Tag: M.W=100-200

Synthetic Route of 14593-43-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 14593-43-2 name is ((Allyloxy)methyl)benzene, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: (2) An ozone-oxygen mixture was bubbled through a solution of 10.00 mmol of ethers Ia or Ib in50 mL of MeOH at -78C until blue color appeared.The reaction mixture was purged with argon, 3.88 g(35.00 mmol) of NH2C(O)NHNH2 HCl. HCl was added at -50C. The mixture was stirred at ambient temperature for 24 h. The reaction mixture was evaporated, the residue was dissolved in 100 mL of CHCl3, washed with 2 (to pH ? 7), and dried with Na2SO4. After evaporation, ether I produced 1.86 g of a mixture of compounds II and IV in 40 : 60 ratio(according to GLC and NMR), column chromatography (Si2, PE, PE : MTBE = 5 : 1, 4 : 1) afforded0.74 g (42%) of ester IIa and 1.09 g (56%) of acetal IV.After evaporation, ether Ib produced 1.64 g of a mixture of compounds IIb and IVb in 25 : 75 ratio (according to GLC and NMR data), column chromatography (Si2, PE, PE : MTBE = 5 : 1, 4 : 1) gave 0.40 g (24%)of ester IIb and 1.15 g (63%) of acetal IVb.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, ((Allyloxy)methyl)benzene, and friends who are interested can also refer to it.

Synthetic Route of 10075-63-5,Some common heterocyclic compound, 10075-63-5, name is 1,5-Dimethoxynaphthalene, molecular formula is C12H12O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Under nitrogen, 300 mg (1.1 mmol) of 1,3,4-tri-O-acetyl-2,6-dideoxy-L-rhamnose and 620 mg (3.3 mmol) of 1,5-dimethoxynaphthalene After mixing with 30 mL of 1,2-dichloroethane, 27.94 mg (0.11 mmol) of I2 and 5.27 muL (0.033 mmol) of Et3SiH catalyst were added at a temperature of 25 C, and the TLC plate (PE: EA = 6: 1) to monitor the reaction, the reaction solution was isolated and purified to obtain 40.2 mg of the product as 3,4-di-O-acetyl-2,6-dideoxy-L-squirrel Sugar 1,5-dimethoxynaphthalene-beta-C-glycoside in a yield of 91%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1,5-Dimethoxynaphthalene, its application will become more common.

2039-54-5, name is 2-(3-Methoxyphenyl)ethanamine hydrochloride, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C9H14ClNO

59. Modification on R4; To make R4 deletion, the following synthetic route was developed as shown in the Scheme.

The synthetic route of 2039-54-5 has been constantly updated, and we look forward to future research findings.

Electric Literature of 151414-47-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 151414-47-0, name is 2,6-Difluoro-4-methoxyaniline, This compound has unique chemical properties. The synthetic route is as follows.

Step B: Preparation of 4-(2-Chloro-4-fluorophenyl)-Lambda/-(2,6-difluoro-4-methoxyphenyl)-l,3-dimethyl-lH-pyrazol-5-amine5-Bromo-4-(2-chloro-4-fluorophenyl)-l,3-dimethyl-lH-pyrazole (i.e. the product ofStep A) (0.20 g, 0.66 mmol), palladium(II) acetate (15 mg, 0.066 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (76 mg, 0.13 mmol) and powdered potassium carbonate (1.8 g, 13 mmol) were combined in anhydrous 1,4-dioxane (3 mL), and the mixture was sparged with a subsurface stream of N2 gas for 10 min. 2,6-Difluoro-4-methoxyaniline (0.22 g, 1.3 mmol) was added in one portion, and the reaction mixture was heated at reflux for 22 h. The reaction mixture was filtered through Celite diatomaceous filter aid, and the filter pad was washed with ethyl acetate (20 mL). The filtrate was washed with water (10 mL) and brine (10 mL), dried over MgSOphi and concentrated to leave a semisolid residue. This residue was purified by column chromatography through 5 g of silica gel eluted with a gradient of hexanes/ethyl acetate (20:1 to 1 :3) to give the title compound, a compound of the present invention, as a light-brown solid (48 mg). 1H NMR delta 7.0-7.1 (m, 2H), 6.85 (m, IH), 6.26 (m, 2H), 4.84 (br s, IH), 3.78 (s, 3H), 3.66(s, 3H), 2.08 (s 3H). MS: 382 amu.

The chemical industry reduces the impact on the environment during synthesis 2,6-Difluoro-4-methoxyaniline. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 658-89-9, name is 4-(Trifluoromethoxy)benzene-1,2-diamine, A new synthetic method of this compound is introduced below., Formula: C7H7F3N2O

[0373] Compounds 41 and 100: To a mixture of Comp-41a and Comp-lOOa mixture (0.3 g, 1.31 mmol) and Comp-3b (0.29 g, 1.31 mmol) was added i-BuOk (1 mL, 1M in THF) and the reaction mixture was heated at 50 C for 16 h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was diluted with w?ater and extracted with EtOAc (50 mL X 2). The organic layer was washed with water, brine, separated, dried over anhydrous Na2SO4 and concentrated under reduced pressure. The crude obtained was purified by prep HPLC purification to afford a mixture of regioisomers (E)-2-(2-(2,5- dimethyl-l-(l-methylpiperidin-4-yl)-lH-pyrrol-3-yl)vinyl)-7-(trifluoromethoxy)quinoxaline and (E)-2-(2-(2,5-dimethyl-l-(l-methylpiperidin-4-yl)-1H-pyrrol-3-yl)vinyl)-6- (0655) (trifluoromethoxy)quinoxaline (41 and 100, respectively; 0.09 g, 17%) as a yellow solid. (0656) [0374] HPLC purity : 98.19% (0657) [0375] MS (ESI) m/e [M+H]+/Rt/%: 431.20/1.69/97.8% (0658) [0376] 1H NMR (400 MHz, DMSO-d6, 2: l mixture of isomers) delta 1.73 (d, J=l 1.25 Hz, 2H), 2.01 – 2.11 (m, 2H), 2.14-2.17 (m, 2H), 2.23 (s, 3H), 2.29 (s, 3H), 2.44 (s, 3H), 2.91 (d, J=10.27 Hz, 2H), 3.92 – 4.02 (m, 1H), 6.24 (s, 1H), 6.85 (d, J=15.65 Hz, 1H), 7.62 – 7.78 (m, 1H), 7.85 (s, 1H), 7.91 – 7.98 (m, 1H), 8.04 – 8.13 (m, 1H), 9.24 & 9.28 (s, 0.56H & 0.34H).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16728-64-6, name is 3-(Benzyloxy)propan-1-amine, A new synthetic method of this compound is introduced below., Quality Control of 3-(Benzyloxy)propan-1-amine

a) 4-[N-(3-Benzyloxypropyl)aminomethyl]-2′-cyanobiphenyl A solution of 6.0 g (22 mmol) of 4-bromomethyl-2′-cyanobiphenyl, 5.8 g (35 mmol) of 3-benzyloxypropylamine and 3.6 g of triethylamine in 50 ml of 1,4-dioxane is heated to boiling under reflux for 18 hours.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Adding a certain compound to certain chemical reactions, such as: 1077-01-6, name is 1-Fluoro-3-(trifluoromethoxy)benzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1077-01-6, Recommanded Product: 1-Fluoro-3-(trifluoromethoxy)benzene

To a 100 mL round-bottomed flask were added concentrated H2SO4 (25 mL), fuming HNO3 (25 mL), and 1-fluoro-3-(trifluoromethoxy)benzene (9.0 g, 50 mmol) at -10 C. in sequence. The mixture was stirred at rt for 30 min then poured onto ice and extracted with EtOAc (3*20 mL). The combined organic layers were washed with saturated aqueous NaHCO3 solution (30 mL), brine (30 mL), dried over anhydrous Na2SO4, concentrated to dryness, and purified by FCC to give the title compound as a pale-yellow oil (0.50 g). 1H NMR (300 MHz, CDCl3): delta 8.21-8.14 (m, 1H), 7.21-7.12 (m, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Fluoro-3-(trifluoromethoxy)benzene, other downstream synthetic routes, hurry up and to see.

Related Products of 126-38-5,Some common heterocyclic compound, 126-38-5, name is 1-Bromo-2,2-dimethoxypropane, molecular formula is C5H11BrO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

EXAMPLE 213 1-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]-2-propanone hydrochloride A mixture of 4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidine (7.45 g, 33.4 mmol), K2 CO3 (5.5 g) and bromo-2,2-dimethoxypropane (6.84 g, 37.6 mmol) in acetonitrile (200 ml) was heated and stirred at reflux for 4 hours. An additional charge of bromo-2,2-dimethoxypropane (5.1 g, 28 mmol) was added and the mixture was refluxed overnight. After being cooled to room temperature, the mixture was filtered, and the solvent was removed on a rotary evaporator. The residue was purified by flash chromatography over a silica gel column (SiO2, 100 g; eluted with dichloromethane, DCM, and 1% CH3 OH in DCM). The oil product thus obtained weighed 2.2 g (24%). The oil product was dissolved into ethanol (10 ml) then was treated with HCl in ether solution (1M, 9 ml) at room temperature. The crystals were collected, 2.08 g, m.p.=220-223 C. dec. Analysis: Calculated for C15 H17 FN2 O2.HCl: 57.60% C 5.80% H 8.96% N Found: 57.49% C 5.97% H 8.67% N

The synthetic route of 126-38-5 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41365-75-7, name is 1-Amino-3,3-diethoxypropane, A new synthetic method of this compound is introduced below., Product Details of 41365-75-7

f) Preparation of intermediate (10)H To a stirred solution of intermediate (9) (287 mmol) in CHC13 (2000 ml) was added 3,3-diethoxy-l-propanamine (474 mmol) at 0C in portions. After the addition, the reaction mixture was stirred at 0C for 1 hour and then at 15C for 2 hours. Thin Layer Chromatography (petroleum ether/ethyl acetate= 5/1) showed that the reaction was completed. The reaction mixture was washed by saturated Na2S03 aqueous (four times with 600 ml) and then saturated NaHC03 aqueous was added until pH = 7. The aqueous layer was extracted by CH2C12 (500 ml). The combined organic phases were washed with brine (800 ml), dried over Na2S04 and concentrated to give the crude product. The crude product was washed by tert-butyl methylether (three times 500 ml) to give 87 g of intermediate (10) (mp. 100.8 – 103.8C).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

36865-41-5, name is 1-Bromo-3-methoxypropane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 36865-41-5

To a solution of the compound of Reference Example 50 (114.3 mg, 0.182 mmol) in DMF (2 mL), potassium carbonate (50.3 mg, 0.364 mmol) and 1-bromo-3-methoxypropane (41.8 mg, 0.273 mmol) were added, and the mixture was stirred at 50C for 1 hour. A saturated aqueous solution of ammonium chloride was added to the reaction mixture, followed by extraction with ethyl acetate. The organic layer was washed with a saturated aqueous solution of ammonium chloride twice and with a saturated saline solution once, then dried over sodium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain the title compound (121.2 mg, 95%). MS (ESI+) 700 (M+1, 68%)

The synthetic route of 36865-41-5 has been constantly updated, and we look forward to future research findings.