Tag: 167.205

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20781-20-8 as follows. category: ethers-buliding-blocks

Ethyl bromoacetate (Scheme 28) (10.0 gm, 59.87 mmol) solution in 20.0 mL of anhydrous THF was added dropwise to a solution of (2,4-dimethoxybenzyl)amine (10.0 gm, 59.81 mmol) and tri ethyl amine (6.06 gm, 59.87 mmol) in anhydrous THF (20.0 mL) at 0 C under nitrogen atmosphere. The reaction mixture was warmed to room temperature and stirred overnight. Brine was added – 100 mL, and the reaction mixture was extracted with ethyl acetate (2 x – 100 mL). Combined extracts were dried over anhydrous MgS04 and concentrated under reduced pressure. The purification was performed using combiFlash chromatography, Gradient: 20:80 to 50:50 v/v Ethyl acetate: Hexane. 7.6 gm (yield 50.2 %) of the alkylation product was obtained as a colorless liquid m/z calculated for C13H19NO4 [M+H]+: 254; Obtained: 254.1.

According to the analysis of related databases, 20781-20-8, the application of this compound in the production field has become more and more popular.

Synthetic Route of 1836-62-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Corresponding 2-(aryloxymethyl)oxiranes (5 mmol, 1 equiv) and amines (7.5 mmol, 1.5 equiv) were dissolved in 30 mL i-PrOH. The reaction was purged with argon 3 times and stirred at reflux for 5 h, andthen the mixture was cooled to room temperature and added AcOEt.After washing with brine 3 times, the organic layer was dried overanhydrous Na2SO4, filtered, and evaporated in vacuo. Purification ofthe crude residue by column chromatography on silica gel yielded target compounds.

The synthetic route of 2-(2-Methoxyphenoxy)ethylamine has been constantly updated, and we look forward to future research findings.