Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase Inhibitors was written by Yin, Yan;Lin, Li;Ruiz, Claudia;Khan, Susan;Cameron, Michael D.;Grant, Wayne;Pocas, Jennifer;Eid, Nibal;Park, HaJeung;Schroter, Thomas;LoGrasso, Philip V.;Feng, Yangbo. And the article was included in Journal of Medicinal Chemistry in 2013.COA of Formula: C10H15NO The following contents are mentioned in the article:
(Benzylureido)arylpyrazoles such as I [R = Me, Et, cyclopropyl, Me2CH, HOCH2CH2, MeOCH2CH2, H2NCH2CH2, Me2NCH2CH2, 2-(1-pyrrolidinyl)ethyl, 3-(1-pyrrolidinyl)propyl, 2-(4-morpholinyl)ethyl, 3-(4-morpholinyl)propyl, 2-(1-piperidinyl)ethyl, 3-(1-piperidinyl)propyl; R1 = H, MeO] were prepared to determine the relationship of structure to their inhibition of rho-associated coiled-coil protein kinase II (α) (ROCK-II). The selectivities of (benzylureido)arylpyrazoles for ROCK-II over protein kinase A, their functional activity in vitro, and their stabilities in human liver microsomes were determined The selectivities of selected (benzylureido)arylpyrazoles such as I [R = Me, HOCH2CH2, Me2NCH2CH2, 2-(1-pyrrolidinyl)ethyl, 2-(4-morpholinyl)ethyl, 2-(1-piperidinyl)ethyl; R1 = H, MeO] for ROCK-II over ROCK-I, JNK, and p38α, their inhibition of cytochrome P450 isoforms 1A2, 2C9, 2D6, and 3A4, and their i.v. pharmacokinetics (clearance, volume of distribution, half-life, AUC, maximal concentration in plasma, and bioavailablity) at doses of 1 and 2 mg/kg were determined; the structures of selected compounds bound to ROCK-II were also determined by mol. docking calculations Benzylureidoarylpyrazoles lacking tertiary amino groups such as I (R = Me, HOCH2CH2; R1 = H, MeO) had good pharmacokinetic properties in rats, while those possessing tertiary amino groups such as I [R = 2-(1-pyrrolidinyl)ethyl, 2-(4-morpholinyl)ethyl, 2-(1-piperidinyl)ethyl; R1 = MeO] had poor pharmacokinetic properties in rats but good aqueous solubilities. (α-Substituted benzyl)ureidoarylpyrazoles were potent ROCK-II inhibitors with high selectivities for ROCK-II over protein kinase A and better microsomal stabilities than (benzylureido)arylpyrazoles substituted at either the urea nitrogen atoms or the central aryl ring and are potentially optimizable as ROCK-II inhibitors. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3COA of Formula: C10H15NO).
N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C10H15NO
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem