Tag: 200-300

On September 1, 2008, Deepa, P.; Jayakannan, M. published an article.Reference of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene The title of the article was Polyurethane-oligo(phenylenevinylene) random copolymers: π-conjugated pores, vesicles, and nanospheres via solvent-induced self-organization. And the article contained the following:

We report a new series of polyurethane-oligo(phenylenevinylene) (OPV) random copolymers and their self-assembled nanomaterials such as pores, vesicles, and luminescent spheres. The polymers were synthesized through melt transurethane process by reacting a hydroxyl-functionalized OPV with diurethane monomer and diol under solvent-free and nonisocyanate conditions. The amount of OPV was varied up to 50 mol % in the feed to incorporate various amounts of π-conjugated segments in the polyurethane backbone. The π-conjugated segmented polymers were subjected to solvent induced self-organization in THF or THF+water to produce variety of morphologies ranging from pores (500 nm to 1 μm) to spheres (100 nm to 2 μm). Upon shining 370-nm light, the dark solid nanospheres of the copolymers transformed into blue luminescent nanoballs under fluorescence microscope. The mechanistic aspects of the self-organization process were studied using solution FTIR and photophys. techniques such as absorption and emission to trace the factors which control the morphol. FTIR studies revealed that the hydrogen bonding plays a significant role in the copolymers with lower amount of OPV units. Time resolved fluorescent decay measurements of copolymers revealed that mol. aggregation via π-conjugated segments play a major role in the samples with higher OPV content in the random block polymers. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Reference of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

The Article related to polyurethane oligophenylenevinylene nanosphere, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Reference of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

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On July 12, 2022, Kleybolte, Moritz E.; Vagin, Sergei I.; Rieger, Bernhard published an article.Application of 146370-51-6 The title of the article was High-Molecular-Weight Bisalkoxy-Substituted Poly(para)phenylenes by Kumada Polymerization. And the article contained the following:

Substituted poly(para)phenylenes (PPPs) are conjugated polymers with an attractive application potential in various fields of materials science. They are synthesized nearly exclusively using catalytic cross-coupling polymerization reactions based on Pd- or Ni-catalysts. Among these synthetic approaches to access alkoxy-substituted PPPs, Kumada catalyst transfer polymerization (KCTP or GRIM polymerization) would offer certain economic advantages over Suzuki-type polymerization as it relies on the utilization of a non-precious metal for catalysis. It also results in less total costs of the utilized reagents, avoiding addnl. preparative steps such as synthesis, isolation, and purification of boronic acid derivatives necessary for the Suzuki reaction. In fact, KCTP is nowadays the state-of-the-art method for the synthesis of polythiophenes. However, the application of KCTP for the synthesis of alkoxy-substituted PPPs leads to polymers with low mol. weights, limiting their practical applicability. Here, we developed a synthesis protocol that resulted in MEH-PPP with a mol. weight of Mn = 133 kg/mol and BHex-PPP with Mn = 153 kg/mol relative to polystyrene, outperforming the previous state of the art by a factor more than 5. Also, a tetra(ethylene glycol)-substituted PPP has been prepared by this procedure, with a mol. weight exceeding the previously reported results for analogous structures. Such mol. weights can be obtained in a reasonable reaction time (5 days) using low concentrations of an N-heterocyclic carbene-coordinated Ni complex. The polymerization kinetics suggested a chain-growth mechanism with a chain transfer step. The latter is caused most likely by a bimol. interaction of the Ni-species at the polymer chain ends. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Application of 146370-51-6

The Article related to bisalkoxy polyphenylene kumada polymerization, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Application of 146370-51-6

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On November 30, 2000, Pan, Jiang-Qing; Chen, Zi-Kuan; Xiao, Yang; Huang, Wei published an article.HPLC of Formula: 146370-51-6 The title of the article was Synthesis and characterization of fully soluble polyphenylenevinylene. And the article contained the following:

Fully soluble poly[2-(2-ethylhexyloxy)-5-methoxy-p-phenylenevinylene] was synthesized by the polymerization of 2-(2-ethylhexyloxy)-5-methoxy-1,4-xylylene dibromide with addition of mol. weight modifiers (chain stopper, free radical scavengers) to a polymerization system containing monomer, catalyst, and solvent. The polymers synthesized in this work were characterized by IR, NMR, and UV-visible spectroscopy, and gel-permeation chromatog. Results show that the weight-average mol. weight of the polymer can be controlled by the addition of chain stopper (benzyl bromide) and radical inhibitor (BHT). The polymerization mechanism in the presence of these additives was also discussed. A dual mechanism involving carbene for the polymerization was proposed. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).HPLC of Formula: 146370-51-6

The Article related to polyphenylenevinylene preparation solubility, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.HPLC of Formula: 146370-51-6

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On July 25, 2009, Ryu, Jung-Yi; Lee, Tae-Hoon; Kim, Tae-Hoon; Koo, Chul-Whoi; Son, Se-Mo published an article.SDS of cas: 146370-51-6 The title of the article was Mobility characteristics of novel oligomer structuralized by biphenyl conjugated with electron donating units. And the article contained the following:

Oligomers containing biphenyl backbone were prepared by using Wittig reaction and their optical properties were characterized. The drift mobility of oligomers was measured by using TOF method. The drift mobility showed elec. field-dependent character and coincidence with Poole-Frankel relation. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).SDS of cas: 146370-51-6

The Article related to electron mobility biphenyl conjugated electron donating unit oligomer, Physical Properties of Synthetic High Polymers: Physical Interactions Of Polymers and other aspects.SDS of cas: 146370-51-6

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On May 18, 2018, Wang, Xu; He, Dandan; Huang, Yubing; Fan, Qihang; Wu, Wanqing; Jiang, Huanfeng published an article.Product Details of 157869-15-3 The title of the article was Copper-Catalyzed Synthesis of Substituted Quinazolines from Benzonitriles and 2-Ethynylanilines via Carbon-Carbon Bond Cleavage Using Molecular Oxygen. And the article contained the following:

A copper-catalyzed process for the synthesis of substituted quinazolines from benzonitriles and 2-ethynylanilines using mol. oxygen (O2) as sole oxidant is described. The mild catalytic system enabled the effective cleavage of the C-C triple bond and construction of new C-N and C-C bonds in one operation. Furthermore, the compound N,N-dimethyl-4-(2-(4-(trifluoromethyl)phenyl)quinazolin-4-yl)aniline (3dj) exhibited obvious aggregation-induced emission phenomenon, and the fluorescence quantum yield (ΦF,film) and lifetime (τfilm) were measured to be 45.5% and 5.8 ns in thin films state, resp. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Product Details of 157869-15-3

The Article related to copper catalyzed cyclization benzonitrile ethynylaniline carbon bond cleavage oxygen, diphenyl quinazoline preparation crystal mol structure, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 157869-15-3

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On January 7, 2010, Marsilje, Thomas H., III; Lu, Wenshuo; Chen, Bei; He, Xiaohui; Lee, Christian Cho-Hua; Jiang, Songchun; Yang, Kunyong published a patent.Synthetic Route of 152626-77-2 The title of the patent was Preparation of substituted 2-(phenylamino)pyrimidin-4-amine as IGF-1 receptor and anaplastic lymphoma kinase inhibitors for treating proliferative disorders. And the patent contained the following:

The invention is related to the preparation of pyrimidine derivatives I [ring E may optionally contain a double bond; one of Z1-3 = NR6, N(R6)(:O) or S(O)1-2 and the others are CR2; R6 = H, azetidin-3-yl, 1,1-dioxo-2H-thiopyran-4-yl,, (un)substituted alk(en/yn)yl, 4-(pyrrolidin-1-yl)-1-oxobutyl, 3-morpholinopropylsulfonyl, etc.; R2 = (un)substituted 2-oxo-1,2-dihydropyridin-3-yl, 2-oxoazepan-3-yl, 5-6 membered heteroaryl containing 1-3 heteroatoms selected from N, O and S; R1 = halo, optionally halogenated alkyl; R3, R4 = H; R5 = halo, OH, alkyl, alkoxy, CN, etc.; X = Y = (CH)0-1; m = 2-4] and their physiol. acceptable salts which may be used to treat, ameliorate or prevent a condition which responds to inhibition of insulin-like growth factor (IGF-1R) or anaplastic lymphoma kinase (ALK), and to their pharmaceutical compositions Thus, monoamination of 2,5-dichloro-N-(5-methyl-1H-pyrazol-3-yl)pyrimidin-4-amine (preparation given) with tert-Bu 4-(4-amino-5-fluoro-2-methylphenyl)piperidine-1-carboxylate (preparation given) and reductive amination of formaldehyde gave II. Selected I had IC50 values in the range of 1 nM – 1 μM for the inhibition of IGF-1R. The experimental process involved the reaction of 4-Bromo-5-methoxy-2-methylaniline(cas: 152626-77-2).Synthetic Route of 152626-77-2

The Article related to phenylaminopyrimidineamine preparation igf1r anaplastic lymphoma kinase inhibitor antiproliferative neoplasm, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 152626-77-2

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On October 1, 2013, Liu, Qing; Zhao, Yufen; Fu, Hua; Cheng, Changmei published an article.Formula: C8H10BrNO The title of the article was Copper-catalyzed sequential N-arylation and aerobic oxidation: synthesis of quinazoline derivatives. And the article contained the following:

A novel and efficient copper-catalyzed cascade method for the synthesis of quinazoline derivatives was developed. The protocol uses readily available substituted (2-bromophenyl)methanamines and amidine hydrochlorides as the starting materials, inexpensive CuBr as the catalyst, and economical and environment friendly air as the oxidant, and the corresponding quinazoline derivatives were obtained in moderate to good yields. The procedure underwent sequential intermol. N-arylation, intramol. nucleophilic substitution and aerobic oxidation The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Formula: C8H10BrNO

The Article related to bromobenzylamine amidine hydrochloride cascade arylation copper catalyst, quinazoline preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C8H10BrNO

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On November 19, 2010, Wang, Chen; Li, Shangfu; Liu, Hongxia; Jiang, Yuyang; Fu, Hua published an article.Category: ethers-buliding-blocks The title of the article was Copper-Catalyzed Synthesis of Quinazoline Derivatives via Ullmann-Type Coupling and Aerobic Oxidation. And the article contained the following:

A simple and efficient copper-catalyzed approach to quinazoline derivatives has been developed, and the protocol uses readily available substituted (2-bromophenyl)methylamines and amides as the starting materials, and the cascade reactions were performed under air via sequential Ullmann-type coupling and aerobic oxidation without addition of any ligand or additive. The present method provides a convenient and practical strategy for synthesis of quinazoline derivatives The experimental process involved the reaction of (2-Bromo-5-methoxyphenyl)methanamine(cas: 887581-09-1).Category: ethers-buliding-blocks

The Article related to quinazoline preparation, ullmann type coupling aerobic oxidation bromophenylmethylamine amide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: ethers-buliding-blocks

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On October 18, 2018, Trzoss, Lynnie; Betancort, Juan Manuel; Kanouni, Toufike; Wallace, Michael Brennan; Boloor, Amogh published a patent.Recommanded Product: 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane The title of the patent was Preparation of N-containing heteroaryl pyridone compounds as selective CREB-binding protein inhibitors for treatment of cancer, immune disorders, and inflammatory diseases. And the patent contained the following:

The present embodiments relate to substituted heterocyclic derivatives of formula I, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Compounds of I [wherein X = N or CR7; R7 = H, halo, alkyl, or alkoxy; R2 = H, alkyl, (hetero)aryl, etc.; R5 = H, halo, CN, (un)substituted aryl, etc.; R6 = H, halo, CN, heteroaryl, etc.; R8 = (un)substituted heteroaryl] or pharmaceutically acceptable salts thereof, are claimed and exemplified. Example compound II was prepared from a multistep procedure (preparation given). Said compositions and methods are useful for the treatment of diseases mediated by aberrant cell signaling, such as inflammatory disorders, cancer and neoplastic disease. Particular compounds described herein exhibit selective inhibitory activity against CREB-binding protein (CBP) compared with BRD4. Exemplified I were evaluated for CBP inhibitory activity with some compounds demonstrating IC50 values of ≥ 0.5 μM (data provided). The experimental process involved the reaction of 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane(cas: 1417036-28-2).Recommanded Product: 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

The Article related to heteroarylpyridone preparation creb binding protein cancer inflammation immune disorder, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 2-(3-Methoxy-4-methylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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On November 29, 2002, Coulon, Estelle; Pinson, Jean; Bourzat, Jean-Dominique; Commercon, Alain; Pulicani, Jean-Pierre published an article.Application of 53136-21-3 The title of the article was Surface-Modified Carbon Felts: Possible Supports for Combinatorial Chemistry. And the article contained the following:

It is possible to prepare carbon-based analogs of the Merrifield resin by electrochem. reduction of diazonium salts or oxidation of aryl acetates on high sp. surface area carbon felts. These modified felts can undergo further reactions: nucleophilic substitution, Suzuki reaction, and finally reductive electrochem. cleavage, taking advantage of the conductivity of the carbon felt. This provides a simple example of the possible use of electrochem. in combinatorial synthesis. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Application of 53136-21-3

The Article related to carbon felt support aryl sulfide electrochem reduction, aryl thiol preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Alcohols and Thiols and other aspects.Application of 53136-21-3

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