Tag: M.W=100-200

Related Products of 7252-83-7, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7252-83-7 as follows.

4-Hydroxythiobenzamide (0.20 mol) and 2-bromo-1,1-dimethoxyethane (0.20 mol) were stirred in ethanol (600 mL) at room temperature and p-toluenesulfonic acid (0.20 mol) was added. Into the reaction solution. Heat to 90 C for 24 h. After the reaction was completed, it was cooled to room temperature, and the solvent was evaporated under reduced pressure, and water (200 mL) was added.The pH was adjusted to 8 with saturated sodium bicarbonate solution, extracted with dichloromethane (200 mL¡Á3), and the organic phases were combined.Concentration under reduced pressure and distillation gave 2-(4-hydroxyphenyl)thiazole.

According to the analysis of related databases, 7252-83-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Ocean University of China; Shao Changlun; (69 pag.)CN108658937; (2018); A;,
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Adding a certain compound to certain chemical reactions, such as: 24332-20-5, name is 1,1,2-Trimethoxyethane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 24332-20-5, COA of Formula: C5H12O3

Reaction of cis – cedimnylene glycol with methoxyacetaldehyde dimethylacetal24 g (0.1 mol) of cis-cedrylene glycol (using 26 g of a GC content of 92%), 127.6 g (1.45 mol)Methoxyacetaldehyde dimethyl acetal and 0.4 g of concentrated sulfuric acid were stirred at 10 C for 24 hours. At the end of the reaction, methyl tert-butyl was addedEther, washed with a 5% solution of sodium hydrogencarbonate, and the low boiling components removed by distillation. After the addition of n-hexane, unreacted cis-isomer was addedType – cypressane diol crystallization, filtration separation. After concentration of the filtrate by evaporation, 30.4 g of crude product was obtained. According toThe content of the compounds of formulas (X) and (XI) in the product obtained by GC analysis was 51% (corresponding to a theoretical yield of 50%). The originalThe material was dissolved in dipropylene glycol (DPG) to prepare a solution of the compound of formulas (X) and (XI) in an amount of 10% by weightExample (VIII): (IX) = 1: 6.2).For analytical purposes, cyclohexane / ethyl acetate eluant (60/1) was passed through silica gel 60 (0.04-0.063 mm)(X) and (XI) in the crude product were separated from each other by liquid chromatography on a liquid chromatograph. (X)Of the compound has a purity of 99.4% and the purity of the compound of formula (XI) is 96.9%.Compounds of formula (X): & lt; EMI ID =

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,1,2-Trimethoxyethane, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Simrose Corporation; Bei, Ende hhuoersiche; (41 pag.)CN105228993; (2016); A;,
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Reference of 1535-73-5,Some common heterocyclic compound, 1535-73-5, name is 3-Trifluoromethoxyaniline, molecular formula is C7H6F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 62: 3-(5-Oxo-4,5,6,7,8,9-hexahydro-2H-1,2,7,9-tetraazabenz[f]inden-4-yl)-N-(4-trifluoromethoxy-phenyl)-benzamide; compound with trifluoro-acetic acid Preparation of the aldehyde: to a solution of 300 mg of 4-carboxybenzaldehyde (2 mmoles) and 382 mg of 4-(trifluoromethoxy)aniline (2 mmoles) in 5 ml of ethyl acetate is added 830 mg of dicyclohexycarbodiimide) (DCC) (4 mmoles). The reaction mixture is heated at 60¡ãC overnight and then poured into 60 ml of 1 N HCl solution. The mixture is extracted with twice 30 ml of ethyl acetate. The combined organic phases are washed with 50 ml of water; 50 ml saturated solution of sodium bicarbonate and brine, dried over MgSO4 and evaporated. The crude is purified on silica gel giving 233 mg of 4-Formyl-N-(3-trifluoromethoxy-phenyl)-benzamide (yield=38percent). ([M+H]+): 310). Ret. Time: 5.60 min (gradient 5 to 85 percent acetonitrile in 7 min).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Trifluoromethoxyaniline, its application will become more common.

Reference:
Patent; Aventis Pharma S.A.; EP1746097; (2007); A1;,
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Electric Literature of 2339-58-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 2339-58-4, name is 3-Fluoro-5-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a solution of 3-(trifluoromethyl)aniline(5.0 g, 31 mmol) and trimethyl orthoformate (4.9 g, 46.5mmol) was added three drops of sulfuric acid.This mixture was slowly heated to 120 oC to allow MeOH to be distilled off, stirred for 2 h at 120 oC, heated to 170 oCfor 30 min, and cooled to 100 oC.Then aq. HCl (10%; 25 mL) was added.This mixture was then refluxed for 3 h, cooled to 0 oC (ice bath) and finally basified with aq. NaOH (20%).This solution was extracted with EtOAc (3 ¡Á 30 mL), dried (MgSO4), filtered, and concentrated under reduced pressure. The crudeproduct was purified on a silica gel column with gradient elution (hexanes hexane-EtOAc; 1: 10 v/v) to afford S7 as a colorless oil

The synthetic route of 3-Fluoro-5-methoxyaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Naumiec, Gregory R.; Cai, Lisheng; Pike, Victor W.; Bioorganic and Medicinal Chemistry Letters; vol. 25; 2; (2015); p. 225 – 228;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, This compound has unique chemical properties. The synthetic route is as follows., Formula: C10H10O2

General procedure: The azido-sugar 2(1 equiv) was dissolved in dry THF (45 mL/mmol) and the required alkyne derivative (5.4 equiv), diisopropylethylamine(1.9 equiv), CuI (0.57 equiv) and DMEDA (5.2 equiv) were added. The reaction mixture was heated to reflux until TLC indicated complete consumption of 2, then the solvent was removed.The residue was dissolved in EtOAc and washed with H2O twice and once with an aqueous solution of EDTA (1%,m/v). The organic layer was dried over MgSO4, filtered and the solvent removed. Purification of the crude material on column chromatography on silica gel (CH2Cl2/EtOAc) afforded the desired product

According to the analysis of related databases, 171290-52-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Van Nguyen, Tai; Hospital, Audrey; Lionne, Corinne; Jordheim, Lars P.; Dumontet, Charles; Perigaud, Christian; Chaloin, Laurent; Peyrottes, Suzanne; Beilstein Journal of Organic Chemistry; vol. 12; (2016); p. 1476 – 1486;,
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Reference of 910251-11-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 910251-11-5, name is Potassium trifluoro(methoxymethyl)borate belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Ethyl (R)-l l-chloro-12-(3-hydroxy-3-methylbut-l-yn-l-yl)-3,3- dimethyl-8-oxo-2,3,8,13b-tetrahydro-lH-pyrido[2,l-a]pyrrolo[l,2-c]phthalazine-7-carboxylate (53 mg, 0.093 mmol) was combined with trifluoro(methoxymethyl)-borane, potassium salt (40 mg, 0.26 mmol), Ruphos Pd G2 (5.1 mg, 0.007 mmol), and potassium carbonate (52 mg, 0.37 mmol) in dioxane:water (5: 1, ImL) under argon in a sealed vial. The mixture was stirred at 110 C for 2.5 hours, after which time it was cooled to 50 C and 1M lithium hydroxide (0.19 ml) was added. The mixture was stirred for 90 minutes, then cooled to room temperature, diluted with TFA and acetonitrile, and purified by preparative HPLC to provide (R)-12-(3-hydroxy-3- methylbut- 1 -yn-1 -yl)- 11 -(methoxymethyl)-3,3-dimethyl-8-oxo-2,3,8, 13b-tetrahydro- 1H- pyrido[2,l-a]pyrrolo[l,2-c]phthalazine-7-carboxylic acid as a TFA salt. XH NMR (400 MHz, Acetonitrile-d3) delta 8.47 (s, 1H), 8.01 (s, 1H), 7.50 (d, J = 1.1 Hz, 1H), 7.29 (s, 1H), 4.88 (d, J = 5.9 Hz, 1H), 4.62 (t, J = 0.8 Hz, 2H), 3.47 (s, 3H), 2.60 – 2.43 (m, 2H), 1.94 – 1.86 (m, 1H), 1.67 – 1.60 (m, 1H), 1.58 (s, 6H), 1.37 (s, 3H), 0.63 (s, 3H). iyF NMR (376 MHz, Acetonitrile- d3) delta -77.28 . MS (m/z) 437.2 [M+H]+.

The synthetic route of Potassium trifluoro(methoxymethyl)borate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; GILEAD SCIENCES, INC.; AKTOUDIANAKIS, Evangelos; CANALES, Eda; CURRIE, Kevin S.; KATO, Darryl; LI, Jiayao; LINK, John O.; METOBO, Samuel E.; SAITO, Roland D.; SCHROEDER, Scott D.; SHAPIRO, Nathan; TSE, Winston C.; WU, Qiaoyin; (262 pag.)WO2018/144605; (2018); A1;,
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Reference of 1836-62-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

d) (3,4-Dihydro-quinazolin-2-yl)-[2-(2-methoxy-phenoxy)-ethyl]-amine 2-(2-Methoxy-phenoxy)-ethylamine (42 mg, 0.25 mmol) was added to a solution of 2-methylsulfanyl-3,4-dihydro-quinazoline hydroiodide (70 mg, 0.23 mmol) in acetonitrile (1 ml), and the mixture was heated overnight (80 C.) in a screw-capped vial. The title compound (42 mg, 62%) was then isolated from the reaction mixture by preparative, reverse-phase HPLC (YMC CombiPrep C18 column 50¡Á20 mm, solvent gradient 5-95% CH3CN in 0.1% TFA(aq) over 6.0 min, lambda=230 nm, flow rate 40 ml/min). MS: m/e=298.2 [M+H+]. 1H NMR (CDCl3): delta 3.71 (3H, s), 3.91 (2H, t), 4.16 (2H, t), 4.57 (2H, s), 6.85-7.01 (8H, m), 7.80 (1H, bs), 8.63 (1H, s).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Methoxyphenoxy)ethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Alanine, Alexander; Gobbi, Luca Claudio; Kolczewski, Sabine; Luebbers, Thomas; Peters, Jens-Uwe; Steward, Lucinda; US2006/252779; (2006); A1;,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 458-52-6 as follows. Recommanded Product: 2-Fluoro-4-methoxyaniline

A mixture of (+-)-4-[trans-3-(tert-butyl-dimethyl-silanyloxy)-cyclopentyl-amino]-2-methylsulfanyl-pyrimidine-5-carbaldehyde (171 mg, 0.46 mmol) (from Example 13a supra), p-toluenesulfonic acid mono-hydrate (10 mg) (Aldrich) and 2-fluoro-4-methoxyaniline (79 mg, 0.56 mmol) (from Example 14a supra) in benzene (30 ML) was refluxed in a Dean-Stark apparatus for 8 hours.The mixture was then cooled and partitioned between ethyl acetate and saturated aqueous potassium carbonate.The organic layer was collected, dried over sodium sulfate, filtered and concentrated.The residue was dissolved in anhydrous tetrahydrofuran (50 ML) and to this solution was added in small portions lithium aluminum hydride (53 mg, 1.40 mmol) (Aldrich) at 0¡ã C. The slurry was allowed to slowly warm up to room temperature and after overnight stirring was poured slowly into a vigorously stirred mixture of ethyl acetate and saturated aqueous potassium sodium tartrate solution.The organic layer was collected, dried over sodium sulfate, filtered and concentrated to a residue that upon purification by silica gel column chromatography with a 0-60percent ethyl acetate in hexanes gradient gave (+-)-[3-trans-(tert-butyl-dimethyl-silanyloxy)-cyclopentyl]-{5-[(2-fluoro-4-methoxy-phenylamino)-methyl]-2-methylsulfanyl-pyrimidin-4-yl}-amine as a colorless viscous oil. (Yield 187 mg, 83percent). HRMS m/z calculated for C24H37FN4O2SSi [M+H]+: 493.2464. Found: 493.2472.

According to the analysis of related databases, 458-52-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Chen, Yi; Dermatakis, Apostolos; Liu, Jin-Jun; Luk, Kin-Chun; Michoud, Christophe; Rossman, Pamela Loreen; US2004/204427; (2004); A1;,
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Electric Literature of 2398-37-0, A common heterocyclic compound, 2398-37-0, name is 1-Bromo-3-methoxybenzene, molecular formula is C7H7BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The advantageous effect of adding zinc chloride to an amination reaction was demonstrated in the amination reaction of 3-bromoanisole. the results of which are summarized in Table 10. When 3-bromoanisole was reacted under the standard lithium amide amination conditions, using lithium amide (10 eq.) in the presence of (CyPF-^-Bu)PdCl2 (1 mol%) in DME gave a complicated mixture of products was obtained (Table 10, Entry 1). When conducted in the presence of zinc chloride and TMEDA, however, the reaction could successfully gave the desired monoarylation product, 3-methoxyaniline, although at high concentrationsN,N-dimethyl-3-methoxyaniline was formed in a significant amount as a by- product (Table 10, Entries 3 and 4). Under optimized conditions (Table 10, Entries 8 and 9), 3-methoxyaniline was formed selectively in good yield.

The synthetic route of 2398-37-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; YALE UNIVERSITY; WO2007/109365; (2007); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 658-89-9, name is 4-(Trifluoromethoxy)benzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-(Trifluoromethoxy)benzene-1,2-diamine

To a mixture of 4-(trifluoromethoxy)benzene-1,2-diamine (0.1 g, 521 imol, 1 eq) in 2 mL of dichloromethanecooled to 0C was added methyl 2,2,2-trichloroethanimidate (119 mg, 676 imol, 1.3 eq), TFA(148 mg, 1.3 mmol, 2.5 eq) successively. The mixture was stirred at 25C for 12 hours underN2 atmosphere. The mixture was filtered and the filtrate was purified by prep-TLC (Si02,eluting with petroleum ether: ethyl acetate = 2:1) to give a 0.1 g of compound J-3 (44% yield,TFA salt) as a yellow solid.

According to the analysis of related databases, 658-89-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
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