Related Products of 202865-58-5,Some common heterocyclic compound, 202865-58-5, name is 1-Bromo-4,5-difluoro-2-methoxybenzene, molecular formula is C7H5BrF2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-bromo-4,5-difluoro-2-Methoxy – benzene (1.0g, 4.5mml), 4- (4,4,5,5- tetramethyl-1,3,2-dioxaborolan-2-yl) phenol (1.09g, 4.93mmol), PdCl2 (dppf) (328mg, 0.448mmol) and sodium carbonate (1.51g, 11.2mmol) of 1,4-dioxane and a mixed solution of water (40mL, v / v = 4/1) in addition, at 100 the mixture was stirred for 1 hour. The reaction mixture was diluted with ethyl acetate, washed with water and saturated brine, and dried with anhydrous magnesium sulfate. After the solvent was evaporated under reduced pressure, and the resulting residue was purified by silica gel chromatography (hexane / ethyl acetate), to give the title compound. Yield: 1.13g (3.56mmol) Yield: 79%
The synthetic route of 202865-58-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AJINOMOTO COMPANY INCORPORATED; MIYANAGA, WATARU; NAKAGAWA, TADAKIYO; DOHI, MIZUKI; MATSUMOTO, KAYO; TOKUMASU, MUNETAKA; TAKESHITA, SEN; (58 pag.)JP2016/13983; (2016); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem