Tag: 200-300

Semple, Graeme; Santora, Vincent J.; Smith, Jeffrey M.; Covel, Jonathan A.; Hayashi, Rena; Gallardo, Charlemagne; Ibarra, Jason B.; Schultz, Jeffrey A.; Park, Douglas M.; Estrada, Scott A.; Hofilena, Brian J.; Smith, Brian M.; Ren, Albert; Suarez, Marissa; Frazer, John; Edwards, Jeffrey E.; Hart, Ryan; Hauser, Erin K.; Lorea, Jodie; Grottick, Andrew J. published an article in 2012, the title of the article was Identification of biaryl sulfone derivatives as antagonists of the histamine H3 receptor: Discovery of (R)-1-(2-(4′-(3-methoxypropylsulfonyl)biphenyl-4-yl)ethyl)-2-methylpyrrolidine (APD916).Application In Synthesis of Benzyl(4-bromophenyl)sulfane And the article contains the following content:

The design of a new clin. candidate histamine-H3 receptor antagonist for the potential treatment of excessive daytime sleepiness (EDS) is described. Phenethyl-R-2-methylpyrrolidine containing biphenylsulfonamide compounds were modified by replacement of the sulfonamide linkage with a sulfone. One compound from this series, APD916 (I) increased wakefulness in rodents as measured by polysomnog. with a duration of effect consistent with its pharmacokinetic properties. The identification of a suitable salt form of I allowed it to be selected for further development. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Application In Synthesis of Benzyl(4-bromophenyl)sulfane

The Article related to biaryl sulfone derivative preparation histamine h3 antagonist sar, apd916 h3 antagonist wakefulness, Pharmacology: Structure-Activity and other aspects.Application In Synthesis of Benzyl(4-bromophenyl)sulfane

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On April 22, 2010, Hamada, Maiko; Nakamura, Mitsuharu; Kiuchi, Masatoshi; Marukawa, Kaoru; Tomatsu, Ayumi; Shimano, Kyoko; Sato, Noriko; Sugahara, Kunio; Asayama, Mahoko; Takagi, Kan; Adachi, Kunitomo published an article.Recommanded Product: Benzyl(4-bromophenyl)sulfane The title of the article was Removal of Sphingosine 1-Phosphate Receptor-3 (S1P3) Agonism is Essential, But Inadequate to Obtain Immunomodulating 2-Aminopropane-1,3-diol S1P1 Agonists with Reduced Effect on Heart Rate. And the article contained the following:

A series of 2-substituted 2-aminopropane-1,3-diols having a biphenyl moiety and their phosphate esters were synthesized to obtain sphingosine 1-phosphate receptor-1 (S1P1) receptor agonists with potent immunomodulatory activity accompanied by little or no effect on heart rate. Many of the synthesized compounds sufficiently decreased the number of peripheral blood lymphocytes. Some of the phosphates had potent agonism at S1P1 but no agonism at S1P3, which had been reported to be a receptor responsible for heart rate reduction Although high S1P1/S1P3 selectivity was considered to be favorable to reduce the effect on heart rate, almost all the phosphates showed a remarkable heart rate lowering effect in vivo. The results suggest that other factors in addition to S1P3 agonism should be responsible for the heart rate reduction caused by S1P1 agonists. Only 2-amino-2-[2-[2′-fluoro-4′-(4-methylphenylthio)biphenyl-4-yl]ethyl]propane-1,3-diol (6d) was identified as a desired S1P1 receptor agonist having both the immunomodulatory activity and an attenuated effect on heart rate by a unique screening flow using in vivo evaluating systems primarily. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Recommanded Product: Benzyl(4-bromophenyl)sulfane

The Article related to multiple sclerosis immunomodulators agonists decrease heart rate, Pharmacology: Structure-Activity and other aspects.Recommanded Product: Benzyl(4-bromophenyl)sulfane

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On May 4, 2006, Ghosh, Shomir; Elder, Amy; Guo, Jianping; Mani, Ukti; Patane, Michael; Carson, Kenneth; Ye, Qing; Bennett, Robert; Chi, Shannon; Jenkins, Tracy; Guan, Bing; Kolbeck, Roland; Smith, Sean; Zhang, Cheng; LaRosa, Gregory; Jaffee, Bruce; Yang, Hua; Eddy, Priya; Lu, Chuang; Uttamsingh, Vinita; Horlick, Robert; Harriman, Geraldine; Flynn, Daniel published an article.Reference of 3-(2-Methoxyphenoxy)benzaldehyde The title of the article was Design, Synthesis, and Progress toward Optimization of Potent Small Molecule Antagonists of CC Chemokine Receptor 8 (CCR8). And the article contained the following:

Activation of CCR8 by its ligand CCL1 may play an important role in diseases such as asthma, multiple sclerosis, and cancer. The study of small mol. CCR8 antagonists will help establish the validation of these hypotheses. We report the design, synthesis, and progress toward optimization of potent small mol. CCR8 antagonists identified from a high-throughput screen. These analogs exhibit good potency in binding and chemotaxis assays, show good selectivity vs. the hERG channel, and have good eADME (early absorption, distribution, metabolism, and excretion) profiles. The experimental process involved the reaction of 3-(2-Methoxyphenoxy)benzaldehyde(cas: 66855-92-3).Reference of 3-(2-Methoxyphenoxy)benzaldehyde

The Article related to ccr8 antagonist preparation sar herg channel, Pharmacology: Structure-Activity and other aspects.Reference of 3-(2-Methoxyphenoxy)benzaldehyde

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On June 30, 2020, Zhang, Min; Zhang, Hai; Luo, Kunyuan; Zhao, Yang published a patent.Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene The title of the patent was Composite adsorbent and preparation method thereof. And the patent contained the following:

The composite adsorbent of the present invention comprises a mixture of (A) component and (B) component, wherein the (A) component and (B) component are surface-modified. Said (A) component is silicate, and said (B) component is at least one metal oxide selected from alkali metal oxides and alk. earth metal oxides. The preparation method of the composite adsorbent comprises the steps of (1) mixing components (A) and (B), and (2) subjecting the mixture obtained in the step (1) to surface modification. The composite adsorbent provided by the invention can remarkably remove or reduce the plasticizer in the grease. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

The Article related to composite adsorbent silicate metal oxide grease, Placeholder for records without volume info and other aspects.Name: 1-((2-Ethylhexyl)oxy)-4-methoxybenzene

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On September 7, 2012, Sakai, Norio; Miyazaki, Takahiro; Sakamoto, Tomohiro; Yatsuda, Takuma; Moriya, Toshimitsu; Ikeda, Reiko; Konakahara, Takeo published an article.SDS of cas: 53136-21-3 The title of the article was Single-step thioetherification by indium-catalyzed reductive coupling of carboxylic acids with thiols. And the article contained the following:

Direct thioetherification from a variety of aromatic carboxylic acids and thiols using a reducing system combined with InBr3 and 1,1,3,3-teramethyldisiloxane (TMDS) in a one-pot procedure is demonstrated. It was also found that a system combined with InI3 and TMDS underwent thioetherification of aliphatic carboxylic acids with thiols. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).SDS of cas: 53136-21-3

The Article related to carboxylic acid thioetherification reductive coupling thiol indium catalyst, Aliphatic Compounds: Alcohols and Thiols and other aspects.SDS of cas: 53136-21-3

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Abdalkareem Jasim, Saade; Mohsen, Ahmed M.; Hussien, Mohamed; Catalan Opulencia, Maria Jade; Majdi, Ali; Urunbaevna Tillaeva, Gulnora; Kadhim, Mustafa M.; Yasin, Ghulam published an article in , the title of the article was Tribromide immobilized on surface of magnetic nanoparticles modified tris(triazine-triamine): A versatile and highly active catalyst for oxidation of sulfides and oxidative coupling of thiols.Name: Benzyl(4-bromophenyl)sulfane And the article contains the following content:

In this article, we show that tribromide heterogenized on the surface of silica-coated magnetic nanoparticles modified with N2,N4,N6-tris(aminomethyl)-1,3,5-triazine-2,4,6-triamine [Fe3O4@SiO2-tris(triazine-triamine)-Br3] is a novel and efficient reusable nanocatalyst for the oxidation of sulfides to sulfoxides and oxidative coupling of thiols to disulfides using hydrogen peroxide as green oxidant. The structure of the as-fabricated Fe3O4@SiO2-tris(triazine-triamine)-Br3 was characterized by a series of spectroscopic techniques including FT-IR spectroscopy, SEM, TEM, EDX, VSM, XRD and TGA techniques. TEM and SEM anal. confirmed that the typical silica shell thickness was assessed to be around 20 nm. Recycling studies revealed that the Fe3O4@SiO2-tris(triazine-triamine)-Br3 could be easily recovered by a simple magnetic separation and recycled at least 6 times without deterioration in catalytic activity. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Name: Benzyl(4-bromophenyl)sulfane

The Article related to magnetic nanoparticle oxidation sulfide oxidative coupling thiol, Placeholder for records without volume info and other aspects.Name: Benzyl(4-bromophenyl)sulfane

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On September 30, 2017, Azizi, Mojtaba; Maleki, Ali; Hakimpoor, Farahman published an article.Product Details of 53136-21-3 The title of the article was Solvent, metal and halogen-free synthesis of sulfoxides by using a recoverable heterogeneous urea-hydrogen peroxide silica-based oxidative catalytic system. And the article contained the following:

An efficient and green protocol was used for the selective oxidation of sulfides to sulfoxides by using silica sulfuric acid (SSA) as a recoverable heterogeneous solid acid catalyst in the presence of urea-hydrogen peroxide (UHP) under toxic transition metal-, solvent- and halogen-free conditions at room temperature The present method offers several noteworthy advantages, such as high product yields, easy work-up, non-toxicity, easy preparation and reusability of the catalyst for at least six runs, which make this procedure the most convenient and attractive with low cost of catalyst and oxidant. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Product Details of 53136-21-3

The Article related to sulfoxide preparation urea hydrogen peroxide silica oxidative catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 53136-21-3

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On July 17, 2020, Liu, Chenjing; Chen, Dengfeng; Fu, Yuanyuan; Wang, Fei; Luo, Jinyue; Huang, Shenlin published an article.Product Details of 53136-21-3 The title of the article was Sulfoxide Reduction/C(sp3)-S Metathesis Cascade in Ionic Liquid. And the article contained the following:

A sulfoxide reduction/C-S bond metathesis cascade between sulfoxides and alkyl bromides has been developed to access high-value sulfides without the use of any catalysts or bases. In this cascade, classical Kornblum oxidation is employed to reduce sulfoxides with alkyl bromides in ionic liquid This protocol features high functional tolerance, mild conditions, promising scalability, and sustainable solvents. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Product Details of 53136-21-3

The Article related to sulfoxide reduction metathesis cascade ionic liquid alkyl bromide, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 53136-21-3

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On December 31, 2009, Azizi, N.; Amiri, A. Khajeh; Bolourtchian, M.; Saidi, M. R. published an article.Product Details of 53136-21-3 The title of the article was A green and highly efficient alkylation of thiols in water. And the article contained the following:

An environmentally benign and efficient process for the preparation of thioethers was developed by simple and practical reactions of alkyl halides and thiols in H2O in the presence of K2CO3 or Et3N in very high yields. The reaction of aryl, alkyl, aliphatic, and hindered thiols with various alkyl halides gave the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with good to quant. yields. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Product Details of 53136-21-3

The Article related to thiol alkyl halide alkylation water, thioether green preparation, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 53136-21-3

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On September 17, 2020, Ban, Shintaro; Endo, Tomotake; Matsui, Rikako; Morita, Nobuyoshi; Hashimoto, Yoshimitsu; Tanaka, Kosaku III; Tamura, Osamu published an article.Synthetic Route of 157869-15-3 The title of the article was Intramolecular activation of imidate with cationic gold(I) catalyst: A new benzylation reaction of alcohols. And the article contained the following:

Benzylation of alcs. with benzyl (Z)-2,2,2-trifluoro-N-(2-alkynylphenyl)acetimidates I (R1 = nBu, C6H5, 4-CF3C6H4, 4-MeOC6H4; R2 = H, NO2, OMe) in the presence of a cationic gold(I) catalyst was investigated. Reagent I (R1 = C6H5; R2 = OMe) was the most effective, affording benzyl ethers in good yields. This results indicate that these gold(I)-activated imidates are effective leaving groups. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Synthetic Route of 157869-15-3

The Article related to benzyl ether preparation gold catalyst, alc imidate benzylation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 157869-15-3

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