In 2021,CCS Chemistry included an article by Tang, Xiaowen; Luo, Xiang; Su, Qiong; Wei, Gaofei; Meng, Shan-Shui; Chan, Albert S. C.. Name: 2-Hydroxy-2-(4-propoxyphenyl)acetic acid. The article was titled 《Chemoselective dual functionalization of phenols via relay catalysis of borane with different forms》. The information in the text is summarized as follows:
A highly efficient and chemoselective dual functionalization of unprotected phenols with α- or β- hydroxyl acids was presented. A variety of valuable benzofuranones and dihydrocoumarins were delivered in moderate to high yields. D. functional theory (DFT) calculations and control experiments indicated that an untypical Friedel-Crafts alkylation and the subsequent lactonization were catalyzed by the Lewis acid form and the Bronsted acid form of borane, resp. Gram-scale experiments and late-stage functionalization of complex mols. were performed to highlight the utility of this reaction. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-2-(4-propoxyphenyl)acetic acid(cas: 79694-16-9Name: 2-Hydroxy-2-(4-propoxyphenyl)acetic acid)
2-Hydroxy-2-(4-propoxyphenyl)acetic acid(cas: 79694-16-9) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: 2-Hydroxy-2-(4-propoxyphenyl)acetic acid
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem