Application of 1236000-51-3,Some common heterocyclic compound, 1236000-51-3, name is N-Methyl-1-(4-(trifluoromethoxy)phenyl)methanamine hydrochloride, molecular formula is C9H11ClF3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Intermediate 29 5-bromo-N-methyI-N-({4-[(trifluoromethyl)oxy]phenyl}methyl)-1-benzothiophene-2-carboxamide. In a round bottom flask under argon atmosphere were placed 0.3 g of 5-bromo-1- benzothiophene-2-carboxylic acid, 0.459 g of TOTU (O-[(ethoxycarbonyl)cyanomethyl- enamino]-/V,/V,/V,/V-tetramethyluronium tetrafluoroborate) and 0.423 g of Intermediate 1 in12 ml of CH2CI2. The mixture was cooled to 0 0C and 0.49 ml of Et3N were added. The reaction mixture was stirred overnight at room temperature, then diluted with CH2CI2, washed with 1 N NaOH and brine, dried over Na2SO4, filtered and concentrated to dryness under vacuum. The residue was purified by chromatography on silica gel eluting withEtOAc-Hex 10:90 to 20:80 to afford 0.471 mg (91%) of the titled compound as a pale yellow oil.1H NMR (delta, ppm, DMSO-d6-80C): 8.11 (s, 1 H); 7.94 (d, 1 H); 7.73 (s, 1 H); 7.55 (dd, 1 H);7.42 (d, 2H); 7.33 (d, 2H); 4.75 (s, 2H); 3.12 (s, 3H). [ES MS] m/z: 445 (MH+).
The synthetic route of 1236000-51-3 has been constantly updated, and we look forward to future research findings.