Tag: 100-200

In 2019,Nature Catalysis included an article by Geng, Huihui; Chen, Xiaobei; Gui, Jingjing; Zhang, Yueteng; Shen, Zuyuan; Qian, Pengfei; Chen, Junwei; Zhang, Shilei; Wang, Wei. Formula: C8H8O2. The article was titled 《Practical synthesis of C1 deuterated aldehydes enabled by NHC catalysis》. The information in the text is summarized as follows:

N-heterocyclic carbenes promoted a reversible hydrogen-deuterium exchange reaction with simple aldehydes, which led to a practical approach to synthetically valuable C1 deuterated aldehydes RC(O)D [R = Ph, Bn, CH=CHPh, etc.]. The reactivity of the well-established N-heterocyclic carbene-catalyzed formation of Breslow intermediates from aldehydes was reengineered to overcome the overwhelmingly kinetically favorable benzoin condensation reaction and achieve the critical reversibility to drive the formation of desired deuterated products when an excess of D2O was employed. Notably, this operationally simple and cost-effective protocol served as a general and truly practical approach to all types of 1-D-aldehydes including aryl, alkyl and alkenyl aldehydes and enabled chemoselective late-stage deuterium incorporation into complex, native therapeutic agents and natural products with uniformly high levels (>95%) of deuterium incorporation for a total of 104 tested substrates. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxybenzaldehyde(cas: 135-02-4Formula: C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Formula: C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Polyhedron included an article by Zeynizadeh, Behzad; Rahmani, Soleiman; Ilkhanizadeh, Siamand. Application In Synthesis of 2-Methoxybenzaldehyde. The article was titled 《Strongly proton exchanged montmorillonite K10 (H+-Mont) as a solid acid catalyst for highly efficient and environmental benign synthesis of biscoumarins via tandem Knoevenagel-Michael reaction》. The information in the text is summarized as follows:

In this study, synthesis of micro/meso porous acid-activated montmorillonite K10 (H+-Mont) was carried out by the activation of Na+-montmorillonite with HCl (4 M) at the controlled conditions. The prepared H+-Mont clay was then characterized using FT-IR, SEM, EDX, XRD and BET analyses. SEM and BET surface analyses represented that by the acid-activation, adjacent layers of montmorillonite K10 (Mont K10) were exfoliated to tiny segments leading to raise of surface area and total pore volume in H+-Mont system rather than the alone Mont K10. Catalytic activity of the prepared H+-Mont clay was further studied as a potent solid acid catalyst for synthesis of biscoumarin materials via tandem Knoevenagel-Michael reaction of 4-hydroxycoumarin with aromatic aldehydes. All reactions were carried out in a mixture of H2O-EtOH (1:1) at room temperature to afford the products in high to excellent yields within 25-50 min. After reading the article, we found that the author used 2-Methoxybenzaldehyde(cas: 135-02-4Application In Synthesis of 2-Methoxybenzaldehyde)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Application In Synthesis of 2-Methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Catalysis included an article by Zhu, Jiancheng; Lindsay, Vincent N. G.. Application In Synthesis of 1-Bromo-3-methoxybenzene. The article was titled 《Benzimidazolyl Palladium Complexes as Highly Active and General Bifunctional Catalysts in Sustainable Cross-Coupling Reactions》. The information in the text is summarized as follows:

A mononuclear and three dinuclear benzimidazolylpalladium complexes such as I·2 PF6- were prepared I·2 PF6- was an air- and moisture-stable catalyst for Suzuki, Sonogashira, and Heck coupling reactions using 0.1-1 mol% catalyst. Changes in the tether between the 2-benzimidazolyl moiety and the pyridine moiety altered the rigidity and conformation of the ligand scaffold and significantly changed the catalytic activities of the complexes. The structures of the mononuclear palladium complex and of two dinuclear benzimidazolylpalladium complexes, including I·2 PF6-·3 MeCN, were determined by X-ray crystallog. The experimental part of the paper was very detailed, including the reaction process of 1-Bromo-3-methoxybenzene(cas: 2398-37-0Application In Synthesis of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Application In Synthesis of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Polytriazole bridged with 2,5-diphenyl-1,3,4-oxadiazole moieties: a highly sensitive and selective fluorescence chemosensor for Ag+》 was published in RSC Advances in 2015. These research results belong to Cao, Shoupeng; Pei, Zhichao; Xu, Yongqian; Zhang, Ruina; Pei, Yuxin. Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzene The article mentions the following:

Fluorescent conjugated polytriazoles (FCP 1-4) containing both 2,5-diphenyl-1,3,5-oxadiazole (OXD) and 1,2,3-triazole moieties in the main chain were synthesized from aromatic diazide (1) and dialkynes (2-5) via click polymerization, resp. In the polymers, OXDs (fluorophores) and triazole rings (generated via CuAAC acting as metal ion ligands) comprise a fluorescent system. The polytriazoles displayed relatively strong emission with quantum yields in the range of 0.20-0.28 at room temperature in DMF. The study on their ion-responsive properties showed that, although all four FCPs have good selectivity for Ag+, the integration of alkoxy side groups (methoxy for FCP 2, hexyloxy for FCP 3 and 2-ethylhexyloxy for FCP 4) to the main chains of the polytriazoles decreased their sensitivity for Ag+via alteration of the polymer aggregation status and electron d. of the main chains. Thus FCP 1 is highly sensitive for Ag+, where its Ksv is as high as 1.44 × 105 M-1 and its lowest detection limit is in the ppb range (4.22 × 10-7 M). This study provides an efficient click approach to the synthesis of a novel fluorescence sensor for Ag+ detection, which could expand the application of click polymerization in designing fluorescence sensors based on the triazole unit. In addition to this study using 1,4-Diethynyl-2,5-dimethoxybenzene, there are many other studies that have used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzene) was used in this study.

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzene They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Nickel-Catalyzed Reductive Cross-Coupling of Aryl Bromides with Vinyl Acetate in Dimethyl Isosorbide as a Sustainable Solvent》 was written by Su, Mincong; Huang, Xia; Lei, Chuanhu; Jin, Jian. Electric Literature of C7H7BrOThis research focused onvinyl arene heteroarene benzoheterocycle preparation green chem; aryl heteroaryl bromide vinyl acetate reductive cross coupling; dimethyl isosorbide solvent nickel catalyst. The article conveys some information:

A nickel-catalyzed reductive cross-coupling has been achieved using (hetero)aryl bromides and vinyl acetate as the coupling partners. This mild, applicable method provides a reliable access to a variety of vinyl arenes, heteroarenes, and benzoheterocycles, which should expand the chem. space of precursors to fine chems. and polymers. Importantly, a sustainable solvent, di-Me isosorbide, is used, making this protocol more attractive from the point of view of green chem. In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-methoxybenzene(cas: 2398-37-0Electric Literature of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Electric Literature of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Chemical Science included an article by Zhang, Yitao; Takale, Balaram S.; Gallou, Fabrice; Reilly, John; Lipshutz, Bruce H.. Category: ethers-buliding-blocks. The article was titled 《Sustainable ppm level palladium-catalyzed aminations in nanoreactors under mild, aqueous conditions》. The information in the text is summarized as follows:

A 1 : 1 Pd : ligand complex, [t-BuXPhos(Pd-Π-cinnamyl)]OTf, was identified as a highly robust pre-catalyst for amination reactions leading to diarylamines, where loadings of metal were typically at 1000 ppm Pd, run in water at temperatures between rt and 45 °C. The protocol was exceptionally simple, readily scaled and compared very favorably vs. traditional amination conditions. It was shown to successfully led to key intermediates associated with several physiol. active compounds In the part of experimental materials, we found many familiar compounds, such as 1-Bromo-3-methoxybenzene(cas: 2398-37-0Category: ethers-buliding-blocks)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ChemistrySelect included an article by Mellado, Marco; Salas, Cristian O.; Uriarte, Eugenio; Vina, Dolores; Jara-Gutierrez, Carlos; Matos, Maria J.; Cuellar, Mauricio. Electric Literature of C8H8O2. The article was titled 《Design, Synthesis and Docking Calculations of Prenylated Chalcones as Selective Monoamine Oxidase B Inhibitors with Antioxidant Activity》. The information in the text is summarized as follows:

The synthesis of seven new prenylated chalcones I (R = Ph, 2-HOC6H4, 4-MeOC6H4, etc.) obtained from the natural compound, 4-hydroxy-3-(3-methylbut-2-en-1-yl)acetophenone, previously isolated from S. graveolens, is reported. Five of these compounds exhibited high inhibition and selectivity against MAO-B with IC50 values in the low micromolar range. In addition, the antioxidant activity of this series was measured, with three compounds showing a better activity than the reference, butylated hydroxytoluene (BHT). Compound I (R = 4-Me2NC6H4) proved to be the best compound within the studied series (IC50 MAO-B = 8.19 μM and k DPPH = 3.73). Finally, mol. docking was performed to better understand the binding properties of these derivatives Important features for MAO-B inhibitory activity observed were hydrogen-bonding interaction between Tyr435 and nearness with Tyr398 and FAD co-factor. Therefore, these mols. were good candidates for the design of a lead compound for Parkinson’s disease. In addition to this study using 2-Methoxybenzaldehyde, there are many other studies that have used 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Electric Literature of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic Letters included an article by Tan, Jian-Ping; Yu, Peiyuan; Wu, Jia-Hong; Chen, Yuan; Pan, Jianke; Jiang, Chunhui; Ren, Xiaoyu; Zhang, Hong-Su; Wang, Tianli. Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde. The article was titled 《Bifunctional Phosphonium Salt Directed Enantioselective Formal [4 + 1] Annulation of Hydroxyl-Substituted para-Quinone Methides with α-Halogenated Ketones》. The information in the text is summarized as follows:

A highly diastereo- and enantioselective [4 + 1] cycloaddition of para-quinone methides to α-halogenated ketones was realized by bifunctional phosphonium salt catalysis, furnishing functionalized 2,3-dihydrobenzofurans in high yields and excellent stereoselectivities (>20:1 dr and up to >99.9% ee). Mechanistic observations suggested that the reaction underwent a cascade intermol. substitution/intramol. 1,6-addition process. DFT calculations revealed multiple H-bonding interactions between the catalyst and the enolate intermediate in the stereodetermining transition states. In addition to this study using 2-Hydroxy-4-methoxybenzaldehyde, there are many other studies that have used 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Name: 2-(Benzyloxy)acetaldehydeIn 2021 ,《Asymmetric Synthesis of Homoallylic Alcohols Featuring Vicinal Tetrasubstituted Carbon Centers via Dual Pd/Photoredox Catalysis》 was published in Organic Letters. The article was written by Xue, Sijing; Limburg, Bart; Ghorai, Debasish; Benet-Buchholz, Jordi; Kleij, Arjan W.. The article contains the following contents:

Dual palladium/photoredox-catalysis provides an effective method for the decarboxylative asym. synthesis of vicinal α,β-tri/tetra- or α,β-tetrasubstituted homoallylic alcs. using Hantzsch-type esters as radical precursors. This mild methodol. capitalizes on vinyl cyclic carbonates as accessible reagents providing the target mols. in appreciable to good yields, high branch selectivity, and enantiomeric ratios of up to 94:6, making it a rare example of using prochiral electrophiles for the creation of vicinal congested carbon centers. After reading the article, we found that the author used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Name: 2-(Benzyloxy)acetaldehyde)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Name: 2-(Benzyloxy)acetaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

HPLC of Formula: 150-19-6In 2020 ,《Enantioselective Synthesis of Tertiary α,α-Diaryl Carbonyl Compounds Using Chiral N,N’-Dioxides under Umpolung Conditions》 was published in Organic Letters. The article was written by Um, Tae-Woong; Lee, Girim; Shin, Seunghoon. The article contains the following contents:

Bronsted acid-catalyzed addition of the chiral N,N’-dioxide into ynamides generated enolonium ions in situ which underwent enantioselective alkylation by indoles, pyrroles, and phenols, without racemization of the formed tertiary center. This external oxidant approach allows for the use of unmodified nucleophiles and does not leave trace groups from the oxidant, which significantly increases the synthetic efficiency and the product diversity. Furthermore, the byproduct of the N,N’-dioxide could be efficiently recycled into an optically pure form. The results came from multiple reactions, including the reaction of m-Methoxyphenol(cas: 150-19-6HPLC of Formula: 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.HPLC of Formula: 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem