Tag: 200-300

In 2012,de Graaf, Albert J.; Mastrobattista, Enrico; Vermonden, Tina; van Nostrum, Cornelus F.; Rijkers, Dirk T. S.; Liskamp, Rob M. J.; Hennink, Wim E. published 《Thermosensitive Peptide-Hybrid ABC Block Copolymers Obtained by ATRP: Synthesis, Self-Assembly, and Enzymatic Degradation》.Macromolecules (Washington, DC, United States) published the findings.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Peptide-hybrid ABC block copolymers were synthesized by growing two different polymer chains from a native peptide using atom transfer radical polymerization (ATRP). To this end, two different ATRP initiators were coupled via orthogonal methods to the N- and C-terminus of the peptide Ser-Gly-Pro-Gln-Gly-Ile-Phe-Gly-Gln-Met-Gly, a substrate for matrix metalloproteases 2 and 9. First, a hydrophilic block of poly(oligo(ethylene glycol) Me ether methacrylate) (pOEGMA) was polymerized from the peptide’s C-terminus. Before polymerization of the second block, the first living chain end was inactivated by substitution of its Cl-terminus with azide under mild conditions. Then, a thermosensitive block of poly(N-isopropylacrylamide) (pNIPAm) was polymerized from the peptide’s N-terminus. Well-defined polymers were obtained with good control over both block sizes. The resulting polymers self-assembled into micelles above the cloud point of the pNIPAm block. As anticipated, it was shown that the peptide linkage between the polymer blocks can be cut by a metalloprotease, leading to “”shedding”” of the corona of the micelles which makes these systems potentially suitable for enzyme-triggered drug delivery. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ding, Xingdong; Wang, Haoxin; Chen, Cheng; Li, Hongping; Tian, Yi; Li, Qijun; Wu, Cheng; Ding, Liming; Yang, Xichuan; Cheng, Ming published an article in 2021. The article was titled 《Passivation functionalized phenothiazine-based hole transport material for highly efficient perovskite solar cell with efficiency exceeding 22%》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Related Products of 101-70-2 The information in the text is summarized as follows:

Hole transport material (HTM) is an indispensable part of highly efficient perovskite solar cells (PSC). Designing new HTMs with suitable energy levels and desired electronic properties is critical to realize efficient and stable PSCs. Herein, two phenothiazine (PTZ) core building block based HTMs, termed PTZ-Py and PTZ-Bz, are reported. Applied in PSCs, the research results manifest that the introduced pyridine group, on the one hand, can deeply impact the electronic properties (energy levels and charge carrier mobility) and film-forming property; on the other hand, can efficiently passivate the perovskite surface defects, in turn, enhance the power conversion efficiency (PCE) and device stability. Under the optimized fabrication conditions, the HTM PTZ-Py based PSC obtains the highest PCE of 19.9%, and maintains around 90% initial efficiency after 1000 h aging in ambient condition with RH 50-65%. By using PTZ-Py as interface layer together with Spiro-OMeTAD, an improved PCE of 22.1% was obtained. The results came from multiple reactions, including the reaction of Bis(4-methoxyphenyl)amine(cas: 101-70-2Related Products of 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Related Products of 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computed Properties of C12H10S2In 2020 ,《Metal-free regioselective C-H chalcogenylation of coumarins/(hetero)arenes at ambient temperature》 was published in Chemical Communications (Cambridge, United Kingdom). The article was written by Song, Zengqiang; Ding, Chaochao; Wang, Shaoli; Dai, Qian; Sheng, Yaoguang; Zheng, Zhilong; Liang, Guang. The article contains the following contents:

A novel, practical and metal-free approach for the regioselective selenation of coumarins I [R = H, OMe; R1 = Me, Ph, Br, etc.; R2 = H, Me, OMe, Cl, OAc; R3 = Me, F, Cl, etc.; R4 = H, Me; R2R3 = CH=CH-CH=CH, -(CH2)4-] employing (bis(trifluoroacetoxy)iodo)benzene (PIFA) at room temperature is presented. The developed method is suitable for a wide substrate scope and affords 3-selenyl coumarins II (R5 = Et, Ph, 2-methoxypyridin-3-yl, etc.) in good to excellent yields with high selectivity. A radical mechanism is proposed for this new transformation. Furthermore, the application of sulfenylation with coumarines I and selenation with other (hetero)arenes e.g.,1H-indazole in this transformation is successful. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Computed Properties of C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Computed Properties of C12H10S2 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bhuyar, Prakash; Rahim, Mohd hasbi ab.; Maniam, Gaanty pragas; Govindan, Natanamurugaraj published their research in Journal of Microbiology, Biotechnology and Food Sciences in 2021. The article was titled 《Isolation and characterization of bioactive compounds in medicinal plant Centella asiatica and study the effects on fungal activities》.Computed Properties of C10H20O5 The article contains the following contents:

Medicinal plants are sources of important therapeutic aids for alleviating human ailments. The present research investigation was carried out to study anti-fungal activity of C. asiatica were tested against C. albicans, Aspergillus niger, and Penicillium sp. using two methods, disk diffusion method and broth dilution method. C. asiatica crude methanol extract was found to be the most effective against fungal activity. Compared to disk diffusion, broth dilution was a more appropriate method to quant. determine the anti-Candida activity of plant extract, whereby the MIC values of the crude extracts was determined The result from disk diffusion assay demonstrates that plant extracts have an inhibitory effect. However, the broth dilution method result reveal that C. asiatica crude methanol extract has lower MIC values, meaning it has more prove that C. asiatica has an anti-fungal effect. Bioactive anal. results reveled that bioactive compounds present in the leaf, stems, roots, and the whole plant extract from Centella asiatica are the major chem. constituents are n-Hexadecanoic acid (99%), cis-Vaccenic acid (91%), 5-Hydroxymethylfurfural (88%), Tetradecanoic acid (86%). Further study is required to find out the specific phytochem. which is responsible for its medicinal value. In the part of experimental materials, we found many familiar compounds, such as 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Computed Properties of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Computed Properties of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Comments on chemical properties reported for diphenyl disulfide and its derivatives: The merit of the phenyl groups》 was published in Journal of the Chinese Chemical Society (Weinheim, Germany) in 2020. These research results belong to Lin, Hung-Sung; Wu, Yan; Liu, Yu-Ju; Chen, Shu-Hui; Chen, Wei-Ting; Wang, Shao-Pin. SDS of cas: 882-33-7 The article mentions the following:

The sym. 2,2′-disubstitued derivatives of di-Ph disulfide showing widely spanning rates of electrophilic attack of the HIV-1 nucleocapsid protein p7 zinc fingers have been rationalized, based on the LUMO (LUMO)-lowering approach, by the substituents′ π-effects and the hydrogen bond stabilization effects. In the 2,2′-amide- and 4,4′-N-amide-substituted derivatives, the extent of LUMO lowering has been reduced by the destabilization of lone-pair bond orbital, lp(N), present on the nitrogen atom of N-amide. From the natural bond orbital viewpoint, hydrogen bond stabilization of LUMO is mainly governed by stabilization of the σ*SS bond orbital. The experimental process involved the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7SDS of cas: 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.SDS of cas: 882-33-7Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C10H10O5On November 30, 1982 ,《Acid-labile resin linkage agents for use in solid phase peptide synthesis》 appeared in International Journal of Peptide & Protein Research. The author of the article were Sheppard, Robert C.; Williams, Brian J.. The article conveys some information:

Acid-labile peptide-resin linkage agents I (R = H, OMe) were prepared from 4-formylphenol (II) and 3-methoxyphenol (III), resp. Thus, III was formylated with POCl3/DMF to give benzaldehyde IV (R1 = H), which was treated with ClCH2CO2H in the presence of aqueous NaOH to give IV (R1 = CH2CO2H), which was reduced by NaBH4 to give I (R = OMe). II was treated with ClCH2CO2H to give 4-HCOC6H4OCH2CO2H, which was reduced by NaBH4 to give I (R = H). I (R = OMe) is suitable for the preparation of peptide fragments having tert-Bu-based side-chain protective groups. In addition to this study using 2-(4-Formyl-3-methoxyphenoxy)acetic acid, there are many other studies that have used 2-(4-Formyl-3-methoxyphenoxy)acetic acid(cas: 84969-24-4Formula: C10H10O5) was used in this study.

2-(4-Formyl-3-methoxyphenoxy)acetic acid(cas: 84969-24-4) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C10H10O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A trifluoromethylphenyl diazirine-based SecinH3 photoaffinity probe》 was written by Albertoni, Barbara; Hannam, Jeffrey S.; Ackermann, Damian; Schmitz, Anton; Famulok, Michael. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateThis research focused ontrifluoromethylphenyl diazirine SecinH3 photoaffinity probe cytohesin. The article conveys some information:

The synthesis of a trifluoromethylphenyl diazirine photoaffinity probe of the cytohesin inhibitor SecinH3 is described. The probe exhibits improved labeling efficiency over a benzophenone-based probe and thus is more suitable for photoaffinity labeling in complex biol. samples. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C9H19NO4In 2016 ,《Protein-Coupled Fluorescent Probe To Visualize Potassium Ion Transition on Cellular Membranes》 appeared in Analytical Chemistry (Washington, DC, United States). The author of the article were Hirata, Tomoya; Terai, Takuya; Yamamura, Hisao; Shimonishi, Manabu; Komatsu, Toru; Hanaoka, Kenjiro; Ueno, Tasuku; Imaizumi, Yuji; Nagano, Tetsuo; Urano, Yasuteru. The article conveys some information:

K+ is the most abundant metal ion in cells, and changes of [K+] around cell membranes play important roles in physiol. events. However, there is no practical method to selectively visualize [K+] at the surface of cells. To address this issue, we have developed a protein-coupled fluorescent probe for K+, TLSHalo. TLSHalo is responsive to [K+] in the physiol. range, with good selectivity over Na+ and retains its K+-sensing properties after covalent conjugation with HaloTag protein. By using cells expressing HaloTag on the plasma membrane, we successfully directed TLSHalo specifically to the outer surface of target cells. This enabled us to visualize localized extracellular [K+] change with TLSHalo under a fluorescence microscope in real time. To confirm the exptl. value of this system, we used TLSHalo to monitor extracellular [K+] change induced by K+ ionophores or by activation of a native Ca2+-dependent K+ channel (BK channel). Further, we show that K+ efflux via BK channel induced by elec. stimulation at the bottom surface of the cells can be visualized with TLSHalo by means of total internal reflection fluorescence microscope (TIRFM) imaging. Our methodol. should be useful to analyze physiol. K+ dynamics with high spatiotemporal resolution In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Synthetic Route of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Synthetic Route of C9H19NO4 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 882-33-7In 2020 ,《Visible light catalyzed anti-markovnikov hydration of styrene to 2-phenylethanol: From batch to continuous》 was published in Journal of Photochemistry and Photobiology, A: Chemistry. The article was written by Chen, Yuhang; Zhang, Jie; Tang, Zhiyong; Sun, Yuhan. The article contains the following contents:

The 2-phenylethanol production by traditional chem. methods requires multi-step reactions, in which harsh conditions such as high temperature or strong acid/base are required and undesired byproducts are easily produced. The visible light catalyzed anti-Markovnikov hydration of styrene is a single-step reaction using non-toxic catalyst under mild conditions. However, this reaction usually takes ten or even dozens of hours, facing the problem in scale up. The present work aims to intensify this reaction in continuous flow microreactor with comparison to traditional batch reactor. The effects of light source shape, reaction temperature, substrate concentration and catalyst concentration on the reaction were investigated. The continuous flow microreactor permitted to ensure more uniform light intensity and larger sp. surface area, the reaction rate could thus be enhanced. The maximum productivity of 2-phenylethanol was 0.122 mol/(L.h), which was 2.5 times higher than that obtained in test tube under the same reaction conditions and 34 times higher than that reported in previous literature. The optimal photosensitizer concentration was 2%. The increase of substrate concentration would lead to the addition reaction between styrene cationic intermediates with styrene, thereby decreasing the selectivity of 2-phenylethanol. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7Product Details of 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Product Details of 882-33-7 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A Z-type PGeP pincer germylene ligand in a T-shaped palladium(0) complex》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Cabeza, Javier A.; Garcia-Alvarez, Pablo; Laglera-Gandara, Carlos J.; Perez-Carreno, Enrique. Name: 1,2-Diphenyldisulfane The article mentions the following:

A dipyrromethane-based germylene decorated with two phosphine groups has been used to prepare an unusual T-shaped palladium(0) containing a PGeP pincer germylene that acts as a Z-type ligand. This compound is a strong reducing reagent, as it has been easily oxidized to germyl-palladium(II) derivatives with a gold(I) complex, HCl and Ph2S2 through processes that involve formal addition of a bond of the oxidant across the Ge-Pd bond. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Name: 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Name: 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem