Tag: 200-300

《Small organic molecules with tailored structures: initiators in the transition-metal-free C-H arylation of unactivated arenes》 was published in RSC Advances in 2020. These research results belong to Liu, Zhenghui; Wang, Peng; Chen, Yu; Yan, Zhenzhong; Chen, Suqing; Chen, Wenjun; Mu, Tiancheng. Related Products of 529-28-2 The article mentions the following:

In this article, an optimized catalytically active mol., (2-(methylamino)phenyl)methanol, was designed. A broad range of aryl iodides RI (R = 2-fluorophenyl, thiophen-3-yl, pyridin-4-yl, etc.) could be converted into the corresponding arylated products RR1 (R1 = Ph, 4-methylphenyl) at 100°C over 24 h with good to excellent yields. Mechanistic experiments verified that radicals participated in this catalytic transformation and that the cleavage of the aromatic C-H bond was not the rate determining step. A K+ capture experiment by 18-crown-6 emphasized the significance of the cation species of the strong base. Fourier transform IR spectroscopy proved that the catalytic system was activated by the hydrogen bonds between small organic mols. and tBuOK. Also, a clear mechanism was proposed. This transition-metal-free method affords a promising system for efficient and inexpensive synthesis of biaryls via a user-friendly approach, as confirmed by scale-up experiments In the experiment, the researchers used many compounds, for example, 1-Iodo-2-methoxybenzene(cas: 529-28-2Related Products of 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Related Products of 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Omega included an article by Gautam, Prashant; Tiwari, Neelam J.; Bhanage, Bhalchandra M.. Application of 529-28-2. The article was titled 《Aminophosphine Palladium Pincer-Catalyzed Carbonylative Sonogashira and Suzuki-Miyaura Cross-Coupling with High Catalytic Turnovers》. The information in the text is summarized as follows:

In the presence of palladium pincer complex I, aryl iodides underwent carbonylative Sonogashira and Suzuki coupling reactions with aryl alkynes and cyclopropylacetylene and arylboronic acids mediated by K2CO3 in propylene carbonate to yield aryl alkynones and diaryl ketones, resp. Using I, the carbonylative Sonogashira and Suzuki coupling reactions were carried out at 10-4 mol% and 10-6 mol%, resp. Palladium nanoparticles generated from I were characterized. The results came from multiple reactions, including the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Application of 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Application of 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic Letters included an article by Lv, Weiwei; Chen, Yanhui; Zhao, Zemin; Wen, Si; Cheng, Guolin. Reference of 1-Iodo-2-methoxybenzene. The article was titled 《Palladium-Catalyzed Regioselective Heck Coupling of Alkynes with Aryl Iodides for the Synthesis of Trisubstituted Allenes》. The information in the text is summarized as follows:

A utility approach toward trisubstituted allenes through Pd-catalyzed alkynyl Heck coupling reaction of alkynes and aryl iodides is reported. This process proceeded via regioselective carbopalladation of 1-aryl-1-alkynes to give alkenyl palladium species, which undergo β-hydride elimination to provide 1,1-diarylallenes in 25-71% yields. This method features unique regioselectivity and high functional group compatibility. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Reference of 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Reference of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Catalysis included an article by Hamasaka, Go; Roy, David; Tazawa, Aya; Uozumi, Yasuhiro. Recommanded Product: 1-Iodo-2-methoxybenzene. The article was titled 《Arylation of Terminal Alkynes by Aryl Iodides Catalyzed by a Parts-per-Million Loading of Palladium Acetate》. The information in the text is summarized as follows:

Arylation of terminal alkynes (16 varieties) by aryl iodides (28 varieties) was achieved with a mol ppm loading level of palladium catalyst, where a variety of functional groups including heteroarenes were tolerated. Thus, the arylations were carried out in the presence of palladium acetate at ppm loadings and potassium carbonate in ethanol at 80° to give the corresponding internal alkynes in good to excellent yields. Synthesis of 2-phenyl-3-(phenylalkynyl)benzofuran was achieved by iterative use of the alkyne arylation under mol ppm catalytic conditions. Reaction-rate anal., transmission electron microscopic ex-amination of the reaction mixture, and mercury-amalgamation test were performed to gain insight into the active species of the highly active ppm catalytic species. Transmission electron microscopic (TEM) examination of the reaction mixture revealed that palladium nanoparticles were generated in situ under the reaction conditions, and their cluster size was variable during the catalytic reaction. A variation in size of palladium particles suggested that the composition-decomposition process of Pd aggregates should take place in situ via monomeric palladium(0) species and/or fine palladium(0) clusters which might be real catalytic species in this reaction. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-2-methoxybenzene(cas: 529-28-2Recommanded Product: 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Recommanded Product: 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 882-33-7In 2021 ,《Rhodium-Catalyzed Twofold Unsymmetrical C-H Alkenylation-Annulation/Thiolation Reaction To Access Thiobenzofurans》 was published in Organic Letters. The article was written by Lin, Jian; Hu, Liuyu; Chen, Chao; Feng, Huijin; Yu, Yang; Yang, Yaxi; Zhou, Bing. The article contains the following contents:

A Rh(III)-catalyzed twofold unsym. C-H alkenylation-annulation/thiolation reaction was developed, enabling the straightforward and efficient synthesis of various thiobenzofurans I [R1 = Me, Et, Ph, CH2CH2OBn; R2 = H, Me; R3 = n-Pr, Ph, 2-thienyl, etc.; R4 = H, OMe, F, OBn; R5 = H, Me, Br, etc.; R4R5 = OCH2O, OCH2CH2O] in one step. This robust protocol proceeded with a broad substrate scope and good functional group tolerance under relatively mild reaction conditions. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Application of 882-33-7) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Application of 882-33-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Catalyst-free visible-light-initiated oxidative coupling of aryldiazo sulfones with thiols leading to unsymmetrical sulfoxides in air》 were Liu, Qishun; Wang, Leilei; Yue, Huilan; Li, Jiang-Sheng; Luo, Zidan; Wei, Wei. And the article was published in Green Chemistry in 2019. COA of Formula: C12H10S2 The author mentioned the following in the article:

A facile and efficient visible-light-driven method was developed to construct sulfoxides via oxidative coupling of aryldiazo sulfones with thiols using the O2 in air as the oxidant. This reaction could be performed at room temperature under catalyst and additive-free conditions. The methodol. offered a mild and environmentally benign approach to obtain a library of sulfoxides in good yields with favorable functional group tolerance. The experimental process involved the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7COA of Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.COA of Formula: C12H10S2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Electrochemical oxidative cyclization of activated alkynes with diselenides or disulfides: access to functionalized coumarins or quinolinones》 were Hua, Jiawei; Fang, Zheng; Xu, Jia; Bian, Mixue; Liu, ChengKou; He, Wei; Zhu, Ning; Yang, Zhao; Guo, Kai. And the article was published in Green Chemistry in 2019. Related Products of 882-33-7 The author mentioned the following in the article:

A direct electrochem. oxidative cyclization of alkynoates and alkynamides with diselenides or disulfides for the synthesis of coumarins and quinolinones bearing a chalcogen functional group was developed. This green and efficient approach was realized through a constant current electrolysis in an undivided cell under metal-free and oxidant-free conditions. Moreover, a series of selenium/sulfur-substituted coumarin and quinolinone products were obtained in moderate to good yields with a broad scope and functional group tolerance. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diphenyldisulfane(cas: 882-33-7Related Products of 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Related Products of 882-33-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ChemPhysChem included an article by Demaison, Jean; Vogt, Natalja; Saragi, Rizalina Tama; Juanes, Marcos; Rudolph, Heinz Dieter; Lesarri, Alberto. Quality Control of 1,2-Diphenyldisulfane. The article was titled 《The S-S Bridge: A Mixed Experimental-Computational Estimation of the Equilibrium Structure of Diphenyl Disulfide》. The information in the text is summarized as follows:

The disulfide bridge (-S-S-) is an important structural motif in organic and protein chem., but only a few accurate equilibrium structures are documented. We report the results of supersonic-jet microwave spectroscopy experiments on the rotational spectra of di-Ph disulfide, C6H5-S-S-C6H5 (including all 13C and 34S monosubstituted isotopologues), and the determination of the equilibrium structure by the mixed estimation (ME) method. A single conformation of C2 symmetry was observed in the gas phase. This disulfide is a challenging target since its structure is determined by 34 independent parameters. Addnl., ab initio calculations revealed the presence of three low-frequency vibrations (<50 cm-1) associated to Ph torsions which would prevent the calculation of an accurate force field. For this reason, instead of the semiexperimental method, we used the mass-dependent (rm) method to fit the structural parameters concurrently to moments of inertia and predicate parameters, affected with appropriate uncertainties. The predicates were obtained by high-level quantum-chem. computations. A careful anal. of the results of different fits and a comparison with the ab initio optimizations confirms the validity of the used methods, providing detailed structural information on the title compound and the disulfide bridge. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7Quality Control of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Quality Control of 1,2-Diphenyldisulfane They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Dyes and Pigments included an article by Liu, Yuan; Tao, Chen; Xie, Guohua; Van Der Velden, Jeroen; Marras, Sergio; Luo, Zhenghui; Zeng, Xuan; Petrozza, Annamaria; Yang, Chuluo. Product Details of 101-70-2. The article was titled 《Hexa-substituted benzene derivatives as hole transporting materials for efficient perovskite solar cells》. The information in the text is summarized as follows:

Two low cost hexa-substituted benzene derivatives, HFB-OMeDPA and HPB-OMeDPA, have been successfully used as hole transporting materials (HTMs) for efficient perovskite solar cells (PSCs). The relations between mol. structure, electronic properties of the semiconductor and eventually the photovoltaic performance are studied. The planar PSCs employing HPB-OMeDPA as HTM exhibit excellent power conversion efficiencies exceeding 16% under AM 1.5 G illumination conditions, which are comparable to the reference cells based on spiro-OMeTAD.Bis(4-methoxyphenyl)amine(cas: 101-70-2Product Details of 101-70-2) was used in this study.

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Product Details of 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Catalysis included an article by Peng, Jin-Bao; Wu, Fu-Peng; Li, Da; Geng, Hui-Qing; Qi, Xinxin; Ying, Jun; Wu, Xiao-Feng. Safety of 1-Iodo-2-methoxybenzene. The article was titled 《Palladium-Catalyzed Regioselective Carbonylative Coupling/Amination of Aryl Iodides with Unactivated Alkenes: Efficient Synthesis of β-Aminoketones》. The information in the text is summarized as follows:

The carbonylative coupling of aryl halides with unactivated alkenes remains a challenge, because of the low reactivity of acyl-palladium intermediate to the olefins. A palladium-catalyzed carbonylative coupling/amination of aryl iodides with unactivated alkenes for the synthesis of β-aminoketone derivatives was developed. With the assistance of a directing group (8-aminoquinoline, AQ), the coordination of the olefin to acyl-palladium complex can be enhanced, thereby promoting the acylpalladation across the C:C double bonds. A broad range of β-aminoketone derivatives were prepared in moderate to excellent yields with complete regioselectivity by using 4-pentenoic and 2-vinylbenzoic amide derivatives as the starting materials. This methodol. involves the formation of two C-C bonds as well as one C-N bond, and provided a method for the carbonylative difunctionalization of unactivated alkenes. In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2Safety of 1-Iodo-2-methoxybenzene) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Safety of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem