Tag: 200-300

In 2019,ChemistrySelect included an article by Jori, Popat K.; Jadhav, Vrushali H.. Safety of 1-Iodo-2-methoxybenzene. The article was titled 《Transition-Metal-Free Glucose-Derived Carbonaceous Catalyst Catalyzes Direct C-H Arylation of Unactivated Arenes with Aryl Halides》. The information in the text is summarized as follows:

The metal free catalyst by a very simple, economical and greener method was prepared The green catalyst showed remarkable activity in developing a simple and efficient method for C-H arylation of benzene with number of aryl halides RI (R = 3-methylphenyl, 4-chlorophenyl, naphth-1-yl, biphenyl-4-yl, etc.) in the synthesis of biaryls RC6H5. This method can be used to generate a diverse range of biaryl’s in good to excellent yields. The experimental process involved the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Safety of 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Safety of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2014,Zhang, Hong-Wu; Wang, Li-Qin; Xiang, Qing-Feng; Zhong, Qian; Chen, Lu-Ming; Xu, Cai-Xia; Xiang, Xian-Hong; Xu, Bo; Meng, Fei; Wan, Yi-Qian; Deng, David Y. B. published 《Specific lipase-responsive polymer-coated gadolinium nanoparticles for MR imaging of early acute pancreatitis》.Biomaterials published the findings.Product Details of 139115-91-6 The information in the text is summarized as follows:

Currently, available methods for diagnosis of acute pancreatitis (AP) are mainly dependent on serum enzyme anal. and imaging techniques that are too low in sensitivity and specificity to accurately and promptly diagnose AP. The lack of early diagnostic tools highlights the need to search for a highly effective and specific diagnostic method. In this study, we synthesized a conditionally activated, gadolinium-containing, nanoparticle-based MRI nanoprobe as a diagnostic tool for the early identification of AP. Gadolinium diethylenetriaminepentaacetic fatty acid (Gd-DTPA-FA) nanoparticles were synthesized by conjugation of DTPA-FA ligand and gadolinium acetate. Gd-DTPA-FA exhibited low cytotoxicity and excellent biocompatibility when characterized in vitro and in vivo studies. L-arginine induced a gradual increase in the intensity of the T1-weighted MRI signal from 1 h to 36 h in AP rat models. The increase in signal intensity was most significant at 1 h, 6 h and 12 h. These results suggest that the Gd-DTPA-FA as an MRI contrast agent is highly efficient and specific to detect early AP. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Product Details of 139115-91-6 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2021,CCS Chemistry included an article by Tang, Xiaowen; Luo, Xiang; Su, Qiong; Wei, Gaofei; Meng, Shan-Shui; Chan, Albert S. C.. Name: 2-Hydroxy-2-(4-propoxyphenyl)acetic acid. The article was titled 《Chemoselective dual functionalization of phenols via relay catalysis of borane with different forms》. The information in the text is summarized as follows:

A highly efficient and chemoselective dual functionalization of unprotected phenols with α- or β- hydroxyl acids was presented. A variety of valuable benzofuranones and dihydrocoumarins were delivered in moderate to high yields. D. functional theory (DFT) calculations and control experiments indicated that an untypical Friedel-Crafts alkylation and the subsequent lactonization were catalyzed by the Lewis acid form and the Bronsted acid form of borane, resp. Gram-scale experiments and late-stage functionalization of complex mols. were performed to highlight the utility of this reaction. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-2-(4-propoxyphenyl)acetic acid(cas: 79694-16-9Name: 2-Hydroxy-2-(4-propoxyphenyl)acetic acid)

2-Hydroxy-2-(4-propoxyphenyl)acetic acid(cas: 79694-16-9) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: 2-Hydroxy-2-(4-propoxyphenyl)acetic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Tri- and tetravalent photoactivable cross-linking agents》 was written by Welle, Alexandre; Billard, Francois; Marchand-Brynaert, Jacqueline. Related Products of 139115-91-6This research focused ontrivalent tetravalent photoactivable cross linking agent preparation. The article conveys some information:

A modular synthesis of photoactivable crosslinking agents is described, using an aromatic core, di- or triethyleneglycol spacers and photoaffinity labeling synthons that feature either perfluorophenyl azide or aryl(trifluoromethyl)diazirine motifs. Sym. and nonsym. trivalent structures, e.g. I [L = CH2CH2OCH2CH2NH], were obtained from phloroglucinol and dopamine, resp. Sym. tetravalent structures resulted from the coupling of two dopamine derivatives with oxalyl chloride. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Related Products of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sun, Zhu-Zhu; Feng, Shuai; Ding, Wei-Lu; Peng, Xing-Liang; Guan, Jian; Zhao, Zhiqiang published an article in 2021. The article was titled 《Molecular design of dibenzo[g,p]chrysene-based hole-transporting materials for perovskite solar cells: A theoretical study》, and you may find the article in Synthetic Metals.Quality Control of Bis(4-methoxyphenyl)amine The information in the text is summarized as follows:

Designed with a steric twisted, π-conjugated dibenzochrysene (DBC) core and arylamine-based electron-donating side arms, four small mols. as hole-transporting materials (HTMs) are simulated with d. functional theory and Marcus theory of electron transfer. Our results show that, adding the fluorene moiety in auxiliary side arms and extending the π-conjugated structure can make the HOMO (HOMO) energy levels down-shifted. By tailoring of electron-donating side arms, the HOMO levels of designed HTMs range from -4.95 to -5.24 eV, which affords a chance for the interfacial energy regulation. Meanwhile, we also find that the suitable extension of π-conjugated side arms and the accessorial sulfur-sulfur interaction may be beneficial for promoting the intermol. electronic coupling. Coupled with the lower reorganization energy, the DBC-4 (7.08 x 10-1 cm2 v-1 s-1) displays the largest hole mobility. In addition, the better solubility can be expected for the DBC-4 due to the larger solvation free energy, whereas its stability may be somewhat lower. Adding thiophene unit in side arms makes the absorption spectra obviously red-shift. Overall, this work provides some useful clues for designing of high-efficient HTMs, and the DBC-4 is proposed as potential HTM. In the experiment, the researchers used many compounds, for example, Bis(4-methoxyphenyl)amine(cas: 101-70-2Quality Control of Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Quality Control of Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Panchenko, Pavel A.; Efremenko, Anastasija V.; Feofanov, Alexey V.; Ustimova, Mariya A.; Fedorov, Yuri V.; Fedorova, Olga A. published an article in 2021. The article was titled 《Ratiometric detection of mercury (II) ions in living cells using fluorescent probe based on Bis(styryl) dye and azadithia-15-crown-5 ether receptor》, and you may find the article in Sensors.Recommanded Product: 33100-27-5 The information in the text is summarized as follows:

Bis(styryl) dye 1 bearing N-phenylazadithia-15-crown-5 ether receptor has been evaluated as a ratiometric fluorescent chemosensor for mercury (II) ions in living cells. In aqueous solution, probe 1 selectively responds to the presence of Hg2+ via the changes in the emission intensity as well as in the emission band shape, which is a result of formation of the complex with 1:1 metal to ligand ratio (dissociation constant 0.56 ± 0.15 μM). The sensing mechanism is based on the interplay between the RET (resonance energy transfer) and ICT (intramol. charge transfer) interactions occurring upon the UV/Vis (380 or 405 nm) photoexcitation of both styryl chromophores in probe 1. Bio-imaging studies revealed that the yellow (500-600 nm) to red (600-730 nm) fluorescence intensity ratio decreased from 4.4 ± 0.2 to 1.43 ± 0.10 when cells were exposed to increasing concentration of mercury (II) ions enabling ratiometric quantification of intracellular Hg2+ concentration in the 37 nM-1 μM range. In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of oxygen-heterocycles having linker components for trapping cysteine derivatives》 was written by Yoshioka, Eito; Minato, Ikko; Takashima, Hideki; Miyabe, Hideto. Computed Properties of C9H19NO4 And the article was included in Heterocycles in 2020. The article conveys some information:

Tricyclic oxygen-heterocycles having a linker component were synthesized for the site-specific modification of proteins and peptides. The linker components were initially introduced by Sonogashira-Hagihara cross coupling of 5-bromo-2-hydroxybenzaldehyde and a variety of alkynes. Next, the desired oxygen-heterocycles were synthesized by the condensation reaction of coupling products with cyclohexane-1,3-dione in the presence of N,N-diisopropylethylamine. Finally, the trapping ability of these oxygen-heterocycles was demonstrated by the representative reaction of 7-(3-(benzyloxy)prop-1-yn-1-yl)-4a-hydroxy-2,3,4,4a-tetrahydro-1H-xanthen-1-one with glutathione as a nucleophile having a thiol group. In the experiment, the researchers used many compounds, for example, tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Computed Properties of C9H19NO4Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Online High-Performance Liquid Chromatography Analysis of Buchwald-Hartwig Aminations from within an Inert Environment》 was written by Malig, Thomas C.; Yunker, Lars P. E.; Steiner, Sebastian; Hein, Jason E.. Formula: C14H15NO2 And the article was included in ACS Catalysis in 2020. The article conveys some information:

Obtaining data-dense reaction profiles for reactions performed under an inert atm. remains a significant challenge obfuscating mechanistic anal. To this end, we have developed a reaction monitoring platform capable of automated sampling and online HPLC anal. to generate temporal profiles for reactions performed from within a glovebox. The device allows for facile reaction progress anal. to aid in mechanistic studies of air-sensitive chem. transformations. The platform has demonstrated high reproducibility regarding sample mixing, dilution, delivery, and anal. We employed the sampling platform to acquire temporal profiles for a series of Buchwald-Hartwig aminations. Parallel coupling reactions using iodobenzene and bromobenzene both exhibit complex kinetics. A competition reaction including both aryl halides demonstrated high selectivity for iodobenzene indicative of catalyst monopoly. The temporal profile for the difunctionalized substrate 1,4-iodobromobenzene was unexpected based on our parallel and competition studies and is indicative of a distinct underlying mechanism. We attribute this unanticipated reactivity to intramol. catalyst transfer through the π system as seen in “”living”” polymerization transfer catalyst systems. The use of this automated sampling platform has greatly increased mechanistic understanding despite performing only a small number of experiments In the experimental materials used by the author, we found Bis(4-methoxyphenyl)amine(cas: 101-70-2Formula: C14H15NO2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Formula: C14H15NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《S-(4-Methoxyphenyl)-4-methoxybenzenesulfonothioate as a Promising Lead Compound for the Development of a Renal Carcinoma Agent》 was written by Nantes, Camilla I.; Pereira, Ingrid D.; Bai, Ruoli; Hamel, Ernest; Burnett, James C.; de Oliveira, Rodrigo J.; Matos, Maria de F. C.; Beatriz, Adilson; Yonekawa, Murilo K. A.; Perdomo, Renata T.; de Lima, Denis P.; Bogo, Danielle; dos Santos, Edson dos A.. COA of Formula: C12H10S2 And the article was included in ChemMedChem in 2020. The article conveys some information:

Organosulfur compounds show cytotoxic potential towards many tumor cell lines. Disulfides and thiosulfonates act through apoptotic processes, inducing proteins associated with apoptosis, endoplasmic reticulum stress, and the unfolded protein response. Three p-substituted sym. diaryl disulfides and three diaryl thiosulfonates were synthesized and analyzed for inhibition of tubulin polymerization and for human cancer cell cytotoxic activity against seven tumor cell lines and a non-tumor cell line. S-(4-methoxyphenyl)-4-methoxybenzenesulfonothioate (6) exhibited inhibition of tubulin polymerization and showed the best antiproliferative potential, especially against the 786-0 cell line, being six times more selective as compared with the non-tumor cell line. In addition, compound 6 was able to activate caspase-3 after 24 and 48 h treatments of the 786-0 cell line and induced cell-cycle arrest in the G2/M stage at the highest concentration evaluated at 24 and 48 h. Compound 6 was able to cause complete inhibition of proliferation, inducing the death of 786-0 cells, by increasing the number of cells at G2/M and greater activation of caspase-3. The experimental process involved the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7COA of Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. COA of Formula: C12H10S2 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《D-p-D molecular semiconductors for perovskite solar cells: the superior role of helical versus planar p-linkers》 was written by Xu, Niansheng; Zheng, Aibin; Wei, Yuefang; Yuan, Yi; Zhang, Jing; Lei, Ming; Wang, Peng. Recommanded Product: Bis(4-methoxyphenyl)amine And the article was included in Chemical Science in 2020. The article conveys some information:

Controlling the mode of mol. packing and the size of mol. aggregates is of fundamental importance for high-performance charge transport materials in next-generation optoelectronic devices. To clarify the peculiar role of helicene as a kernel block in the exploration of unconventional organic semiconductors, in this work thia[5]helicene (T5H) is doubly aminated with electron-donating dimethoxydiphenylamine to afford T5H-OMeDPA, which is systematically compared with its perylothiophene (PET) congener (PET-OMeDPA). On the basis of the quantum theory of atoms in mols. and energy decomposition anal. of single crystals, it is surprisingly found that while p-p stacking of planar PET is stronger than that of helical T5H, this desirable effect for the charge transport of organic semiconductors is completely lost for donor-p-donor (D-p-D) type PET-OMeDPA but is retained for T5H-OMeDPA to a large extent. Consequently, the T5H-OMeDPA single-crystal presents about 5 times higher theor. hole-mobility than PET-OMeDPA. With respect to PET-OMeDPA, there is a weaker electronic coupling of helical T5H-OMeDPA with perovskites, leading to reduced interfacial charge recombination. Due to reduced transport resistance and enhanced recombination resistance, perovskite solar cells with T5H-OMeDPA exhibit a power conversion efficiency of 21.1%, higher than 19.8% with PET-OMeDPA and 20.6% with the spiro-OMeTAD control. In the experiment, the researchers used many compounds, for example, Bis(4-methoxyphenyl)amine(cas: 101-70-2Recommanded Product: Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Recommanded Product: Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem