Tag: M.W=250-300

Shimizu, Satoko published the artcileChemical factors underlying the more rapid β-O-4 bond cleavage of syringyl than guaiacyl lignin under alkaline delignification conditions, Formula: C16H18O4, the publication is Journal of Wood Chemistry and Technology (2017), 37(6), 451-466, database is CAplus.

This study aimed to clarify why the β-O-4 bond cleavage of syringyl lignin is more rapid than that of guaiacyl lignin under alk. pulping conditions. We examined whether or not three chem. factors, acidity of the α-hydroxy group, nucleophilicity of the generated α-alkoxide, and leaving ability of the leaving phenoxide, are different between syringyl and guaiacyl lignins and control the rate of the alk.-induced β-O-4 bond cleavage, employing dimeric non-phenolic β-O-4-type lignin model compounds (LMCs) and novel methods for estimating these three factors. The results indicated that the α-hydroxy groups of syringyl-type LMCs are relatively more acidic than those of guaiacyl-type and that syringyl nucleus is a better leaving group than guaiacyl nucleus in the β-O-4 bond cleavage. These factors result in the β-O-4 bond of syringyl lignin being more prone to the alk.-induced cleavage than that of guaiacyl lignin.

Journal of Wood Chemistry and Technology published new progress about 183303-74-4. 183303-74-4 belongs to ethers-buliding-blocks, auxiliary class Benzene,Alcohol,Ether, name is 1-(3,4-Dimethoxyphenyl)-2-phenoxyethanol, and the molecular formula is C4H5BN2O2, Formula: C16H18O4.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Landge, Shashikant B.; Dahale, Sunil B.; Jadhav, Sanjay A.; Solanki, Pavankumar V.; Bembalkar, Saroj R.; Mathad, Vijayavitthal T. published the artcile< Development and validation of stability indicating rapid RP-LC method for determination of process and degradation related impurities of apremilast, an anti-inflammatory drug>, COA of Formula: C12H19NO4S, the main research area is RPLC degradation apremilast antiinflammatory drug.

A new, specific, rapid and stability indicating reversed phase liquid chromatog. (RP-LC) method for the determination of process related and degradation related impurities of Apremilast has been developed and validated. The degradation study performed in acid, base, oxidative, photolytic, and thermal stressed conditions. Eight process related impurities (Imp-1 to Imp-8) in test sample of Apremilast have been detected by developed RP-LC method. The good chromatog. resolution between the peaks of process related impurities, degradation impurities and Apremilast has been achieved on a Synergi Max-RP 80 A (150 × 4.6 mm ID), 4μ column. The process and degradation related impurities were characterized by mass spectrometry, 1 H NMR and FT-IR spectral data. The method was validated as per ICH guideline and found to be specific, rapid, and stability indicating. The proposed RP-PLC method was successfully applied to the anal. of drug substance samples of Apremilast.

American Journal of Analytical Chemistry published new progress about Anti-inflammatory agents. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, COA of Formula: C12H19NO4S.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Qi, Li; Liu, Jian; Ronk, Michael; Gallegos, Alejandra; Fujimori, Kiyoshi; Luo, Yanxin; Li, Kim; Lee, Hans; Nashed-Samuel, Yasser published the artcile< A Holistic Approach of Extractables and Leachables Assessment of Rubber Stoppered Glass Vial Systems for Biotechnology Products>, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol, the main research area is rubber stoppered glass vial extractable leachable biotechnol; Extractables; Glass vials; Holistic approach; ICH Q3D; Leachables; Rubber stoppers; Toxicology.

Rubber stoppered glass vial systems are widely used as primary containers for storing and delivering therapeutic protein products to patients. Addressing concerns and regulatory expectations related to the risk to biol. drug product quality and patient safety from rubber stoppered glass vial systems requires implementation of an extractable and leachable evaluation program based on material understanding, risk assessment, literature review, and a comprehensive scientifically sound anal. testing methodol. The extractable and leachable study design consisted of twelve drug products filled in twelve different size glass vials capped with laminated and nonlaminated rubber stoppers made from three different rubber formulations. Design of the model solvents was successful as they had little to no anal. interference and mimicked the formulation conditions and generated representative extractables capable of predicting leachables. The extraction conditions of time and temperature were appropriate as not to degrade the test materials or the extractable compounds, and yet generated significant quantities for identification of the extractable compounds with confidence. The extractables testing results were capable of predicting the leachable profiles of the twelve drug products. In each case, the leachable profile was a subset of the extractable profile. The organic and elemental impurities of the leachable profiles of drug products were the end-to-end verification of the quality of the glass vials, rubber stoppers and drug product lifecycles. Overall, the holistic approach was fully successful in the qualification of different vial systems as primary containers and delivery systems for different biotherapeutic products to ensure product quality and patient safety.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Bioavailability. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Qi, Li; Liu, Jian; Ronk, Michael; Gallegos, Alejandra; Fujimori, Kiyoshi; Luo, Yanxin; Li, Kim; Lee, Hans; Nashed-Samuel, Yasser published the artcile< A Holistic Approach of Extractables and Leachables Assessment of Rubber Stoppered Glass Vial Systems for Biotechnology Products>, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol, the main research area is rubber stoppered glass vial extractable leachable biotechnol; Extractables; Glass vials; Holistic approach; ICH Q3D; Leachables; Rubber stoppers; Toxicology.

Rubber stoppered glass vial systems are widely used as primary containers for storing and delivering therapeutic protein products to patients. Addressing concerns and regulatory expectations related to the risk to biol. drug product quality and patient safety from rubber stoppered glass vial systems requires implementation of an extractable and leachable evaluation program based on material understanding, risk assessment, literature review, and a comprehensive scientifically sound anal. testing methodol. The extractable and leachable study design consisted of twelve drug products filled in twelve different size glass vials capped with laminated and nonlaminated rubber stoppers made from three different rubber formulations. Design of the model solvents was successful as they had little to no anal. interference and mimicked the formulation conditions and generated representative extractables capable of predicting leachables. The extraction conditions of time and temperature were appropriate as not to degrade the test materials or the extractable compounds, and yet generated significant quantities for identification of the extractable compounds with confidence. The extractables testing results were capable of predicting the leachable profiles of the twelve drug products. In each case, the leachable profile was a subset of the extractable profile. The organic and elemental impurities of the leachable profiles of drug products were the end-to-end verification of the quality of the glass vials, rubber stoppers and drug product lifecycles. Overall, the holistic approach was fully successful in the qualification of different vial systems as primary containers and delivery systems for different biotherapeutic products to ensure product quality and patient safety.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Bioavailability. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Recommanded Product: 2,2′-(Tridecylazanediyl)diethanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ruchelman, Alexander L.; Connolly, Terrence J. published the artcile< Enantioselective synthesis of the apremilast aminosulfone using catalytic asymmetric hydrogenation>, COA of Formula: C12H19NO4S, the main research area is enantioselective apremilast aminosulfone catalytic asym hydrogenation.

Celgene’s Otezla (apremilast) is the first and only PDE4 inhibitor approved by the US FDA for the treatment of plaque psoriasis and psoriatic arthritis. Apremilast has been historically prepared via resolution to obtain the enantioenriched aminosulfone intermediate. Herein we have investigated the use of catalytic asym. hydrogenation for the enantioselective synthesis of the key aminosulfone intermediate in order to identify a higher yielding and greener synthesis route. Asym. reduction of the enamine 3-EtO-4-MeOC6H3C(NH2):CHSO2Me and the ketone 3-EtO-4-MeOC6H3COCH2SO2Me both proceeded with high selectivities, generating their resp. products with >95% ee.

Tetrahedron: Asymmetry published new progress about Enantioselective synthesis. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, COA of Formula: C12H19NO4S.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yan, Jincan; Zeng, Xiangqiong; van der Heide, Emile; Ren, Tianhui published the artcile< The tribological performance and tribochemical analysis of novel borate esters as lubricant additives in rapeseed oil>, Formula: C17H37NO2, the main research area is rapeseed oil lubricant additive borate ester tribofilm XANES XPS.

Two novel borate esters, tris (4-dodecylphenyl) borate and 2-(2-(4-dodecylphenoxy)-1, 3, 6, 2-dioxazaborocan-6-yl) ethanol were synthesized and applied as anti-wear and extreme pressure additives in rapeseed oil. The borate esters possess high anti-wear and extreme pressure properties. XANES and XPS were used to analyze the composition and structure of boundary films at the worn surfaces. It is shown that the additives form a protective film at the rubbed surfaces based on B2O3 and/or BN. B-N synergetic effect was found in the results which suggests that tribofilms composed of BN are to be preferred over tribofilms that consists of B2O3.

Tribology International published new progress about Friction. 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Formula: C17H37NO2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Davidescu, C. M.; Popa, A. published the artcile< Quaternary ammonium salts grafted on gel-type styrene-divinylbenzene copolymers>, Reference of 18312-57-7, the main research area is styrene divinylbenzene copolymer chloromethylated amine quaternization; quaternary ammonium salt styrene divinylbenzene copolymer.

Polymer-grafted quaternary ammonium salts were prepared by polymer-analogous direct quaternization of chloromethylated styrene-7% divinylbenzene copolymers. More simpler procedures for the calculation of the functionalization degrees and the statistical modeling of the structural repetitive unit of the copolymer are reported.

Buletinul Stiintific al Universitatii “Politehnica” din Timisoara Romania, Seria Chimie Industriala si Ingineria Mediului published new progress about Quaternary ammonium compounds, polymers Role: SPN (Synthetic Preparation), PREP (Preparation). 18312-57-7 belongs to class ethers-buliding-blocks, and the molecular formula is C17H37NO2, Reference of 18312-57-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Man, Hon-Wah; Schafer, Peter; Wong, Lu Min; Patterson, Rebecca T.; Corral, Laura G.; Raymon, Heather; Blease, Kate; Leisten, Jim; Shirley, Michael A.; Tang, Yang; Babusis, Darius M.; Chen, Roger; Stirling, Dave; Muller, George W. published the artcile< Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor>, HPLC of Formula: 608141-42-0, the main research area is apremilast acetylamino analog preparation PDE4 TNF inhibitor structure antiinflammatory.

In this communication, we report the discovery of 1S (apremilast), a novel potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α inhibitor. The optimization of previously reported 3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-3-(3,4-dimethoxyphenyl)propionic acid PDE4 inhibitors led to this series of sulfone analogs. Evaluation of the structure-activity relationship of substitutions on the phthalimide group led to the discovery of an acetylamino analog 1S, which is currently in clin. trials.

Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, HPLC of Formula: 608141-42-0.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem