Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22236-10-8, name is 4-(Difluoromethoxy)aniline, A new synthetic method of this compound is introduced below., Computed Properties of C7H7F2NO

General procedure: N-substituted benzylidene pyrrolidine dione (0.5 mol),0.6 mmol TBTU, and 0.6 mmol EDCI were dissolved in 2mL DCM and 0.75 mmol DIEA mixture solution and stirred for 30 min. Next, 0.5 mol of amine or methylamino acid in DCM (8 mL) solution was slowly added to the solution and stirred at room temperature for 4-10 h with the TLC monitoring reaction. After the reaction was complete, the resultant solution was washed with dilute hydrochloricacid and saturated sodium bicarbonate solution, then dried with anhydrous sodium sulfate, followed by column chromatography separation. The target product was obtained by crystallization.The yield ranged from 72 to 90%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C9H13NO2

(1) 2,3-Dimethoxybenzylamine (33.4 mg, 0.2 mmol), 3,4-dimethoxyphenylsulfide ylide (102.5 mg, 0.4 mmol), in a clean reactor,Dichloro(pentamethylcyclopentadienyl) ruthenium (III) dimer (6.18Mg, 0.01 mmol), silver acetate (6.67 mg, 0.04 mmol) and water (2 mL),Stir in a 100 C oil bath for 24 h.(2) After the reaction is completed, dichloromethane is added for extraction, and a dichloromethane layer is collected.The solvent was removed under reduced pressure.The residue was purified by silica gel column chromatography to give a yellow solid.The yield was 37%.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 4393-09-3.

Reference of 82830-49-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 82830-49-7, name is 2-Fluoro-1,4-dimethoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step A: A 3-neck 1-liter flask equipped with a low temperature thermometer, N2 line, and dropping funnel was charged with 1, 4-dimethoxy-2-fluorobenzene (20.42 g, 131 mmol). The solid was dissolved in distilled THE (450 mL) and cooled to an internal temperature of-74DEG C. A 2.5 M solution of n-BuLi in hexane (63 mL, 157 mmol) was subsequently added over 25 min. under N2 via a dropping funnel. The reaction was maintained at-75 DEGC for 30 min. , before adding solid sulfur (5.01 g, 157 mmol) in one portion. Nitrogen sparging of the reaction mixture was begun at this time and continued throughout the reaction. The internal temperature rose to-65 DEG C but quickly recooled to-75 DEG C. The reaction temperature was maintained at-75 DEG C for 30 min. At this time, the excess dry ice in the dry ice/acetone bath was removed and the reaction was allowed to slowly warm to-20 DEG C over 1.5 h. The reaction was quenched with 2 N HC1 with vigorous N2 bubbling until the color of the reaction turned pale yellow.The internal temperature of the reaction rose to 10 DEG C. The reaction was extracted with EtOAc. The organic layer was collected, washed with brine, dried over MgS04, filtered, and concentrated in vacuo. The yellow residue was purified by silica gel chromatography with 20% EtOAc/hexane as the eluant to give the desired product as a light yellow solid. 1H 600MHz NMR (CDC13) ppm (8) : 3.84 (s, 3H), 3.86 (s, 3H), 6.56 (dd, J=1.8 Hz, J=8.9 Hz, 1H), 6.70 (t, 1H).

The synthetic route of 2-Fluoro-1,4-dimethoxybenzene has been constantly updated, and we look forward to future research findings.

78531-29-0, name is 1,3-Dimethoxypropan-2-amine, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 1,3-Dimethoxypropan-2-amine

General procedure: Example 6B (0.018 g, 0.05 mmol) was dissolved in acetonitrile (0.5 ml), and treated with potassium carbonate (0.021 g, 0.15 mmol) and 1 -(2-chloroethyl)pyrrolidine (0.017 g, 0.1 mmol). The reaction mixture was heated via microwave at 180 C for 30 minutes, concentrated in vacuo, and submitted to reverse-phase HPLC (as described in Example 6C) to provide the title compound.

The synthetic route of 78531-29-0 has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 36865-41-5, name is 1-Bromo-3-methoxypropane, molecular formula is C4H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of 1-Bromo-3-methoxypropane

(R)-tert-Butyl 3-(1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (7B) (9.95 mmol, 3.0 g) was added to a 200 mL round-bottomed flask equipped for stirring under nitrogen. DMF (50 mL) was added and the resultant solution was cooled to 0 C. with an ice bath. NaH (60% in mineral oil, 11.95 mmol, 0.478 g) was then added and the subsequent solution was allowed to stir under nitrogen for 0.5 hr. At this time 1-bromo-3-methoxypropane (12.44 mmol, 1.90 g) was added, the ice bath was removed and the reaction solution was allowed to warm to room temperature and stir fort hr. The reaction solution was then poured into ice-water, extracted with ethyl acetate, and washed once with saturated aqueous sodium chloride. The organic layer was collected and subsequently dried with anhydrous Na2SO4 and filtered. This filtrate was collected, concentrated, and dried in-vacuo affording a brown oil. This material was then purified by chromatography on silica gel (3-10% CH3OH in CH2Cl2) to afford (R)-tert-butyl 3-(1-(3-methoxypropyl)-1H-benzo[d]imidazol-2-yl)piperidine-1-carboxylate (7C) as a brown oil (9.63 mmol, 3.6 g, 96% yield). 1H NMR (400 MHz, DMSO-d6) delta ppm 1.55-1.71 (br.s., 1H) 1.79-1.88 (br.s., 1H) 2.04-2.13 (m, 4H) 2.74-2.88 (br.s., 1H) 2.98-3.38 (m, 7H) 4.21-4.39 (m, 3H) 7.22-7.28 (m, 2H) 7.34-7.40 (dd, 1H, 6.57 Hz, 2.02 Hz) 7.72-7.77 (dd, 1H, 6.57 Hz, 2.02 Hz). ESI-MS: m/z 374.4 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 36865-41-5, its application will become more common.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Application In Synthesis of 2-Bromo-1,1-dimethoxyethane

Example 1. (2S)-4-Methyl-2-[(1R, 5S, 7S)-2-oxo-7-(piperidine-1-carbonyl)-6,8-dioxa-3-aza-bicyclo[3.2.1]oct-3-yl]-pentanoic acid methyl ester [compound formula (I), where R1 = -CH(Leu side chain)COOCH3, R2 = H, R3 and R4 = – CH2(CH2)3CH2-] A solution containing L-leucine methyl ester hydrochloride (2.9 g, 16 mmol), 2-bromo-1,1-dimethoxy ethane (1.9 ml, 2.7 g, 16 mmol), NEt3 (6.7 ml, 48 mmol) and a catalytic amount of KI in DMF (190 ml) was stirred at 120 C for 3 days. The reaction mixture was concentrated under reduced pressure, diluted with water and extracted with DCM. The organic layer was then washed with brine, dried over Na2SO4 and evaporated. The crude product was purified by column chromatography (silica gel, EtOAc/P.E. 1:1) to afford compound of formula (III), where R = Leu side chain, as a yellow oil (1.2 g, 32% yield). [alpha]D24 -3.32 (c 1.0, CHCl3); 1H-NMR (CDCl3, 200 MHz): delta 4.38 (t, J = 6 Hz, 1H), 3.65 (s, 3H), 3.30 (s, 3H), 3.29 (s, 3H), 3.24 (t, J = 6 Hz, 1H), 2.68 (dd, J1 = J2 = 6 Hz, 1H), 2.52 (dd, J1 = J2 = 6 Hz, 1H), 1.71-1.55 (m, 2H), 1.44-1.37 (m, 2H), 0.86 (d, J = 4 Hz, 3H), 0.83 (d, J = 4 Hz, 3H); 13C-NMR (CDCl3, 200 MHz): delta 175.9 (s), 103.6 (d), 59.9 (d), 54.0 (q), 53.1 (q), 51.7 (q), 49.3 (t), 42.8 (t), 25.0 (d), 22.8 (q), 22.5 (q); MS m/z 233 (0.5), 202 (7.2), 174 (33), 158 (14), 75 (100); IR (CHCl3) 2915, 1729, 1130, 1065 cm-1; Anal. Calcd for C11H23NO4 (233.30): C, 56.63; H, 9.94; N, 6.00. Found: C, 57.49; H, 9.90; N, 6.24.

The synthetic route of 7252-83-7 has been constantly updated, and we look forward to future research findings.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 36865-41-5, name is 1-Bromo-3-methoxypropane belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: ethers-buliding-blocks

[00449] To a 100 mL single-neck flask were added 4-bromo-1 H-pyrazole (3.0 g, 20 mmol), 1-bromo-3-methoxypropane (3.7 g, 24 mmol), cesium carbonate (13 g, 39.90 mmol) and DMF (30 mL). The mixture was heated to 50 C and stirred overnight. The mixture was cooled to rt and to the mixture was added water (50 mL). The mixture was extracted with DC M (50 mL B 4).The combined organic layers were concentrated in vacuo, and the residue was purified by silica gel column chromatography (PE/EA (VN) = 1/1) to give the title compound as colorless oil (4.3 g, 20 mmol, 96%).MS (ESI, pos.ion) m/z: 219.0 [M÷H].

The synthetic route of 36865-41-5 has been constantly updated, and we look forward to future research findings.

Related Products of 150517-75-2, These common heterocyclic compound, 150517-75-2, name is (2-Fluoro-6-methoxyphenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The 2, 4 – dichloro pyrimidine -5 – formamide (210 mg, 1 . 09 mmol) dissolved in tetrahydrofuran (8 ml) in, respectively adding (2 – fluoro -6 – methoxyphenyl) methylamine (170 mg, 1 . 09 mmol) and diisopropyl serotonin reuptake (423 mg, 3 . 27 mmol), 25 C reaction 2 hours. Add saturated salt water (60 ml), stirring 15 minutes after the filtering, the filter cake washing petroleum ether, to obtain white solid 75 mg, yield 66%.

Statistics shows that (2-Fluoro-6-methoxyphenyl)methanamine is playing an increasingly important role. we look forward to future research findings about 150517-75-2.

Related Products of 29026-74-2,Some common heterocyclic compound, 29026-74-2, name is 2-Isopropoxyaniline, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 2-Hydroxynaphthalene-1-carboxylic acid or 1-hydroxynaphthalene-2-carboxylic acid (5.30 mmol) and appropriate alkoxyaniline (5.30 mmol) were suspended in 30 mL of dry chlorobenzene. Phosphorous trichloride (2.65 mmol) was added dropwise, and reacting mixture was heated in the microwave reactor for 15 min at 130 C using infrared flask-surface control of temperature. Solvent was evaporated in vacuum; residue solid was washed with 2M HCl and crystallized from aqueous ethanol. If necessary, column chromatography was used for further purification (mobile phase DCM:MeOH 19:1).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Isopropoxyaniline, its application will become more common.

Reference of 658-89-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 658-89-9, name is 4-(Trifluoromethoxy)benzene-1,2-diamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2-Aryl-5-trifluoromethoxybenzimidazole. The modified procedure of Bahrami, K. et. al. (Bahrami K., Khodaei M. M., Kavianinia I. Synthesis 2007, p. 547-550) was used. A solution of 2-amino-4-trifluoromethoxyaniline (0.7 g, 0.0036 Mol) in acetonitrile -CH3CN (5 mL) was mixed with aldehyde (0.0037 Mol) in CH3CN (5 mL) at 20 C. and stirred for 5-10 min. Aqueous 30% H2O2 (0.025 Mol) and concentrated 35% aqueous HCl (0.0126 Mol) were added at 20 C. and the mixture was stirred at this temperature for the 2-5 h (the progress of the reaction was monitored by TLC). Precipitate formed was filtered, washed with CH3CN (2×10 mL) and dried.2-Phenyl-5-trifluoromethoxybenzimidazole. Benzaldehyde was used, Ar=C6H5. Yield 0.76 g (71 wt. %). M.p. 208-210 C. 1H NMR (DMSO-d6): 7.31 (d, J=8.5 Hz, 1H), 7.38 (m, 2H), 7.49 (t, J=8.5 Hz, 1H), 7.83 (s, 1H), 7.95 (d, J=8.5 Hz, 1H), 8.57 (d, J=7.0 Hz, 2H). 13C NMR (DMSO-d6): 107.87, 115.26, 116.42, 120.21 (q, J=255.1 Hz), 126.90, 127.98, 128.84, 130.73, 135.91, 138.10, 144.17, 152.51. 19F NMR (DMSO-d6): -57.60. [M+1]+ 279.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethoxy)benzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.