Tag: M.W=200-300

Related Products of 202865-58-5,Some common heterocyclic compound, 202865-58-5, name is 1-Bromo-4,5-difluoro-2-methoxybenzene, molecular formula is C7H5BrF2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

1-bromo-4,5-difluoro-2-Methoxy – benzene (1.0g, 4.5mml), 4- (4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl) phenol (1.09g, 4.93mmol), PdCl2 (dppf) (328mg, 0.448mmol) and sodium carbonate (1.51g, 11.2mmol) of 1,4-dioxane and a mixed solution of water (40mL, v / v = 4/1) in addition, at 100 the mixture was stirred for 1 hour. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, and dried with anhydrous magnesium sulfate. After the solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel chromatography (hexane / ethyl acetate), to give the title compound. Yield: 1.13g (3.56mmol) Yield: 79%

The synthetic route of 202865-58-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; AJINOMOTO COMPANY INCORPORATED; MIYANAGA, WATARU; NAKAGAWA, TADAKIYO; DOHI, MIZUKI; MATSUMOTO, KAYO; TOKUMASU, MUNETAKA; TAKESHITA, SEN; (58 pag.)JP2016/13983; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 35202-55-2, name is (3,4-Dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methanamine hydrochloride, This compound has unique chemical properties. The synthetic route is as follows., category: ethers-buliding-blocks

1.5 mL of ethyl chloroformate are poured into a suspension of 3.4 g of the compound obtained in Step 1 in 4.5 mL of triethylamine and 50 mL of dichloromethane and left overnight, whilst stiffing at ambient temperature; washing with water and with 1N hydrochloric acid is then carried out. Drying is carried out and the solvent is evaporated off to dryness. 3.2 g of an oil corresponding to the expected product are obtained. [0046] Yield=80%

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 35202-55-2.

Reference:
Patent; LES LABORATOIRES SERVIER; CARRANZA, Maria Del Pilar; GARCIA ARANDA, Maria Isabel; GONZALEZ, Jose Lorenzo; SANCHEZ, Frederic; US2014/163220; (2014); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 866633-25-2, name is 2-Bromo-4-fluoro-1-(trifluoromethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows., COA of Formula: C7H3BrF4O

Preparation 18 r2-(Trifluoromethoxy)-5-fluorophenyllboronic acid A solution of isopropylmagnesium bromide (2M solution in tetrahydrofuran) (83 ml, 0.166 mol) was added drop-wise to a stirred solution of 2-(trifluoromethoxy)-5-fluoro- 1-bromobenzene (Preparation 17, 27.6 g, 0.107 mol) in anhydrous tetrahydrofuran (125 ml) at -1 O0C under an atmosphere of nitrogen. The resulting mixture was stirred at room temperature for 2 hours. Triisopropyl borate (26.1 g, 0.139 mol) was then added drop-wise at -100C and the resulting mixture was stirred at room temperature for 16 hours. Hydrochloric acid (1 N aqueous solution) (100 ml) was added drop-wise at O0C and the mixture stirred at room temperature for 30 minutes. Ethyl acetate (150 ml) was added and the layers were separated, the aqueous layer was further extracted with ethyl acetate (2 x 150 ml). The organic extracts were combined and concentrated in vacuo. The residue was dissolved in potassium hydroxide (10% aqueous solution) (50 ml) and extracted with diethyl ether (2 x 150 ml). The separated aqueous layer was acidified to pH~4 by addition of hydrochloric acid (1 N aqueous solution) (100 ml) and extracted with ethyl acetate (3 x 150 ml). The combined organic extracts were dried over anhydrous Na2SO4, filtered and evaporated in vacuo to give an off white solid. Purification by preparative HPLC gave the title compound as an off white solid (5.82 g, 24%).1HNMR (de-DMSO): 7.23-7.32 (m, 3H), 7.53-7.55 (m, 1 H), 8.36 (br s, 1 H).MS m/z 223 [MH]-

According to the analysis of related databases, 866633-25-2, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER LIMITED; WO2008/135830; (2008); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 1236000-51-3,Some common heterocyclic compound, 1236000-51-3, name is N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride, molecular formula is C9H11ClF3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Intermediate 29 5-bromo-N-methyI-N-({4-[(trifluoromethyl)oxy]phenyl}methyl)-1-benzothiophene-2-carboxamide. In a round bottom flask under argon atmosphere were placed 0.3 g of 5-bromo-1- benzothiophene-2-carboxylic acid, 0.459 g of TOTU (O-[(ethoxycarbonyl)cyanomethyl- enamino]-/V,/V,/V,/V-tetramethyluronium tetrafluoroborate) and 0.423 g of Intermediate 1 in12 ml of CH2CI2. The mixture was cooled to 0 0C and 0.49 ml of Et3N were added. The reaction mixture was stirred overnight at room temperature, then diluted with CH2CI2, washed with 1 N NaOH and brine, dried over Na2SO4, filtered and concentrated to dryness under vacuum. The residue was purified by chromatography on silica gel eluting withEtOAc-Hex 10:90 to 20:80 to afford 0.471 mg (91%) of the titled compound as a pale yellow oil.1H NMR (delta, ppm, DMSO-d6-80C): 8.11 (s, 1 H); 7.94 (d, 1 H); 7.73 (s, 1 H); 7.55 (dd, 1 H);7.42 (d, 2H); 7.33 (d, 2H); 4.75 (s, 2H); 3.12 (s, 3H). [ES MS] m/z: 445 (MH+).

The synthetic route of 1236000-51-3 has been constantly updated, and we look forward to future research findings.

Related Products of 1682-04-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1682-04-8, name is 1-Bromo-2,3,5,6-tetrafluoro-4-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

To a 200 mL flask which had been sufficiently dried under argon atmosphere, 30 mL of anhydrous pentane and 25.9 g (0.10 mol) of 4-bromo-2,3,5,6-tetrafluoroanisole were added and the mixture was cooled to -78 C. in a dry ice/acetone bath. Dropped thereto over 50 minutes was 61.2 mL of 1.6 mol/L n-butyl lithium hexane solution and the thus obtained mixture was subsequently stirred for 5 hours at -78 C. Thereto dropped over 30 minutes was 24.5 mL of 1 mol/L boron trichloride/hexane solution. The thus obtained reaction solution was stirred while being restored to room temperature, followed by further stirring for 12 hours after the reaction solution was restored to room temperature. To this reaction solution, 80 mL of water was slowly added to hydrolyze the reaction mixture and the formed crystals were collected, which were then washed with 80 mL of hexane and 80 mL of water to obtain 12.2 g of tetrakis(2,3,5,6-tetrafluoro-4-methoxyphenyl) lithium borate having an HPLC purity of 98.1% (Yield: 68%). The thus obtained product was subjected to measurements by 1H-NMR (heavy methanol solvent) and MALDI TOF-MS to confirm that it was the desired product.(0180)(Measurement Results)(0181)1H-NMR (shift; ppm: multiplicity: number of protons)(0182)(3.8: s: 12)(0183)MALDI TOF-MS (m/z)(0184)mass: 727.21 (Theoretical value: 727.19)

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2,3,5,6-tetrafluoro-4-methoxybenzene. I believe this compound will play a more active role in future production and life.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22807-80-3, name is 1-Bromo-4-(tert-butoxymethyl)benzene, A new synthetic method of this compound is introduced below., Computed Properties of C11H15BrO

(E)-N-(tert-butyl)-2-(4-bromophenyl)-2-oxoacetimidoyl cyanide employs the following steps:1 In a 1000 ml reactor, add 7.29 g of p-bromobenzyl tert-butyl ether, 13.60 ml of t-butyl isocyanide, 0.78 g of silver trifluoromethanesulfonate, and 13.60 g of 2,3-dichloro-5,6-dicyano -1,4-benzoquinone, 300 ml of chlorobenzene, heated to 80 C. The reaction is followed by thin layer chromatography until the reaction material disappears;2 After the reaction is completed, it is cooled to room temperature. The product was extracted with ethyl acetate and washed with saturated brine. After drying, the solvent was removed on a rotary evaporator to obtain a crude product;3 Crude product was purified by column chromatography (peel ether: ethyl acetate = 100:1) to afford 6.24 g of (E)-N-(t-butyl)-2-(4-bromophenyl)-2-oxo Iminoacetyl cyanide having a structural formula of 71%.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Application of 2982-54-9, These common heterocyclic compound, 2982-54-9, name is 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 4. Preparation of 3-((2-(4-benzyloxy-phenyl)-ethylamino)-methyl)-7-methyl-chromen-2-one: 7-Methyl-2-oxo-2H-chromen-3-carbaldehyde (380mg, 2.02mmol) (ScetharamaiyerPadmanabhan, Ravikumar Peri and David J. Triggle, Syn. Comm., 26(4), pp 827-831, 1996) and the compound (130mg, 0.40mmol) prepared in the step 3 were dissolved in dried THF (6ml) and methanol (12ml). thereto triethylamine (0.96ml, 6.87mmol) was added and the reaction mixture was stirred at room temperature for 3 hours. Thereafter, the temperature was lowered to O0C, and thereto acetic acid (0.41ml, 7.07mmol) and sodiumborohydride (0.178mg, 2.83mmol) were added, and the reaction mixture was stirred at O0C for 2 hours. Ice water (0.1ml) was added to quench the reaction, and aqueous layer was extracted with ethyl acetate. Combined organic layer was concentrated under reduced pressure. The residue was purified by column chromatography (n-hexane:ethyl acetate = 1:1) to give 240mg (yield: 29.1%, white solid) of the target compound. 1H-NMR (CDC13, 400MHz) delta 6.79-7.79(m, 13H), 5.05(s, 2H), 4.57(m, IH),2.78-3.54(m, 6H), 2.28(s, 3H)

Statistics shows that 2-(4-(Benzyloxy)phenyl)ethanamine hydrochloride is playing an increasingly important role. we look forward to future research findings about 2982-54-9.

Synthetic Route of 1049730-91-7,Some common heterocyclic compound, 1049730-91-7, name is 2-Bromo-4-methoxy-1-(trifluoromethoxy)benzene, molecular formula is C8H6BrF3O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 2-Bromo-4-methoxy-1-trifluoromethoxy-benzene (Preparation 59, 19.0 g, 73.9 mmol) in anhydrous tetrahydrofuran (400 ml) was added n-butyl lithium (2.5M solution in hexanes, 44.2 ml, 110.9 mmol) while maintaining the temperature below -7O0C under an atmosphere of nitrogen. The resulting solution was stirred at -7O0C for 1 hour. Tri-/sopropyl borate (20.9 g, 110.9 mmol) was added and the mixture stirred at -7O0C for an additional 2 hours. The reaction mixture was quenched with saturated ammonium chloride aqueous solution (400 ml). The resulting mixture was acidified to pH~5 by addition of hydrochloric acid (1 N aqueous solution). The layers were separated and the organic layer was washed with water (200 ml) then dried over anhydrous MgSO4 (s), filtered and evaporated in vacuo. Residue was purified by recrystallization from ethyl acetate: petroleum ether (2 ml:50 ml) to afford the title compound as a white solid (7.5 g, 43%).1HNMR (c^DMSO): 3.76 (s, 3H), 6.99 (dd, 1 H), 7.06 (d, 1 H), 7.18 (dd, 1 H), 8.36 (s, 2H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Bromo-4-methoxy-1-(trifluoromethoxy)benzene, its application will become more common.

Application of 35202-55-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 35202-55-2 as follows.

Step 2: ethyl (3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)carbamate 1.5 mL of ethyl chloroformate are poured into a suspension of 3.4 g of the compound obtained in Step 1 in 4.5 mL of triethylamine and 50 mL of dichloromethane and left overnight, whilst stiffing at ambient temperature; washing with water and with 1N hydrochloric acid is then carried out. Drying is carried out and the solvent is evaporated off to dryness. 3.2 g of an oil corresponding to the expected product are obtained. Yield=80%

According to the analysis of related databases, 35202-55-2, the application of this compound in the production field has become more and more popular.

Related Products of 954235-78-0, A common heterocyclic compound, 954235-78-0, name is 4-Bromo-2-(difluoromethoxy)-1-fluorobenzene, molecular formula is C7H4BrF3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-bromo-2-fluoro-1-difluoromethoxybenzene (1.0 g, 4.1 mmol),bis(pinacolato)diboron (1.3 g, 5.0 mmol), 1,1-bis(diphenylphosphino)ferrocene-palladium(II) dichloride dichloromethane complex (0.3 g, 0.4 mmol), KOAc (0.8 g, 8.3 mmol), and anhydrous 1,4-dioxane (8.3 mL) are added to a pressure vessel. Argon is bubbled through the solution for several minutes. The vessel is sealed and is heated at 85 C overnight. After cooling to RT, the reaction mixture is diluted with EtOAc and filtered through diatomaceous earth. The filtrate is concentrated to crude blackish oil under reduced pressure and is dissolved in acetone (14 mL). The resulting suspension is cooled to 0 C and a solution of potassium peroxymonosulfate (3.1 g, 5.0 mmol) in water (13.8 mL) is added over 10 min. After stirring for 2 h while maintaining the temperature at 0C, the reaction mixture is diluted with water (40 mL), and the mixture is extracted with EtOAc (3 x 40 mL). The resulting layers are separated, and the combined organic layers are washed with saturated aqueous NaCl, dried over Na2S04, filtered and concentrated under reduced pressure. The resulting residue is purified by silica gel flash column chromatography, using a gradient of 10-50% EtOAc in hexanes, to yield the title compound (0.77 g, quantitative yield) as a yellow oil. ES/MS m/z 176.8 [M-H].

The synthetic route of 954235-78-0 has been constantly updated, and we look forward to future research findings.