Tag: M.W=100-200

Application of 131713-50-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 131713-50-3, name is 2,2-Dimethoxypropan-1-amine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The precursor 2,2-dimethoxypropylamine can be preparedaccording to the methodology described, for example, in Cui, P.et al., Bioorganic & Medicinal Chemistry Letters, 2006, 16(13),3401-3405. A previously prepared solution of 2,2- dimethoxypropylamine in anhydrous tetrahydrofuran (5.4 g of the amine (41.16 mmol) in 50 mL of the organic solvent) was slowlyadded at a temperature of -5C to the solution obtained according to the methodology described in Comparative Example 6. Once the addition ended, the temperature of the obtained mixture was increased to about 20C, and it was kept under stirring for 16 hours at a temperature of about 20C.Once it no longer had to be kept under the aforementioned conditions, 50 mL of an 8% aqueous NaHCO3 solution and 50 mL of 2-methyltetrahydrofuran were added. The resulting mixture was kept under stirring for about 5 minutes and the resulting organic phase containing (3S)-3-[7-bromo-2-(2,2-dimethoxypropylamino)-5-pyridin-2-yl-3H-benzo[e] [l,4]diazepin-3- yl]propionic acid methyl ester was subsequently separated. The organic solvent was vacuum-distilled, and 50 mL of acetone were added to the resulting residue. The obtained mixture was heated at the reflux temperature and then slowly cooled to about 20C.The resulting solid was filtered and oven-dried, finally obtaining 5.2 g (75.7% from 3-[(3S)-7-bromo-2-oxo-5-(pyridin-2- yl)-2,3-dihydro-1H-[1,4]-benzodiazepin-3-yl] propionic acid methyl ester of formula (D), with a purity of 98.5% by means of UPLC) of (3S)-3-[7-bromo-2-(2,2-dimethoxypropylamino)-5-pyridin- 2-yl-3H-benzo[e] [1,4]diazepin-3-yl]propionic acid methyl ester.Figure 6 shows the 1H-NMR spectrum. 1H-NMR (CDC13, 400 MHz)6 (ppm) : 8.65 (1H, d) , 7.79 (2H, m) , 7.48 (1H, dd) , 7.35 (2H, m)7.10 (1H, d) , 5.18 (1H, m) , 3.70 (3H, s) , 3.64 (1H, dd) , 3.45(1H, dd), 3.31 (1H, dd), 3.22 (3H, s), 3.21 (3H, s), 2.77(1H,m) , 2.65-2.37 (3H, m) , 1.72 (1H, s) , 1.29 (3H, s)Figure 7 shows the 13C-NMR spectrum. 13C-NMR (CDC13, 400MHz) 6(ppm): 173.31, 167.89, 156.77, 154.75, 149.57, 149.16,136.57, 133.78, 133.07, 128.51, 127.10, 124.44, 124.24, 112.33,100.14, 60.24, 51.80, 48.65, 48.62, 45.72, 30.84, 26.23, 20.57.

The synthetic route of 2,2-Dimethoxypropan-1-amine has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 15799-79-8 as follows. HPLC of Formula: C9H13NO

General procedure: (Scheme 1: cat.= H3PW12O40, oxidant= air, solvent= DMSO/CH3CO2H). A 50mL flask equipped with a magnetic stirrer was charged with 1,4-naphthoquinone (1) (20mmol; 3.16g), aromatic compounds (10mmol), 15mL of CH3COOH and H3PW12O40 (288mg; 1mol%). The flask was heated at 100C for 24h. After that time, the flask was cooled down to room temperature and 15mL of chloroform was added. The solution was washed with 20mL of brine. The organic phase was separated and dried by MgSO4. The solvent was evaporated under reduced pressure and the residue was purified by column chromatography on silica gel, using a gradient hexane/acetone mixture as eluent.

According to the analysis of related databases, 15799-79-8, the application of this compound in the production field has become more and more popular.

Adding a certain compound to certain chemical reactions, such as: 456-55-3, name is (Trifluoromethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 456-55-3, Formula: C7H5F3O

EXAMPLE 1 4-Trifluoromethoxybenzaldehyde (A) with (2-trifluoromethoxybenzaldehyde (B)) 0.5 liter (25 Mol) of HF is added with brine cooling (5 C.) to 162 g (1 mol) of trifluoromethoxybenzene and 140 g (1 mol) of urotropine in a V4 A stainless steel stirred autoclave. The apparatus is sealed pressuretight and heated to 80 C. for 5 hours. A pressure of 6 to 7 bar becomes established. When the reaction has ended, the crude reaction mixture, which is cooled down to 25 C., is stirred into 1 liter of water and stirred therein at 5 C. for 15 minutes, the organic content is then isolated, and the aqueous phase is extracted with methylene chloride. Crude distillation of the washed organic phases gives 135 g of product (boiling point: 72-74 C./8 mbar).

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Reference of 53903-49-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 53903-49-4, name is 4-Methoxy-2-(trifluoromethyl)aniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

(c) 4-Methoxy-6-(methylthiomethyl)-2-(alpha,alpha,alpha-trifluoromethyl)aniline was prepared by substituting 4-methoxy-2-(alpha,alpha,alpha-trifluoromethyl)aniline as follows: In a 250 ml three-necked flask equipped with an overhead stirrer was placed 20.12 g (0.105 mol) of 4-methoxy-2-(alpha,alpha,alpha-trifluoromethyl)aniline in 100 ml of methylene chloride. To the solution was then added 15.63 g (0.117 mol) of N-chlorosuccinimide was added with vigorous stirring. After cooling to 0 C. under a nitrogen atmosphere, a solution of 9.2 ml (8.02 g, 0.129 mol) dimethylsulfide in 40 ml of methylene chloride was then added over a one hour period while maintaining the temperature below 5 C. The reaction mixture became very thick. The ice bath was removed and after stirring at room temperature for one hour, 200 ml of ice cold 5% aqueous sodium hydroxide solution was added. The methylene chloride layer was separated, dried over anhydrous potassium carbonate, filtered and the solvent removed under reduced pressure. To the residue was then added 60 ml of 1,2-dichloroethane and 1.00 g (10 mmol) of succinimide. After refluxing for twelve hours under a nitrogen atmosphere, the reaction mixture was cooled, washed twice with 100 ml of 5% sodium hydroxide solution, dried with magnesium sulfate, filtered and concentrated under reduced pressure to afford 24.9 g of a black oil. This was distilled under reduced pressure to afford 16.5 g (63% yield) of the desired product as a clear, colorless liquid (Bp 106-110 at 0.35 mm Hg) of 95% purity as assayed by gas chromatography; 1 H NMR analysis indicated: (delta, CDCl3) 6.94 (d, J=1.8 Hz, 1H), 6.78 (d, J=1.8 Hz, 1H), 4.32 (br s, 2H, NHz), 3.54 (s, 3H), 3.51 (s, 2H) and 1.82 (s, 3H). Mass spectrum analysis indicated: (m/e) 251 (M+), 204 (100%) and 181.

The synthetic route of 4-Methoxy-2-(trifluoromethyl)aniline has been constantly updated, and we look forward to future research findings.

Application of 126940-10-1, A common heterocyclic compound, 126940-10-1, name is 1-Fluoro-3-(methoxymethoxy)benzene, molecular formula is C8H9FO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a flame dried 100mL flask were added 1,3-disustituted benzene (3.0mmol), TMEDA (1.1equiv, 3.3mmol), DIPA (5%equiv, 0.16mmol), and THF (10.0mL). The solution was cooled to -78C for 10min and then n-BuLi (1.1equiv, 3.3mmol) was added dropwise. The mixture was kept at this temperature for 1h; DMF (1.5equiv, 4.5mmol) was added and the mixture was further stirred for another half an hour at -78C. The mixture was allowed to warm up to room temperature and quenched by the addition of saturated NH4Cl-H2O solution (5mL); extracted three times with ethyl acetate (10mL×3). The combined organic layers were dried over anhydrous MgSO4, filtered, and concentrated in vacuo. The regioselectivity of the crude product was ascertained by 19F NMR (for fluorinated products) or by GC/MS (for nonfluorinated ones) and then subjected to flash chromatography to obtain the desired products which were characterized by 1H NMR, 19F NMR, and 13C NMR spectral data and GC-MS analyses.

The synthetic route of 126940-10-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 15799-79-8, The chemical industry reduces the impact on the environment during synthesis 15799-79-8, name is 3-Methoxy-N,N-dimethylaniline, I believe this compound will play a more active role in future production and life.

[0109] (R)-3-(4-Nitro-phenyl)-3-(4-dimethylamino-2-methoxy-phenyl)-propionaldehyde (Table 1, entry 9): To a 2-dram vial equipped with a magnetic stir bar was added (2S,5S)-5-benzyl-2-tert-butyl-3-methylimidazolidin-4-one (24.6 mg, 0.100 mmol, 0.100 equiv), N,N-dimethyl-m-anisidine hydrochloride (18.8 mg, 0.100 mmol, 0.100 equiv), CH2Cl2 (1.00 ml), and N,N-dimethyl-m-anisidine (425 uL, 2.90 mmol, 2.90 equiv). The solution was cooled to -10o C. before p-nitro-cinnamaldehyde (177 mg, 1.00 mmol, 1.00 equiv) was added as a solid. After 48 h, the reaction mixture was subjected directly to silica gel chromatography. Gradient elution with 10-50% EtOAc in hexanes followed by concentration in vacuo afforded the product as a bright orange oil in 87% yield (285 mg, 0.867 mmol); 92% ee. IR (film) 2938, 2894, 2837, 2726, 1722, 1614, 1516, 1345, 1241, 1120, 1033, 980.1, 858.6, 814.9 cm-1; 1HNMR (300 MHz, CDCl3) ?9.74 (t, J=1.9 Hz, 1H, CHO), 8.12 (td, J=2.2, 9.3 Hz, 2H, ArH), 7.42 (td, J=1.5, 9.3 Hz, 2H, ArH), 6.97 (d, J=8.3 Hz, 1H, ArH), 6.30 (dd, J=2.5, 8.8 Hz, 1H, ArH), 6.24 (d, J=2.2 Hz, 1H, ArH), 4.98 (t, J=7.8 Hz, 1H, ArCH), 3.79 (s, 3H, OCH3), 3.21-3.09 (m, 2H, CH2CO), 2.96 (s, 6H, N(CH3)2); 13C NMR (75 MHz, CDCl3) ?201.2, 157.8, 152.3, 151.4, 146.5, 128.9, 128.6, 123.8, 118.0, 104.8, 96.4, 55.4, 48.4, 40.8, 38.2. HRMS (CI) exact mass calcd for (C18H20N2O4) requires m/z 328.1423, found m/z 328.1422. [?]D=0.58.1 (c=1.0, CHCl3). [0110] The enantiomeric ratio of the product was determnined by HPLC analysis of the corresponding alcohol (obtained by NaBH4 reduction of the aldehyde) using a Chiracel AD and AD guard column (10% ethanol/hexanes, 1 mL/min); R isomer tr=25.6 min, S isomer tr=29.5 min.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Methoxy-N,N-dimethylaniline, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 2186-92-7, name is P-anisaldehyde dimethyl acetal, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2186-92-7, HPLC of Formula: C10H14O3

7-Anisaldehyde dimethylacetal (50 mL, 294 mmol, 1.14 equiv) was added to a suspension of a mixture of methyl a-D-glucopyranoside (50 g, 257 mmol) and D- camphorsulfonic acid (1.79 g, 7.72 mmol, 0.03 equiv) in DMF (250 mL). The reaction mixture was stirred at 60 C for 21 h. After cooling to rt, the solution was concentrated under reduced pressure. A saturated sodium bicarbonate aqueous solution (500 mL) was added to the residue and the resulting mixture was stirred for 1 h. The precipitate was filtered and washed with cold aqueous saturated sodium bicarbonate solution (500 mL) to provide methyl 4,6-O-(4-methoxy)benzylidene-a-D-galactopyranoside (78.5 g, 98%) as a colorless solid, mp: 192-194 C; 1H NMR (CD3OD, 600 MHz) delta = 7.40 (d, 2H, J = 8.4 Hz, CH of Ar), 6.88 (d, 2H, J = 8.4 Hz, CH of Ar), 5.51 (s, IH, ArCH), 4.71 (d, IH, J = 3.8 Hz, H- l), 4.18 (dd, IH, J = 8.1 Hz, 3.3 Hz, H-6?), 3.81-3.78 (m, IH, H-4), 3.78 (s, 3H, OCH3 of An), 3.74-3.68 (m, 2H, H-3, H-6P), 3.50 (dd, IH, J = 9.3 Hz, 3.8 Hz, H-2), 3.43-3.40 (m, IH, H-5), 3.42 (s, 3H, OCH3); 13C NMR (CD3OD, 125 MHz) delta = 161.6, 131.5, 128.8, 114.3, 103.0, 102.0, 82.9, 74.1, 72.0, 70.0, 63.9, 55.8, 55.7; HRMS (ESI) Calcd for Ci5H2107 [M+H]+: 313.1287

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Reference of 36397-23-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36397-23-6, name is 3-(4-Methoxyphenyl)propan-1-amine, This compound has unique chemical properties. The synthetic route is as follows.

3-(4-Hydroxyphenyl)propylamine hydrobromide (14). Compound 14 was synthesised according to procedure B from 13 (2.5 g, 0.015 mol) in 75% yield as a light brown solid. 1H NMR (300 MHz, DMSO-d6) delta1.80 (m, 2H), 2.53 (m, 2H), 2.78 (m, 2H), 6.70 (d, 2H), 7.02 (d, 2H), 7.80 (br s, 4H).

The chemical industry reduces the impact on the environment during synthesis 3-(4-Methoxyphenyl)propan-1-amine. I believe this compound will play a more active role in future production and life.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 50868-72-9, name is 5-Methoxy-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., SDS of cas: 50868-72-9

3-Fluoro-4-methyl-phenyl chloroformate A mixture of 5-methoxy-2-methyl aniline (5.0 g; 36 mmol), HCl (7.6 mL of a 12 M solution; 91 mmol) and H2O (11 mL) was heated at 60 C. for 15 min until complete dissolution had occurred. The reaction was cooled to 0 C. and an aqueous solution of NaNO2 (2.5 g; 36 mmol) was added dropwise (internal temperature <=7 C.). The reaction was stirred at 0 C. for 30 min and a 0 C. solution of HBF4 (5.3 mL of a 48% solution; 40 mmol) was added cautiously. The reaction was stirred at 0 C. for 20 min, and the resultant brown solid was filtered, washed with ice water (3*10 mL) and H2O (2*10 mL). The solid was dried under high vacuum for 20 h, then heated (heat gun) until evolution of BF3 (white fumes) had ceased. The resulting brown oil was partitioned between EtOAc and H2O. The organic phase was dried (Na2SO4), concentrated in vacuo and distilled by Kugelrohr to give 3-fluoro-4-methyl anisole (1.6 g; 31%) as a colorless oil. According to the analysis of related databases, 50868-72-9, the application of this compound in the production field has become more and more popular.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2186-92-7, name is P-anisaldehyde dimethyl acetal, A new synthetic method of this compound is introduced below., Quality Control of P-anisaldehyde dimethyl acetal

Step a); Methyl 4,6-0-(4-methoxybenzylidene)-alpha-D-glucopyranoside(4); A solution of methyl alpha-D-glucopyranoside (10 g, 51.5 mmol) in dimethylformamide (DMF, 50 ml) was added with a catalytic amount of camphorsulfonic acid (CSA) and anysaldehyde dimethylacetal (ADMA, 10 ml, 51.5 mmol) and the mixture was kept under magnetic stirring and low vacuum to remove the methanol formed during the condensation reaction. After 40 min the solvent was evaporated off. The residue was added with a NaHCO3 saturated solution and the resulting diphasic mixture was kept under vigorous stirring for one hour. The resulting precipitate was filtered and washed with an ice-cold bicarbonate solution (100 ml). The residue was triturated in hexane to afford compound 4 as a white solid (15 g, 94%). 4: Rf = 0,31 (EtOAc/MeOH/H2O 7:2:1).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.