Landge, Shashikant B.; Dahale, Sunil B.; Jadhav, Sanjay A.; Solanki, Pavankumar V.; Bembalkar, Saroj R.; Mathad, Vijayavitthal T. published the artcile< Development and validation of stability indicating rapid RP-LC method for determination of process and degradation related impurities of apremilast, an anti-inflammatory drug>, COA of Formula: C12H19NO4S, the main research area is RPLC degradation apremilast antiinflammatory drug.
A new, specific, rapid and stability indicating reversed phase liquid chromatog. (RP-LC) method for the determination of process related and degradation related impurities of Apremilast has been developed and validated. The degradation study performed in acid, base, oxidative, photolytic, and thermal stressed conditions. Eight process related impurities (Imp-1 to Imp-8) in test sample of Apremilast have been detected by developed RP-LC method. The good chromatog. resolution between the peaks of process related impurities, degradation impurities and Apremilast has been achieved on a Synergi Max-RP 80 A (150 × 4.6 mm ID), 4μ column. The process and degradation related impurities were characterized by mass spectrometry, 1 H NMR and FT-IR spectral data. The method was validated as per ICH guideline and found to be specific, rapid, and stability indicating. The proposed RP-PLC method was successfully applied to the anal. of drug substance samples of Apremilast.
American Journal of Analytical Chemistry published new progress about Anti-inflammatory agents. 608141-42-0 belongs to class ethers-buliding-blocks, and the molecular formula is C12H19NO4S, COA of Formula: C12H19NO4S.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem