Some common heterocyclic compound, 589-10-6, name is (2-Bromoethoxy)benzene, molecular formula is C8H9BrO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 589-10-6
3)0.24 g (10 mmol) of sodium hydride and 15 ml of N, N-dimethylformamide were added to a 50 ml round bottom flask,Stirred at room temperature for 10 minutes,Another 2.5 g (10 mmol) of compound 2 was addedAnd 10 mmol of 2-phenoxybromoethane,And TLC detection to the end of the reaction,The reaction mixture was then poured into 500 ml of ice water, extracted three times with 100 ml of ethyl acetate,The organic phases are combined, the solvent is evaporated to dryness,The resulting residue was purified by silica gel column chromatography (V dichloromethane: V methanol = 100: 1)Compound 3 (2.3 g, yield 63%) was obtained.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 589-10-6, its application will become more common.
Reference:
Patent; Guangxi Normal University; Chen Zhenfeng; Liang Hong; Liu Yancheng; Lu Xing; Huang Kunyuan; (13 pag.)CN106478677; (2017); A;,
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