Man, Hon-Wah; Schafer, Peter; Wong, Lu Min; Patterson, Rebecca T.; Corral, Laura G.; Raymon, Heather; Blease, Kate; Leisten, Jim; Shirley, Michael A.; Tang, Yang; Babusis, Darius M.; Chen, Roger; Stirling, Dave; Muller, George W. published the artcile< Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor>, HPLC of Formula: 608141-42-0, the main research area is apremilast acetylamino analog preparation PDE4 TNF inhibitor structure antiinflammatory.
In this communication, we report the discovery of 1S (apremilast), a novel potent and orally active phosphodiesterase 4 (PDE4) and tumor necrosis factor-α inhibitor. The optimization of previously reported 3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)-3-(3,4-dimethoxyphenyl)propionic acid PDE4 inhibitors led to this series of sulfone analogs. Evaluation of the structure-activity relationship of substitutions on the phthalimide group led to the discovery of an acetylamino analog 1S, which is currently in clin. trials.
Journal of Medicinal Chemistry published new progress about Anti-inflammatory agents. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, HPLC of Formula: 608141-42-0.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem