Reference of 658-89-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 658-89-9, name is 4-(Trifluoromethoxy)benzene-1,2-diamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
2-Aryl-5-trifluoromethoxybenzimidazole. The modified procedure of Bahrami, K. et. al. (Bahrami K., Khodaei M. M., Kavianinia I. Synthesis 2007, p. 547-550) was used. A solution of 2-amino-4-trifluoromethoxyaniline (0.7 g, 0.0036 Mol) in acetonitrile -CH3CN (5 mL) was mixed with aldehyde (0.0037 Mol) in CH3CN (5 mL) at 20 C. and stirred for 5-10 min. Aqueous 30% H2O2 (0.025 Mol) and concentrated 35% aqueous HCl (0.0126 Mol) were added at 20 C. and the mixture was stirred at this temperature for the 2-5 h (the progress of the reaction was monitored by TLC). Precipitate formed was filtered, washed with CH3CN (2×10 mL) and dried.2-Phenyl-5-trifluoromethoxybenzimidazole. Benzaldehyde was used, Ar=C6H5. Yield 0.76 g (71 wt. %). M.p. 208-210 C. 1H NMR (DMSO-d6): 7.31 (d, J=8.5 Hz, 1H), 7.38 (m, 2H), 7.49 (t, J=8.5 Hz, 1H), 7.83 (s, 1H), 7.95 (d, J=8.5 Hz, 1H), 8.57 (d, J=7.0 Hz, 2H). 13C NMR (DMSO-d6): 107.87, 115.26, 116.42, 120.21 (q, J=255.1 Hz), 126.90, 127.98, 128.84, 130.73, 135.91, 138.10, 144.17, 152.51. 19F NMR (DMSO-d6): -57.60. [M+1]+ 279.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(Trifluoromethoxy)benzene-1,2-diamine, other downstream synthetic routes, hurry up and to see.