Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22236-10-8, name is 4-(Difluoromethoxy)aniline, A new synthetic method of this compound is introduced below., Computed Properties of C7H7F2NO
General procedure: N-substituted benzylidene pyrrolidine dione (0.5 mol),0.6 mmol TBTU, and 0.6 mmol EDCI were dissolved in 2mL DCM and 0.75 mmol DIEA mixture solution and stirred for 30 min. Next, 0.5 mol of amine or methylamino acid in DCM (8 mL) solution was slowly added to the solution and stirred at room temperature for 4-10 h with the TLC monitoring reaction. After the reaction was complete, the resultant solution was washed with dilute hydrochloricacid and saturated sodium bicarbonate solution, then dried with anhydrous sodium sulfate, followed by column chromatography separation. The target product was obtained by crystallization.The yield ranged from 72 to 90%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.