Synthetic Route of 437-83-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 437-83-2 as follows.
A mixture of (3-fluoro-2-methoxyphenyl)amine (5 g, 35.4 mmol) and 2,6-lutidine (7.4 mL, 64 mmol) in dichloromethane (20 mL) was treated at O0C dropwise with a solution of cinnamoylchloride (7.08 g, 42.5 mmol) in dichloromethane (30 mL). The reaction mixture was allowed to reach room temperature and was stirred over night. It was quenched with potassium phosphate buffer (50 mL, IM, pH 7) and stirred for 15 minutes. Dichloromethane was removed under reduced pressure and it was extracted with ethyl acetate. The organic phase was washed with phosphate buffer (like above, 100 mL), dried over sodium sulfate and concentrated to dryness. The residue was crystallized from ethyl acetate/ hexanes and then recrystallized from hexanes to give the product as colorless solid (6.21 g, 65%), mp 8O0C. MS (ESP^; 272 (MH+) for C16H14FNO21H-NMR (DMSO-AO delta: 3.88 (s, 3H); 6.97-7.12 (m, 2H); 7.23 (d, IH); 7.38-7.48 (m, 3H); 7.56-7.65 (m, 3H); 8.05 (m, IH); 9.61 (s, IH).
According to the analysis of related databases, 437-83-2, the application of this compound in the production field has become more and more popular.