Tag: M.W=100-200

Application of 645-36-3, A common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, molecular formula is C6H15NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixed solution of a commercially available product of 2,2-diethoxyethan-1-amine (926 pL, 6.39 mmol), THF (10.0 mE) and acetic acid (1.00 mE) was added a commercially available product of 6-fluoropyridine-2-carb- aldehyde (800 mg, 6.39 mmol) at room temperature. The resultant mixture was stirred at room temperature for 25 minutes. Subsequently, sodium triacetoxyborohydride (2.71 g, 12.8 mmol) was added to the reaction mixture at room temperature and then stirred for 1 hour and 10 minutes. To the reaction mixture was added sodium hydrogen carbonate and water to terminate the reaction. The resultant solution was extracted with ethyl acetate. An organic layer was dried over anhydrous magnesium sulfate and then filtrated. The solvent was evaporated under a reduced pressure, and the resultant residue was purified by NH silica gel colunm chromatography (heptane:ethyl acetate=1 :1), and was then thrther purified by silica gel column chromatography (ethyl acetate_methanol=20: 1) to give the title compound (1.14 g, yield: 74%).?H-NMR Spectrum (400 MHz, CDC13) oe (ppm):1.22 (6H, t, J=7.2 Hz), 2.76 (2H, d, J=5.5 Hz), 3.50-3.61(2H, m), 3.65-3.76 (2H, m), 3.89 (2H, s), 4.64 (1H, t, J=5.5Hz), 6.80 (1H, dd, J=2.8 Hz, 8.2 Hz), 7.22 (1H, dd, J=2.4 Hz,7.3 Hz), 7.74 (1H, q, J=7.9 Hz)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Synthetic Route of 22483-09-6, A common heterocyclic compound, 22483-09-6, name is 2,2-Dimethoxyethanamine, molecular formula is C4H11NO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Benzyl chloroformate (231.3 g, 1.3 mol) was added gradually to a mixture of aminoacetaldehyde dimethyl acetal (152.0 g, 1.3 mol) in toluene (750 mL) and aqueous NaOH (72.8 g, 1.82 mol; in 375 mL of water) at 10-20 C. After the addition was complete, the mixture was stirred at ambient temperature for 4 h. The organic layer was separated, washed with brine (2×100 mL) and concentrated to provide the title compound. MS (DCl/NH3): m/z 240 (M+1)+, 257 (M+18)+.

The synthetic route of 22483-09-6 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 437-83-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 437-83-2 as follows.

A mixture of (3-fluoro-2-methoxyphenyl)amine (5 g, 35.4 mmol) and 2,6-lutidine (7.4 mL, 64 mmol) in dichloromethane (20 mL) was treated at O0C dropwise with a solution of cinnamoylchloride (7.08 g, 42.5 mmol) in dichloromethane (30 mL). The reaction mixture was allowed to reach room temperature and was stirred over night. It was quenched with potassium phosphate buffer (50 mL, IM, pH 7) and stirred for 15 minutes. Dichloromethane was removed under reduced pressure and it was extracted with ethyl acetate. The organic phase was washed with phosphate buffer (like above, 100 mL), dried over sodium sulfate and concentrated to dryness. The residue was crystallized from ethyl acetate/ hexanes and then recrystallized from hexanes to give the product as colorless solid (6.21 g, 65%), mp 8O0C. MS (ESP^; 272 (MH+) for C16H14FNO21H-NMR (DMSO-AO delta: 3.88 (s, 3H); 6.97-7.12 (m, 2H); 7.23 (d, IH); 7.38-7.48 (m, 3H); 7.56-7.65 (m, 3H); 8.05 (m, IH); 9.61 (s, IH).

According to the analysis of related databases, 437-83-2, the application of this compound in the production field has become more and more popular.

Application of 36865-41-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 36865-41-5 as follows.

A 250 mL round-bottomed flask was charged with 5-bromo-2-chloro-phenol (22 g, 106 mmol), 1-bromo-3-methoxy-propane (19.5 g, 127 mmol), K2CO3 (30 g, 212 mmol) and DMF (50 mL). The resultant mixture was stirred at 50 C. for 3 hours, then ethyl acetate and water were added. The organic phase was separated, and then dried over anhydrous Na2SO4 and then concentrated to give 4-bromo-1-chloro-2-(3-methoxypropoxy)benzene (30 g).

According to the analysis of related databases, 36865-41-5, the application of this compound in the production field has become more and more popular.

Related Products of 1535-75-7, These common heterocyclic compound, 1535-75-7, name is 2-(Trifluoromethoxy)aniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Acetamides (1a-1x, 1ab, 1ac and 1ba-1bc). To a solution of 2-phenylacetic acid (7.0mmol), 2-(trifluoromethoxy)aniline (7.7mmol) in anhydrous CH2Cl2 (25mL) were added EDCI (1.745g, 9.1mmol) and DMAP (256.6mg, 2.1mmol). The reaction mixture was stirred at room temperature overnight, diluted with HCl (1M) aqueous solution, and extracted with CH2Cl2 (3×25mL). The combined organic phase was washed with saturated NaHCO3 aqueous solution and brine, dried over anhydrous Na2SO4, and concentrated under vacuum. Purification by flash chromatography (Silica gel, petroleum ether: ethyl acetate=50: 1 as eluent) gave the corresponding 2-phenyl-N-[2-(trifluoromethoxy)phenyl]acetamide compound.

The synthetic route of 1535-75-7 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 79128-08-8, name is 1,3-Diisopropoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 79128-08-8, Formula: C12H18O2

General procedure: A solution of 1,3-dialkoxybenzene (5.2 mmol) in dry THF(31 mL) was cooled to 0 C and treated with a 1.66 M solution of butyllithium in hexane (6.2 mmol). The mixture was left under magnetic stirring at room temperature for 2 h, added with dry DMF (1.0 mL, 12.9 mmol), left under stirring for additional 2 h and finally hydrolyzed with 0.5 M HCl (50 mL). The two phases were stirred for 30 min then separated. The aqueous phase was extracted with Et2O (3 20 mL) and the extracts were combined with the organic phase and dried (Na2SO4). After removal of the solvent at reduced pressure the crude benzaldehydes were obtained and purified as described below.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,3-Diisopropoxybenzene, other downstream synthetic routes, hurry up and to see.

41406-00-2, name is 3-Isopropoxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C9H13NO

EXAMPLE 1 Synthesis of o-trifluoromethyl-m’-isopropoxybenzoic anilide. To a tetrahydrofuran solution containing 1.5 g (0.01 mole) of m-isopropoxyaniline and 1.2 g (0.011 mole) of triethylamine, while being cooled in ice water, was added slowly 2.3 g (0.011 mole) of o-trifluoromethylbenzoyl chloride. After having been stirred for 2 hours at room temperature, the reaction mixture was freed from triethylamine hydrochloride by filtration and then from the solvent by distillation under reduced pressure. The residue was recrystallized from n-hexane to obtain 2.9 g (91% yield) of the intended product melting at 95 to 97 C.

The synthetic route of 41406-00-2 has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 645-36-3, name is 2,2-Diethoxyethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 645-36-3

4-(2-bromoethyl)heptane (4.14 g, 1.0 eq, 20 mmol) was dissolved in 30 mL of DMF and the amino acetal was added(2.66 g, 1.0 eq, 20 mmol) and K2CO3 (5.5 g, 2.0 eq, 40 mmol).After the reaction solution was reacted at 100 C. for 6 hours, the reaction was completed by TLC (PE:EA=1:1).The reaction solution was poured into water (50 mL) and extracted with ethyl acetate (50 mL x 3).The combined reaction solution was washed successively with saturated aqueous NH 4 Cl (50 mL×3), water (30 mL) and saturated brine (30 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to give the product as a yellow oil (4.2 g, Y=81.1%). .

The synthetic route of 2,2-Diethoxyethanamine has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 645-36-3, name is 2,2-Diethoxyethanamine, A new synthetic method of this compound is introduced below., Formula: C6H15NO2

Dissolve N- (2-chloropyrimidine-4-substituted) -4-fluorobenzamide (5g, 19.9mmol) in toluene (50mL), cool to 0 C, and slowly drop in dichlorosulfoxide under nitrogen protection (7.1 g, 59.8 mmol), transferred to room temperature for 1 hour, and then refluxed overnight. TLC monitoring, after the reaction was completed, the solvent and dichlorosulfoxide were removed to obtain (Z) -N- (2-chloropyrimidine-4-substituted) -4-fluorobenzimidyl chloride.Dissolve aminoacetaldehyde diethanol (3.5 g, 23.9 mmol) and TEA (4.0 g, 39.8 mmol) in dichloromethane (100 mL), cool to 0 C, and obtain (Z) -N- (2-Chloropyrimidine-4-substituted) -4-fluorobenzimidyl chloride was dissolved in dichloromethane (100 mL), and the solution was slowly added dropwise. The mixture was naturally warmed to room temperature and stirred overnight. Monitored by TLC. After the reaction was completed, the mixture was washed with a saturated ammonium chloride aqueous solution and a saturated saline solution, dried over anhydrous Na2SO4, filtered, and dried. Purification by silica gel column chromatography gave a yellow solid (7 g, 95.7%).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Some common heterocyclic compound, 1535-75-7, name is 2-(Trifluoromethoxy)aniline, molecular formula is C7H6F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 2-(Trifluoromethoxy)aniline

General procedure: Under nitrogen atmosphere, dry CH2Cl2 (30 mL), amine (0.02 mol), and Et3N (0.05 mol) wereadded to a three-necked round bottom ask and stirred for 0.5 h, then chloroacetyl chloride droppedslowly and reacted for 3 h at room temperature. Then, the solution was washed with 2 mol L1hydrochloric acid (30 mL), saturated aq NaHCO3 solution (30 mL), and brine (40 mL), successively,then dried over anhydrous Na2SO4 and filtered. After evaporating CH2Cl2 in vacuum, the obtainedcrude product was rened by recrystallization using ethyl acetate/petroleum ether.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1535-75-7, its application will become more common.