A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist was written by Heasley, Brian H.;Jarosz, Renata;Carter, Karen M.;Jenny Van, S.;Lynch, Kevin R.;Macdonald, Timothy L.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.Product Details of 63071-12-5 This article mentions the following:
A recently reported dual LPA1/LPA3 receptor antagonist (1) has been modified to modulate the basicity, sterics, and dipole moment of the 2-pyridyl moiety. Addnl., the implications of installing nonhydrolyzable phosphate head group isosteres with regard to antagonist potency and selectivity at LPA receptors is described. This study has resulted in the development of the first nonhydrolyzable and presumably phosphatase-resistant LPA3-selective antagonist reported to date. In the experiment, the researchers used many compounds, for example, (6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5Product Details of 63071-12-5).
(6-Methoxypyridin-2-yl)methanol (cas: 63071-12-5) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Product Details of 63071-12-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem