New downstream synthetic route of (Trifluoromethoxy)benzene

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Adding a certain compound to certain chemical reactions, such as: 456-55-3, name is (Trifluoromethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 456-55-3, Formula: C7H5F3O

EXAMPLE 1 4-Trifluoromethoxybenzaldehyde (A) with (2-trifluoromethoxybenzaldehyde (B)) 0.5 liter (25 Mol) of HF is added with brine cooling (5 C.) to 162 g (1 mol) of trifluoromethoxybenzene and 140 g (1 mol) of urotropine in a V4 A stainless steel stirred autoclave. The apparatus is sealed pressuretight and heated to 80 C. for 5 hours. A pressure of 6 to 7 bar becomes established. When the reaction has ended, the crude reaction mixture, which is cooled down to 25 C., is stirred into 1 liter of water and stirred therein at 5 C. for 15 minutes, the organic content is then isolated, and the aqueous phase is extracted with methylene chloride. Crude distillation of the washed organic phases gives 135 g of product (boiling point: 72-74 C./8 mbar).

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