Tag: M.W=200-300

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Gasperin-Bulbarela, Jahaziel, once mentioned the application of 5111-65-9, Name is 2-Bromo-6-methoxynaphthalene, molecular formula is C11H9BrO, molecular weight is 237.09, MDL number is MFCD00004062, category is ethers-buliding-blocks. Now introduce a scientific discovery about this category, Recommanded Product: 5111-65-9.

Ca-Alginate-PEGMA Hydrogels for In Situ Delivery of TGF-beta Neutralizing Antibodies in a Mouse Model of Wound Healing

Hydrogels provide effective alternatives for drug delivery when therapeutics cannot be applied directly to a wound, or if adverse effects are associated with systemic administration. However, drug delivery vehicles need to be biocompatible and biodegradable and exhibit sufficient mechanical strength to withstand handling and different physiological conditions, such as those encountered during topical administration of a therapeutic. Wound healing can be divided into three phases stimulated by transforming growth factor-beta (TGF-beta) and, subsequently, targeted therapeutics have been developed to inhibit this cytokine for the treatment of chronic wounds and to prevent scarring. In this study, the capacity of calcium alginate hydrogels plasticized with poly(ethylene glycol) methyl ether methacrylate (PEGMA) to deliver anti-TGF-beta antibodies (1D11.16.8) to a wound was investigated in situ. Three levels of antibodies, 10, 50, and 100 mu g, were loaded into calcium-alginate-PEGMA hydrogels and evaluated in an excisional wound model in mice. Hydrogels containing 50 and 100 mu g 1D11.16.8 produced less inflammation, accompanied by a marked reduction in collagen deposition and cell infiltration. These findings demonstrate the capacity of calcium-alginate-PEGMA hydrogels to deliver larger proteins, such as antibodies, to the site of a wound.

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In an article, author is Tajbakhsh, Saeid, once mentioned the application of 101-55-3, SDS of cas: 101-55-3, Name is 1-Bromo-4-phenoxybenzene, molecular formula is C12H9BrO, molecular weight is 249.1033, MDL number is MFCD00000094, category is ethers-buliding-blocks. Now introduce a scientific discovery about this category.

Synthesis of bio-based poly(methacrylates) using SG1-containing amphiphilic macroinitiators by nitroxide mediated miniemulsion polymerization

SG1-based amphiphilic macroinitiators were synthesized from oligoethylene glycol methyl ether methacrylate and 10 mol% acrylonitrile or styrene (as the controlling comonomer) to conduct the nitroxide mediated polymerization of bio-based methacrylic monomers (isobornyl methacrylate (IBOMA) and C13 alkyl methacrylate (C13MA)) in miniemulsion. The effect of the addition of surfactant (DOWFAX 8390), co-stabilizer (n-hexadecane) and different reaction temperatures (80, 90 and 100 degrees C) on polymerization kinetics was studied. We found that the NMP of IBOMA/C13MA using amphiphilic macroalkoxyamines were most effective during miniemulsion polymerization (linear trend of M-n versus conversion and high latex stability) in presence of 2 wt% surfactant and 0.8 wt% co-stabilizer (relative to monomer) at 90 degrees C. The effect of surfactant, co-stabilizer and temperature on particle size during the polymerization was studied and suggested a decrease in initial particle size with the addition of surfactant and co-stabilizer. Finally, the thermal properties of IBOMA/C13MA polymers, prepared by amphiphilic macroinitiators, were examined thoroughly, indicating a T-g in the range of -44 degrees C < T-g < 109 degrees C. If you are interested in 101-55-3, you can contact me at any time and look forward to more communication. SDS of cas: 101-55-3.

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Park, Byoungchoo, once mentioned the application of 143-24-8, Name is 2,5,8,11,14-Pentaoxapentadecane, molecular formula is C10H22O5, molecular weight is 222.28, MDL number is MFCD00008505, category is ethers-buliding-blocks. Now introduce a scientific discovery about this category, Name: 2,5,8,11,14-Pentaoxapentadecane.

Simple and Efficient Perovskite Solar Cells with Multi-Functional Mixed Interfacial Layers

Recently, hybrid organic-inorganic perovskite solar cells (PVSCs) have attracted significant attention owing to their simple solution processability and high efficiency for the next generation of low-cost solar cell technology. Herein, a multi-functional interfacial layer (IFL) composed of a mixture of poly(oxyethylene tridecyl ether) (PTE) and ethanolamine (EA) is introduced between a CH3NH3PbI3 perovskite light-absorbing layer and a nickel oxide (NiOx) hole transport layer to improve the photovoltaic (PV) performance of PVSCs. With the solution-coated IFL of mixed PTE:EA, a highly improved film-forming capability of the perovskite layer is realized together with large-sized grains and fewer film defects. Moreover, the IFL also improved the charge carrier separation and hole-extraction capabilities at the interface between the CH3NH3PbI3 and the NiOx layers. The results here successfully demonstrate that the CH3NH3PbI3 PVSC with IFL exhibits greatly improved PV performance, in this case a much higher power conversion efficiency (15.1%), greatly exceeding that (12.3%) of a reference device without an IFL. The author’s study demonstrates that a multi-functional mixed IFL can be used as a solid foundation for efficient and cost-effective PVSCs, thus providing a platform for the realization of a new generation of highly efficient solution-processable PVSCs.

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Synthetic Route of 17715-69-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 17715-69-4 as follows.

General procedure: A suspension of Pd2(dba)3 (6.9 mg, 0.0075 mmol), tBu3PHBF4 (8.7 mg,0.03 mmol), KOH (42 mg, 0.75 mmol), aryl bromide 9 (0.36 mmol) and tetralone 10(0.3 mmol) in a mixture of dioxane/water (4:1, v/v, 3 mL) was degassed and heated under Ar and microwave irradiation (80W of initial power, 100 ¡ãC, 40min, infrared probe). Then, the mixture was allowed to cool to rt, diluted in AcOEt, washed with saturated NH4Cl solution, dried over anhydrous Na2SO4,filtered and concentrated under reduced pressure. The crude material was purified by silica gel chromatography.

According to the analysis of related databases, 17715-69-4, the application of this compound in the production field has become more and more popular.

Reference:
Article; Manvar, Dinesh; Fernandes, Talita De A.; Domingos, Jorge L.O.; Baljinnyam, Erdenechimeg; Basu, Amartya; Junior, Eurides F.T.; Costa, Paulo R.R.; Kaushik-Basu, Neerja; European Journal of Medicinal Chemistry; vol. 93; (2015); p. 51 – 54;,
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Application of 64115-88-4,Some common heterocyclic compound, 64115-88-4, name is 1-Bromo-2-(trifluoromethoxy)benzene, molecular formula is C7H4BrF3O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a microwave vial with stir bar was added 7-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-N-(3,4,5-trimethoxyphenyl)benzo[d]oxazol-2-amine (97 mg, 0.228 mmol), 4-bromo-1H-benzo[d]imidazole (30 mg, 0.152 mmol), DME (1.5 mL), Sodium carbonate (0.76 mL, 1.523 mmol) [2.0M (aq)] and PdCl2(dppf)-CH2Cl2 adduct (12.43 mg, 0.015 mmol). Vial capped and heated in an aluminum tray at 120 C for 3 hr. Reaction mixture was cooled to RT, diluted with water. Aqueous mixture was extracted with EtOAc. Organic phases combined, washed with brine, dried (Na2SO4), filtered and concentrated. Residue dissolved with DMSO and purified by RHPLC. Product fractions combined, frozen and lyophilized to afford a TFA salt of 7-(1H-benzo[d]imidazol-4-yl)-N-(3,4,5-trimethoxyphenyl) benzo[d]oxazol-2-amine (8.1 mg, 0.015 mmol, 9.93 % yield).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Bromo-2-(trifluoromethoxy)benzene, its application will become more common.

Reference:
Article; Costales, Abran; Mathur, Michelle; Ramurthy, Savithri; Lan, Jiong; Subramanian, Sharadha; Jain, Rama; Atallah, Gordana; Setti, Lina; Lindvall, Mika; Appleton, Brent A.; Ornelas, Elizabeth; Feucht, Paul; Warne, Bob; Doyle, Laura; Basham, Stephen E.; Aronchik, Ida; Jefferson, Anne B.; Shafer, Cynthia M.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 6; (2014); p. 1592 – 1596;,
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Some common heterocyclic compound, 589-10-6, name is (2-Bromoethoxy)benzene, molecular formula is C8H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 589-10-6

3)0.24 g (10 mmol) of sodium hydride and 15 ml of N, N-dimethylformamide were added to a 50 ml round bottom flask,Stirred at room temperature for 10 minutes,Another 2.5 g (10 mmol) of compound 2 was addedAnd 10 mmol of 2-phenoxybromoethane,And TLC detection to the end of the reaction,The reaction mixture was then poured into 500 ml of ice water, extracted three times with 100 ml of ethyl acetate,The organic phases are combined, the solvent is evaporated to dryness,The resulting residue was purified by silica gel column chromatography (V dichloromethane: V methanol = 100: 1)Compound 3 (2.3 g, yield 63%) was obtained.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 589-10-6, its application will become more common.

Reference:
Patent; Guangxi Normal University; Chen Zhenfeng; Liang Hong; Liu Yancheng; Lu Xing; Huang Kunyuan; (13 pag.)CN106478677; (2017); A;,
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Related Products of 5414-19-7, A common heterocyclic compound, 5414-19-7, name is 1-Bromo-2-(2-bromoethoxy)ethane, molecular formula is C4H8Br2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

The t-butyl ester from Part D (3 g, 6.2 mmol), N,N-Dimethylformamide (15 mL), K2CO3 (2.76 g, 20 mmol), 2-bromoethyl ether, Aldrich, (1.75 g, 7.6 mmol), and 18-Crown-6 (0.49 g, 1.86 mmol) were heated together at 65 C. under an N2 atmosphere overnight. An additional 1 g of K2CO3 (7.2 mmol) and 0.87 g of 2-bromoethyl ether (3.78 mmol) were added to the mixture, and it was again stirred overnight at 65 C. under an N2 atmosphere. The reaction mixture was cooled to ambient temperature, and then added to deionized water (75 mL) and ethyl acetate (200 mL). The layers were separated, and the aqueous layer was back-extracted with ethyl acetate (50 mL). The combined ethyl acetate layers were washed with 100 mL of each of a 1:1 mixture of deionized water:saturated NaCl(aq) and saturated NaCl(aq), dried over MgSO4, filtered, and concentrated in vacuo. Chromatography (on silica, ethyl acetate/hexanes) produced 1.76 g (51.24%) a t-butyl ester pyran in the form of a solid.

The synthetic route of 5414-19-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Barta, Thomas E.; Becker, Daniel P.; Bedell, Louis J.; Boehm, Terri L.; Brown, David L.; Carroll, Jeffery N.; Chen, Yiyuan; Fobian, Yvette M.; Freskos, John N.; Gasiecki, Alan F.; Grapperhaus, Margaret L.; Heintz, Robert M.; Hockerman, Susan L.; Kassab, Darren J.; Khanna, Ish K.; Kolodziej, Stephen A.; Massa, Mark A.; McDonald, Joseph J.; Mischke, Brent V.; Mischke, Deborah A.; Mullins, Patrick B.; Nagy, Mark A.; Norton, Monica B.; Rico, Joseph G.; Schmidt, Michelle A.; Stehle, Nathan W.; Talley, John J.; Vernier, William F.; Villamil, Clara I.; Wang, Lijuan J.; Wynn, Thomas A.; US2005/9838; (2005); A1;,
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Application of 452-08-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 452-08-4, name is 2-Bromo-4-fluoro-1-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 107 9-Fluoro-1,2-dihydro-2,2,4-trimethyl-5-coumarino[3,4-f]quinoline (Compound 207, structure 41 of Scheme XI, where R1 =H, R2 =F) 5-Fluoro-2-methoxyphenylboronic acid (structure 37 of Scheme XI; where R1 =H, R2 =F) In a 200-mL flask, a solution of 2-bromo-4-fluoroanisole (Aldrich: 4.00 mL, 30.8 mmol) in THF (50 mL) was cooled to -78 C. (CO2 /IPA). To this solution n-BuLi (Aldrich: 2.5M in hexanes; 12.4 mL, 31 mmol, 1.0 equivuiv) was added dropwise over a 30 min period. The reaction mixture was stirred at -78 C. for 60 min and treated with trimethylborate (Aldrich: 10.5 mL, 92.4 mmol, 3.0 equivuiv). The reaction mixture was allowed to slowly warm to rt, stirred overnight (12 h), and cooled to 0 C. (ice/H2 O). The solution was treated with 5% HCl until the pH reached 6. The reaction mixture was poured into sat’d NH4 C80 mL) and extracted with CH2 Cl2 (3*100 mL). The extracts were washed with sat’d NH4 Cl (1*80 mL), combined, dried (MgSO4), filtered through a pad of Celite, and concentrated to afford 4.90 g (94%) of a white semi-solid. Data for 5-fluoro-2-methoxyphenylboronic acid: 1 H NMR (400 MHz, acetone-d6): 7.47 (dd, J =8.8, 3.3, 1 H); 7.17 (m, 1 H); 7.05 (dd, J=9.0, 3.9, 1 H); 3.93 (s, 3 H).

The chemical industry reduces the impact on the environment during synthesis 2-Bromo-4-fluoro-1-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Ligand Pharmaceuticals Incorporated; US5696133; (1997); A;,
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Reference of 1462-37-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, This compound has unique chemical properties. The synthetic route is as follows.

To N-Boc-L-tyrosinemethyl ester 17 (2 g, 6.8 mmol) indry DMF (20 ml) was added 2 equiv. of 2-bromo-O-benzyl-ethanol (2.9 g, 13.6 mmol) along with 3 equiv. of K2CO3(2.8 g, 20.4 mmol) at room temperature for 1h gave the arylalkyl ether inquantitative yield. The reaction mixture was quenched with ice and extractedwith cold EtOAc (2 x 50 ml). The organic extracts were washed with cold brine(30 ml) and dried over anhydrous Na2SO4. The solvent wasremoved under reduced pressure. The resulting crude product was purified bysilica gel column chromatography using hexanes : EtOAc (9:1) as eluent to givethe 18 (2.5 g) in 87percent yield.1H NMR (CDCl3300 MHz): delta7.4-7.28 (m, 5H), 7.02 (d, J = 8.5 Hz, 2H), 6.85 (d, J = 8.5 Hz, 2H), 4.99-4.91 (m, 0.5H),4.13 (t, J = 4.5Hz, 2H), 3.82 (t, J = 5.1Hz, 2H), 3.7 (s, 3H), 3.1-3.0 (m,2H), 1.42 (s, 9H). 13C NMR (CDCl3, 75 MHz) :delta172.4, 157.8, 155.0, 137.9, 130.2, 128.3, 128.0, 127.7, 127.6, 114.6, 79.8,73.3, 68.4, 67.3, 54.4, 52.1, 37.3, 28.2.IR (KBr): upsilon 2977, 2933, 2873, 1740,1695, 1613, 1585, 1512, 1481, 1392, 1368, 1330, 1248, 1220, 1163, 1072, 963,861, 772, 699 cm-1HRMS (ESI) m/zcalcd for C24H31NO6: 430.2208, found: 430.2224[M+H]+.[alpha]D25: -9.0(c = 1.0, CHCl3).

The chemical industry reduces the impact on the environment during synthesis ((2-Bromoethoxy)methyl)benzene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Kumar, Harish; Reddy, A. Srinivas; Reddy, B.V. Subba; Tetrahedron Letters; vol. 55; 9; (2014); p. 1519 – 1522;,
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Application of 450-88-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 450-88-4, name is 1-Bromo-4-fluoro-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

Diisopropylamine (9.6 mL, 69 mmol) was dissolved in THF (100 mL) under nitrogen atmosphere. The solution was cooled to -78 C, and n-BuLi (21.6 mL, 2.5M in hexanes) was added over 10 mm. The resulting solution was stirred at -78 C for an additional 20 mm. Then, a solution of 1-bromo-4-fluoro-2-methoxybenzene (10 g, 49 mmol) in THF (20 mL) was added dropwise over 15 mm. The mixture was stirred at -78 C for 1 hour. DMF (4.2 mL, 54 mmol) was added dropwise over 5 mm, and the reaction mixture was stirred at -78 C for another 45 mm. Saturated aqueous NH4Cl (50 mL) was added, and the mixture was allowed to warm to room temperature and then diluted with Et20 (200 mL) and 2N HCl (100 mL). The organic layer was separated, and the aqueous layer was extracted with Et2O (2×50 mL). The combined organics were washed with brine (50 mL), dried (Na2SO4), concentrated in vacuo and purified by column chromatography on silica gel (1:50 EA/PE) to afford the title compound as a yellow solid (9.7 g). 1H NMR (400 MHz, CDCl3): oe 10.35 (s, 1H), 7.77-7.74 (m, 1H), 6.92-6.87 (m, 1H), 3.97 (s, 3H).

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-4-fluoro-2-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; SERAGON PHARMACEUTICALS, INC.; SMITH, Nicholas, D.; GOVEK, Steven, P.; KAHRAMAN, Mehmet; JULIEN, Jackaline, D.; NAGASAWA, Johnny, Y.; DOUGLAS, Karensa, L.; BONNEFOUS, Celine; LAI, Andiliy, G.; WO2013/142266; (2013); A1;,
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