Tag: M.W=100-200

Application of 6781-17-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6781-17-5, name is 2-(2-Ethoxyphenoxy)ethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Example 14 (3-Benzenesulfonyl-propyl)-[2-(2-ethoxy-phenoxy)-ethyl]-amine oxalate A mixture of [(3-bromopropyl)sulfonyl]benzene (26.3 g, 100 mmol), 2-(2-ethoxyphenoxy)ethanamine (18.1 g, 100 mmol), and potassium carbonate (55.3 g, 400 mmol) in 200 mL of methyl ethyl ketone is heated at reflux for 18 hours. The reaction mixture is cooled, filtered, and the filtrate is evaporated. The residue is dissolved in warm 2-propanol and treated with oxalic acid (9.3 g, 101 mmol). The precipitated salt is filtered and recrystallized from 2-propanol to yield 3.2 g (7%) of product, mp 184-188 C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-(2-Ethoxyphenoxy)ethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Warner-Lambert Company; US6051605; (2000); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 19500-02-8, name is 3-Methoxy-2-methylaniline, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 19500-02-8

2-Methoxy-4-bromotoluene; Crude 2-methoxy-6-amino-toluene (max. 120 mmol) was suspended in HBr (48percent, 48 ml) and water (120 ml) and cooled to 0¡ãC in an ice bath. Sodium nitrite (9.2 g) in water (24 ml) was added dropwise to the cold mixture, which turned yellow then brown. After 10 min, excess nitrite was destroyed by addition of urea (0.08 g) and the mixture was rapidly filtered into cold (0¡ãC) acetone (480 ml) to give a bright yellow solution. CuBr (99.999percent, 18.89,131 mmol) was then added portionwise and the resulting mixture stirred at 0¡ãC for 3h. Gas evolution was observed. The mixture was allowed to warm to ambient temperature, and then concentrated in vacuo. Dichloromethane was then added and the mixture washed with sat. aq. sodium bicarbonate solution. The organic layer was separated, dried over magnesium sulphate and concentrated in vacuo to give the product (23.1 g, 96percent) as a red oil. No.H (CDCl3; 250MHz) 7.18-6.77 (3H, m, aromatics), 3.83 (3H, s, OCH3), 2.32 (3H, s, CH3).

According to the analysis of related databases, 19500-02-8, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ARAKIS LTD.; WO2005/103019; (2005); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 41365-75-7,Some common heterocyclic compound, 41365-75-7, name is 1-Amino-3,3-diethoxypropane, molecular formula is C7H17NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of intermediate I-05a (300 mg, 748 mumol) and 3,3-diethoxypropan-1-amine (R-04a, 110 mg, 748 mumol) in 1,4-dioxane (10 mL), was added Pd(dba)2 (43 mg, 74 mumol), BINAP (47 mg, 75 mumol) and Cs2CO3 (487 mg, 1 .50 mmol) in one portion at 25C under N2. The mixture was stirred at 25C for 10 minutes and then heated to 110C and stirred for 12 hours. Then, the mixture was concentrated in vacuum and the residue was purified by prep-TLC to afford intermediate I-11a (250 mg, 65%) as yellow solid. ESI-MS (M+1): 512.3 calc. for C29H41N3O5: 511.3.

The synthetic route of 41365-75-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; FUNDACION PARA LA INVESTIGACION MEDICA APLICADA; AGUIRRE ENA, Xabier; OYARZABAL SANTAMARINA, Julen; PROSPER CARDOSO, Felipe; RABAL GRACIA, Maria Obdulia; SAN JOSE ENERIZ, Edurne; SANCHEZ ARIAS, Juan Antonio; (92 pag.)WO2017/85053; (2017); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 4179-19-5, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4179-19-5, name is 3,5-Dimethoxytoluene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

5 mg of 3,5-trimethoxytoluene (76 mg), 1,3-dimethoxybenzene (69 mg) or 1,3-bisEthoxybenzene (83 ¡¤ lmg), 0.75 mmol of sodium p-methoxybenzenesulfinate (145.6 mg), and 1.2 mmol of hydrochloric acid (36.5% of hydrochloric acid, 102.6 mil) were added to a pressure- 0.5 mL of ionic liquid was reacted at 120 C for 6 h. After the reaction was complete, the mixture was extracted three times with 2 mL of ethyl acetate. The organic solvent was removed by steaming and passed through a column of silica gel to give the target product 4a-4c in 88% yield, 86%, 91%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dimethoxytoluene, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Nanjing University of Science and Technology; Lu, Guoping; Xu, Zhu Bing; Wu, Tongbo; (7 pag.)CN106543051; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of 1535-73-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1535-73-5 name is 3-Trifluoromethoxyaniline, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: The carboxylic acid (0.8 mmol), HATU (hexafluorophosphateazabenzotriazole tetramethyl uranium) (455 mg, 1.2 mmol) and triethylamine (324 mg, 3.2 mmol) were stirred for 30 min in 20 mL dichloromethane. The corresponding amine (1.19 mmol) was added to the reaction mixture and stirred overnight. The resulting solid was filtered, washed with dichloromethane and crystallized from methanol unless otherwise noted. Purification was carried out over silica gel chromatography till purity reached >95percent.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 3-Trifluoromethoxyaniline, and friends who are interested can also refer to it.

Reference:
Article; Shahin, Mai I.; Roy, Joyeeta; Hanafi, Maha; Wang, Dongyao; Luesakul, Urarika; Chai, Yifeng; Muangsin, Nongnuj; Lasheen, Deena S.; Abou El Ella, Dalal A.; Abouzid, Khaled A.; Neamati, Nouri; European Journal of Medicinal Chemistry; vol. 155; (2018); p. 516 – 530;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 3616-56-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 3616-56-6, name is 2,2-Diethoxy-N,N-dimethylethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Intermediate IV andBromo-2,3-dihydro-1H-pyrrolo (2,3-b) pyridine to give d,React with (S) -3-hydroxytetrahydrofuran,A dark yellow solid VId was obtained.The intermediate d with activated carbon,Ferric chloride and hydrazine hydrate reduction,Obtained as an off-white solid VIId.Then VIId and diethyl phosphoric acid condensation,Compound VIIId is obtained,In the condensation with (dimethylamino) acetaldehyde diethyl acetal,The target compound was obtained. Yield: 48.7percent.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,2-Diethoxy-N,N-dimethylethanamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Jiangxi Science and Technology Normal University; Zhu Wufu; Zheng Pengwu; Ouyang Yiqiang; Tang Qidong; Xu Shan; Tu Yuanbiao; Duan Yongli; Lei Huajun; Wang Caolin; (23 pag.)CN106831725; (2017); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 592-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 592-55-2, name is 1-Bromo-2-ethoxyethane, This compound has unique chemical properties. The synthetic route is as follows.

4-Nitro-1 H-pyrazole-3, 5-dicarboxylic acid dimethyl ester (2. 0g, 8. 83MMOL) was added to a solution of 2-ethoxyethyl bromide (1. 18ML, 10. 45mmol) and potassium carbonate (1.32g, 9. 56MMOL) in N, N-dimethylformamide (35mL) and the reaction mixture stirred-for 48 hours at room temperature. The reaction mixture was concentrated IN VACUO and partitioned between ethyl acetate (200mL) and water (100ML). The organic layer was separated, dried over magnesium sulphate and concentrated in vacuo The crude product was purified by column chromatography on silica gel eluting with pentane: ethyl acetate 100: 0 to 70: 30 to yield the title product, 1.63g. ‘H NMR (CDCI3, 400MHZ) B : 1.07 (t, 3H), 3.41 (q, 2H), 3.73 (t, 2H), 3.89 (s, 3H), 3.94 (s, 3H), 4.76 (t, 2H). LRMS: m/z APCI+ 302, [MH] +

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-ethoxyethane. I believe this compound will play a more active role in future production and life.

Reference:
Patent; PFIZER LIMITED; PFIZER INC.; WO2004/96810; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 707-07-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 707-07-3, name is (Trimethoxymethyl)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a cooled (-78C) solution of 25 (200mg, 0.26mmol), in dry THF (2.6mL), was slowly added a solution of LiAlH4 (2M in THF, 130muL, 0.26mmol). The reaction mixture was stirred 30min at -78C, warmed to room temperature, and stirred 1h at room temperature. The reaction mixture was quenched with saturated aqueous NH4Cl and then extracted with t-BuOMe. The combined organic layer was washed with brine, dried (Na2SO4), and then concentrated under reduced pressure (water bath at room temperature). The residue was dissolved in dry CH2Cl2 (1mL) and CSA (6mg, 0.026mmol) and PhC(OMe)3 (160muL, 1.3mmol) were added. The reaction mixture was stirred overnight at room temperature, quenched with aqueous saturated NaHCO3, and then extracted with CH2Cl2. The combined organic layer was washed with brine, dried (Na2SO4), and then concentrated under reduced pressure (water bath at room temperature) and dried under strong vacuum. The residue was dissolved in dry CH2Cl2 (3mL), cooled at 0C, and then TMSCN (326muL, 2.6mmol) was added followed by the addition of BF3-Et2O (27muL, 0.26mmol). The reaction mixture was stirred 2h at 0C, warmed to room temperature and stirred 2h at room temperature. The reaction mixture was quenched with saturated aqueous NaHCO3 and then extracted with CH2Cl2. The combined organic layer was washed with brine, dried (MgSO4), and then concentrated under reduced pressure. The crude was purified on silica gel (10% t-BuOMe in heptane) to give 4 (160mg, 74%) as a clear viscous oil:

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, (Trimethoxymethyl)benzene, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Picard, Sebastien; Crich, David; Tetrahedron; vol. 69; 26; (2013); p. 5501 – 5510;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

929-75-9, name is 1,11-Diamino-3,6,9-trioxaundecane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. HPLC of Formula: C8H20N2O3

General procedure: Diester1 (1mmol) and the appropriate diamine2-6 (1mmol) were dissolved in dry methanol (50mL) and sodium methoxide (2mmol) was added. A mixture was stirring for 72hat room temperature. After completion of the reaction (controlled by TLC), the solvent was evaporated under reduced pressure and the oily residue was purified by column chromatography (1-5% MeOH in CH2Cl2). All the macrocyclic products obtained in this way are colourless solids, stable to air.

The synthetic route of 929-75-9 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Pikus, Grzegorz; Jurczak, Janusz; Tetrahedron; vol. 72; 16; (2016); p. 1928 – 1932;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 321-28-8, These common heterocyclic compound, 321-28-8, name is 1-Fluoro-2-methoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

[PENTAMETHYLENEDIETHYLENETETRAMINE] (31. [2ML)] was added to a solution of 2-fluoroanisole [(15.] 0g) in THF [(450ML).] The reaction mixture was cooled [TO-78C] and n-butyllithium (59. [6ML,] 2. 5M solution in hexanes) was added dropwise. Stirring was maintained for 2h before the solution was added in a dropwise fashion to a flask containing solid carbon dioxide pellets. Upon complete addition (30min) the mixture was allowed to warm to room temperature before removal of the volatiles in vacuo. The residue was dissolved in 10% sodium hydroxide solution [(300ML)] and extracted with Et20 (3x). The aqueous was acidified to pH 1 with concentrated hydrochloric acid before extracting with DCM. The organics were washed with [H20,] dried (MgS04) and concentrated in vacuo to afford the subtitle compound as a yellow solid. Yield: 7. [1G.] [LH NMR 6 (CDC13)] 7.50 [(1H,] [M),] 7.12 (2H, [M),] 3.91 (3H, s).

The synthetic route of 321-28-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2004/11443; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem