Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 658-89-9, name is 4-(Trifluoromethoxy)benzene-1,2-diamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 4-(Trifluoromethoxy)benzene-1,2-diamine
To a mixture of 4-(trifluoromethoxy)benzene-1,2-diamine (0.1 g, 521 imol, 1 eq) in 2 mL of dichloromethanecooled to 0C was added methyl 2,2,2-trichloroethanimidate (119 mg, 676 imol, 1.3 eq), TFA(148 mg, 1.3 mmol, 2.5 eq) successively. The mixture was stirred at 25C for 12 hours underN2 atmosphere. The mixture was filtered and the filtrate was purified by prep-TLC (Si02,eluting with petroleum ether: ethyl acetate = 2:1) to give a 0.1 g of compound J-3 (44% yield,TFA salt) as a yellow solid.
According to the analysis of related databases, 658-89-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; AQUINNAH PHARMACEUTICALS, INC.; BURNETT, Duane, A.; VACCA, Joseph, P.; (310 pag.)WO2018/119395; (2018); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem