A convenient method for synthesis of 1,1-diisopropoxycyclohexane was written by Gao, Jinliang;Li, Xianggao;Hu, Cong;Wang, Shirong;Feng, Yaqing. And the article was included in Jingxi Huagong in 2007.Application In Synthesis of 1,1-Diisopropoxycyclohexane This article mentions the following:
A method for the synthesis of the title compound [i.e., cyclohexanone diisopropyl ketal, 1,1-bis(1-methylethoxy)cyclohexane] is reported here. A one-pot reaction of cyclohexanone with tri-Me orthoformate using p-toluenesulfonic acid as catalyst in isopropanol provided 1,1-dimethoxycyclohexane. This compound (without separation) reacted further with isopropanol to form the title compound by distilling off the low-boiling product. Structure of the title compound was characterized by elementary anal., 1HNMR and IR. The optimized process conditions and results were n(cyclohexanone) : n(tri-Me orthoformate) : n(isopropanol) : n(p-toluenesulfonic acid) = 1:1.1:4:0.007, number of theor. plates 5, reaction time 15 h, yield 61.5% and GC content 96.4% (area normalization method). In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Application In Synthesis of 1,1-Diisopropoxycyclohexane).
1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application In Synthesis of 1,1-Diisopropoxycyclohexane
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem