Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16618-68-1, name is 3-Bromo-5-methoxyaniline, A new synthetic method of this compound is introduced below., category: ethers-buliding-blocks
(i) 3-Methoxy-5-((triisopropylsilyl)ethvnyl)aniline Pd(PPh3)4 (286 mg, 0.247 mmol) was added to a degassed suspension of 3-bromo-5- methoxyaniline (500 mg, 2.475 mmol), Cu(l) iodide (47.1 mg, 0.247 mmol), and ethynyltriisopropylsilane (0.833 mL, 3.71 mmol) in TEA (3 mL) and DMF (3 mL). Heated at 80C (block temp.) for 1 h then partitioned between ethyl acetate (20 mL) and saturated NH4CI solution (20 mL). The organics were separated, and washed with 20%w/w NaCI solution, separated, dried (MgS04) filtered and solvents evaporated. The crude product was purified by chromatography on the Companion (12 g column, 10% EtOAc:isohexane to 40%) to afford the sub-title compound (430 mg) as a clear brown oil. 1 H NMR (400 MHz, CDCI3) delta 6.44 (s, 1 H), 6.43 (s, 1 H), 6.20 (t, 1 H), 3.76 (s, 3H), 3.68 (s, 2H), 1.12 (s, 21 H). LCMS m/z 304 (M+H)+ (ES+)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.