for this present work some of the ethers were selected which were not much tried and detail were not much known. Three additives were selected for the fuel. Diethylene glycol mono Bu ether, Diethylene glycol di-Bu ether, and Diethylene glycol mono-n-hexyl ether ether are the additives selected. A single cylinder direct injection diesel engine (Greaves cotton engine) was selected for conducting the tests. These oxygenates were added in different quantities to the selected base fuel, diesel. Load tests and speed tests were conducted first with the sole fuel (diesel) and then with the smoke emissions were deduced to a very great extent, the maximum reduction was obtained while using 4ml of Diethylene glycol mono-n-hexyl ether. The smoke level is reduced from 70HSU to 29HSU, the particulate matter is reduced from 2.801 g/h to 1.512 g/h and the smoke conversion efficiency is found out as 58.57% at full load. A slight decrease in fuel consumption and about 1 to 2% increase in brake thermal efficiency was found out from the experiment conducted, for various loads and speeds which shows obviously an improvement in the performance. The other two additives also shows the same trend except that these values slightly differ indicating that Di-Bu ether comes as second good additive and Diethylene glycol mono Bu ether as third good additive. Detailed results are reported in the results and discussions chapter and conclusions at the end. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Related Products of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evaluation of cytotoxicity and genotoxicity effects of refractory pollutants of untreated and biomethanated distillery effluent using Allium cepa was written by Kumar, Vineet;Ameen, Fuad;Islam, M. Amirul;Agrawal, Sakshi;Motghare, Ankit;Dey, Abhijit;Shah, Maulin P.;Americo-Pinheiro, Juliana Heloisa Pine;Singh, Simranjeet;Ramamurthy, Praveen C.. And the article was included in Environmental Pollution (Oxford, United Kingdom) in 2022.Reference of 112-59-4 The following contents are mentioned in the article:

Environmental pollution caused by the discharge of raw and partly treated distillery effluent has become a serious and threatening problem due to its high pollution load. The aim of the present study was to assess the physicochem. load in alc. distillery effluent before and after biomethanation treatment and the cyto- and genotoxicity effects of refractory pollutants emanated in raw/untreated and biomethanated distillery effluent on the ultrastructural and biochem. responses of Allium cepa root tip cells. Physicochem. anal. revealed high BOD (BOD: 47840-36651 mg L-1), COD (COD: 93452-84500 mg L-1) and total dissolved solids (TDS: 64251-74652 mg L-1) in raw and biomethanated effluent along with metal(loid)s (Fe: 456.152-346.26; Zn: 1.654-1.465; Cu: 0.648-0.562; Ni: 1.012-0.951, and Pb: 0.264 mg L-1) which were beyond the safe discharge values prescribed by the environmental regulatory agencies. The UV-Visible and Fourier transform IR spectrophotometry analyses confirmed the high levels of organic, inorganic, and mixed contaminants discharged in raw and biomethanated distillery effluents. Furthermore, GC-MS anal. characterised chem. contaminants, such as hexadecanoic acid, butanedioic acid, bis(trimethylsilyl) ester; hexadecane, 2,6,11,15-tetramethyl, stigmasterol, and β-sitosterol trimethylsilyl ether that have been reported as androgenic-mutagenic, and endocrine disrupting chems. by the United States Environmental Protection Agency (U.S. EPA). The cytotoxicity measured by A. cepa showed dose depended inhibition root growth inhibition and simultaneous reduction in mitotic index in tested effluents. The chromosomal aberrations studies resulted in laggard chromosomes, sticky chromosomes, vagrant chromosomes, chromosome loss, c-mitosis, chromosome bridge, abnormal metaphase, and disturbed anaphase as found in a dose-dependent manner. Furthermore, dose-dependent enhancement in the levels of malondialdehyde, hydrogen peroxide, and antioxidative enzymes, such as superoxide dismutase, ascorbate peroxidase, and catalase were found to be higher in raw effluents treated root cells compared to biomethanated distillery effluent. Anal. of ultrastructural changes in root tip cells by TEM anal. revealed dramatic changes in the morphol. of cell organelles and accumulation of metallic elements in and on the surface tissues. The results concluded that the discharged distillery effluents retained certain toxic pollutants which imposed cytotoxic and genotoxic hazards to A. cepa. Thus, for the sake of environmental protection, the raw as well as the disposed biomethanated effluent must be efficiently treated before its dumping into the terrestrial ecosystem. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Reference of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Reference of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Phytochemical profiling, molecular docking, and in vitro anti-hepatocellular carcinoid bioactivity of Suaeda vermiculata extracts was written by Mohammed, Hamdoon A.;Almahmoud, Suliman A.;Arfeen, Minhajul;Srivastava, Ashish;El-Readi, Mahmoud Z.;Ragab, Ehab A.;Shehata, Safia M.;Mohammed, Salman A. A.;Mostafa, Ehab M.;El-khawaga, Hend A.;Khan, Riaz A.. And the article was included in Arabian Journal of Chemistry in 2022.COA of Formula: C9H12O3 The following contents are mentioned in the article:

The ATP-binding cassette is the major class of transporters responsible for the efflux of chemotherapeutic agents from cancer cells, resulting in treatment failures of cancer patients. Suaeda vermiculata Forssk. ex. Gmel. is traditionally known for its liver protective activity. The LC-MS based chem. profilings of the sequentially partitioned sub-extracts obtained from the alc. extract of S. vermiculata using n-hexane, chloroform, Et acetate, and n-butanol as fractionating solvents, identified a total of thirty six compounds These sub-extracts were evaluated for their anti-hepatocarcinoma activity against the sensitive HepG2 and doxorubicin (DOX)-resistant, HepG-2/ADR cell lines. A mixture of doxorubicin and sub-extracts at 20 μg/mL doses were also tested for their anti-hepatocarcinoma activity. The exhibited IC50 values for the chloroform, Et acetate, n-hexane, and n-butanol sub-extracts, and the doxorubicin against HepG2, and HepG-2/ADR cell lines were found at 64.5, 66.8, 81.25, 125, 1.3 μg/mL, and 110.1, 91.82, 138.2, 265.7, 4.77 μg/mL levels, resp. However, the treatment of resistant cells with 20 μg/mL of different sub-extracts in combination with the doxorubicin showed significant improvements in the doxorubicin activity against the resistant cells, and the IC50 values for DOX + chloroform, DOX + Et acetate, DOX + n-hexane, and DOX + n-butanol against resistant cells, were at 1.77, 2.05, 2.66, and 2.71 μg/mL levels, resp. The IC50 values exhibited 2.69x, 2.33x, 1.79x and 1.76x-folds reversal of the sensitivity in the resistant cancer cell lines. The mol. docking studies of the compounds identified in the LC-MS chem. profilings, against three ATP-binding cassette proteins i.e., ABCB1, ABCC1, and ABCG2, showed that flavonoids as the major class of compounds responsible for reversal of the resistant cells sensitivities. The predicted binding affinity for the flavonoids against the above mentioned three ATP-binding cassette proteins′ are in the ranges of ~-8 to -11 kcal/mol. Our results clearly indicate that the presence of flavonoids, as the major class of compounds in the S. vermiculata is responsible for the chemosensitization of the resistant HCC-cell lines. Moreover, the structures, 21 (5-O-Me visamminol), 22 (N-trans-feruloyl tyramine), 27 (atractylenolide-III), and 32 (ginsenoside-Rh2) were also identified among the potential ATP-binding cassette′s modulators during the current study. These observations put the S. vermiculata in perspective with the traditionally claimed liver protective efficacy of the plant. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1COA of Formula: C9H12O3).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.COA of Formula: C9H12O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem