In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 20781-20-8 as follows. category: ethers-buliding-blocks
Ethyl bromoacetate (Scheme 28) (10.0 gm, 59.87 mmol) solution in 20.0 mL of anhydrous THF was added dropwise to a solution of (2,4-dimethoxybenzyl)amine (10.0 gm, 59.81 mmol) and tri ethyl amine (6.06 gm, 59.87 mmol) in anhydrous THF (20.0 mL) at 0 C under nitrogen atmosphere. The reaction mixture was warmed to room temperature and stirred overnight. Brine was added – 100 mL, and the reaction mixture was extracted with ethyl acetate (2 x – 100 mL). Combined extracts were dried over anhydrous MgS04 and concentrated under reduced pressure. The purification was performed using combiFlash chromatography, Gradient: 20:80 to 50:50 v/v Ethyl acetate: Hexane. 7.6 gm (yield 50.2 %) of the alkylation product was obtained as a colorless liquid m/z calculated for C13H19NO4 [M+H]+: 254; Obtained: 254.1.
According to the analysis of related databases, 20781-20-8, the application of this compound in the production field has become more and more popular.