Tag: 200-300

Insights into Soluble Guanylyl Cyclase Activation Derived from Improved Heme-Mimetics was written by von Wantoch Rekowski, Margarete;Kumar, Vijay;Zhou, Zongmin;Moschner, Johann;Marazioti, Antonia;Bantzi, Marina;Spyroulias, Georgios A.;van den Akker, Focco;Giannis, Athanassios;Papapetropoulos, Andreas. And the article was included in Journal of Medicinal Chemistry in 2013.Recommanded Product: 156635-90-4 This article mentions the following:

Recently, the structure of BAY 58-2667 bound to the Nostoc sp. H-NOX domain was published. On the basis of this structural information, we designed BAY 58-2667 derivatives and tested their effects on soluble guanylyl cyclase (sGC) activity. Derivative 20 activated sGC 4.8-fold more than BAY 58-2667. Co-crystallization of 20 with the Ns H-NOX domain revealed that the increased conformational distortion at the C-terminal region of αF helix containing 110-114 residues contributes to the higher activation triggered by 20. In the experiment, the researchers used many compounds, for example, (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4Recommanded Product: 156635-90-4).

(4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 156635-90-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A convenient method for synthesis of 1,1-diisopropoxycyclohexane was written by Gao, Jinliang;Li, Xianggao;Hu, Cong;Wang, Shirong;Feng, Yaqing. And the article was included in Jingxi Huagong in 2007.Application In Synthesis of 1,1-Diisopropoxycyclohexane This article mentions the following:

A method for the synthesis of the title compound [i.e., cyclohexanone diisopropyl ketal, 1,1-bis(1-methylethoxy)cyclohexane] is reported here. A one-pot reaction of cyclohexanone with tri-Me orthoformate using p-toluenesulfonic acid as catalyst in isopropanol provided 1,1-dimethoxycyclohexane. This compound (without separation) reacted further with isopropanol to form the title compound by distilling off the low-boiling product. Structure of the title compound was characterized by elementary anal., ¹HNMR and IR. The optimized process conditions and results were n(cyclohexanone) : n(tri-Me orthoformate) : n(isopropanol) : n(p-toluenesulfonic acid) = 1:1.1:4:0.007, number of theor. plates 5, reaction time 15 h, yield 61.5% and GC content 96.4% (area normalization method). In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Application In Synthesis of 1,1-Diisopropoxycyclohexane).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application In Synthesis of 1,1-Diisopropoxycyclohexane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Solvent-free iodination of arenes at room temperature was written by Alexander, Varughese M.;Khandekar, Amit C.;Samant, Shriniwas D.. And the article was included in Synlett in 2003.Related Products of 75581-11-2 This article mentions the following:

Silica supported bismuth(III)nitrate pentahydrate (BNP-SiO₂) was prepared under simple co-grinding condition. The iodination of aromatic compounds using BNP-SiO₂ and mol. iodine under solvent-free conditions is described. The reaction occurred in the solid state at room temperature, yielding the corresponding mono-iodo derivative in good yields. However, less activated aromatics required longer reaction time with comparatively less yield. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Related Products of 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tetra-Branched Tetra-Cationic Ionic Liquids: Effects of Spacer and Tail Structure on Physical Properties was written by Ikeda, Taichi. And the article was included in Bulletin of the Chemical Society of Japan in 2020.Synthetic Route of C11H22O5 This article mentions the following:

Herein, the synthesis of ten tetra-branched tetra-cationic ionic liquids, which consist of a pentaerythritol-based core, alkylene or ethylenedioxy spacers, imidazolium cationic units, and short alkyl tails, is described. The phys. properties of the tetra-cations, including their glass transition and thermal decomposition temperatures, densities, viscosities, and ionic conductivities, were investigated. The tetra-cations were analyzed to determine the effects of the spacer and tail structure on the above-mentioned phys. properties. The spacer unit located between the pentaerythrityl core and cationic unit was confirmed to be the key for improving ionic conductivity A maximum ionic conductivity of 2.8 x 10-4 S cm-1 (25°C under anhydrous conditions) and a min. viscosity of 1.6 Pa s (25°C) were observed While the phys. values of the tetra-cationic ionic liquids are close to those of di-cationic ionic liquids, their structure-property relationship is similar to that of poly-cations rather than di-cations. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Synthetic Route of C11H22O5).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Synthetic Route of C11H22O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electrochemical oxidation of catechol in the presence of some azacrown ethers and transition metal ions in acetonitrile was written by Nematollahi, Davood;Mohammadi-Behzad, Leila. And the article was included in International Journal of Electrochemical Science in 2009.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

The electrochem. oxidation of catechol (H₂Q) has been studied in the absence and presence of 1,10.diaza-18-crown-6 (DA18C6), 1,7-diaza-15-crown-5 (DA15C5) and aza-15-crown-5 (A15C5) and also, in the presence of some transition metal ions (Zn²⁺, Ni²⁺ and Cd²⁺) in acetonitrile containing tetra-n-butylammonium perchlorate as supporting electrolyte, by means of cyclic voltammetry. The results indicate an ECCE(E)C mechanism in electrochem. oxidation of catechol (H₂Q) in the presence of azacrown ethers a-c. The cyclic voltammetric data were analyzed by digital simulation to confirm and to measure the homogeneous parameters for the suggested electrode mechanism. The calculated observed homogeneous rate constants (k_obs) for the reaction of electrochem. generated cation radical (H₂Q⁺) with azacrown ethers 2a-c was found to vary in the order DA18C6 >DA15C5 >A15C5. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cross-Coupling in Flow using Supported Catalysts: Mild, Clean, Efficient and Sustainable Suzuki-Miyaura Coupling in a Single Pass was written by Munoz, Juan de M.;Alcazar, Jesus;de la Hoz, Antonio;Diaz-Ortiz, Angel. And the article was included in Advanced Synthesis & Catalysis in 2012.Recommanded Product: 365564-07-4 This article mentions the following:

A mild, clean, practical, sustainable and high yielding procedure for Suzuki-Miyaura cross-coupling in a single pass using a silica-supported palladium catalyst is described. The catalyst can be used in more than 30 reactions and for more than 8 h of continuous processing without a decrease in reactivity due to the low leaching observed Different halides/pseudo-halides and organoboron compounds can be used without modifying the standard procedure. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Recommanded Product: 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Palladium(II)-Catalyzed Direct ortho-C-H Acylation of Anilides by Oxidative Cross-Coupling with Aldehydes using tert-Butyl Hydroperoxide as Oxidant was written by Chan, Chun-Wo;Zhou, Zhongyuan;Yu, Wing-Yiu. And the article was included in Advanced Synthesis & Catalysis in 2011.Quality Control of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

An efficient palladium-catalyzed C-H acylation with aldehydes using tert-Bu hydroperoxide (TBHP) transforms various anilides into synthetically useful 2-aminobenzophenone derivatives under mild conditions (40°, 3 h). The acylation reaction exhibits excellent regioselectivity and functional group tolerance, and simple aromatic aldehydes, functionalized aliphatic aldehydes and heteroaromatic aldehydes are effective coupling partners. The acylation reaction is probably initiated by a rate-limiting electrophilic C-H cyclopalladation (k_H/k_D=3.6; ρ⁺=-0.74) to form an arylpalladium complex, followed by acyl radical functionalization. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Quality Control of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Friedlander synthesis of substituted quinolines from N-pivaloylanilines was written by Ubeda, J. Ignacio;Villacampa, Mercedes;Avendano, Carmen. And the article was included in Synthesis in 1998.Product Details of 56619-93-3 This article mentions the following:

Quinolines were synthesized by lithiation of N-pivaloylanilines with sec-BuLi, formylation with DMF, and subsequent condensation with active methylene groups of aldehydes or ketones (KHMDS). The pivaloyloxy group is eliminated during the 1-pot procedure in most cases. The scope of the reaction was studied, showing that the method is limited by the nature of intermediate compounds In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Product Details of 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Product Details of 56619-93-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A Mild and Ligand-Free Ni-Catalyzed Silylation via C-OMe Cleavage was written by Zarate, Cayetana;Nakajima, Masaki;Martin, Ruben. And the article was included in Journal of the American Chemical Society in 2017.SDS of cas: 365564-07-4 This article mentions the following:

Metal-catalyzed transformations that forge carbon-heteroatom bonds are of central importance in organic synthesis. Despite the formidable potential of aryl Me ethers as coupling partners, the scarcity of metal-catalyzed C-heteroatom bond formations via C-OMe cleavage is striking, with isolated precedents requiring specialized, yet expensive, ligands, high temperatures, and π-extended backbones. Authors report an unprecedented catalytic ipso-silylation of aryl Me ethers under mild conditions and without recourse to external ligands. The method is distinguished by its wide scope, which includes the use of benzyl Me ethers, vinyl Me ethers, and unbiased anisole derivatives, thus representing a significant step forward for designing new C-heteroatom bond formations via C-OMe scission. Applications of this transformation in orthogonal silylation techniques as well as in further derivatizations are also described. Preliminary mechanistic experiments suggest the intermediacy of Ni(0)-ate complexes, leaving some doubt that a canonical catalytic cycle consisting of an initial oxidative addition of the C-OMe bond to Ni(0) species comes into play. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4SDS of cas: 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).SDS of cas: 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The drastic effect of cobalt and chromium catalysts in the borylation of arylzinc reagents was written by Komeyama, Kimihiro;Kiguchi, Shinnosuke;Takaki, Ken. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Application In Synthesis of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

A new synthetic approach to arylboronic esters from arylzinc reagents with boryl electrophiles MeOB(OR)₂ was developed. Also, this protocol could be applied to the cyclization/borylation of alkynylaryl iodides to afford cyclized vinylboronic esters. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Application In Synthesis of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem