Fanourakis, Alexander; Williams, Benjamin D.; Paterson, Kieran J.; Phipps, Robert J. published the artcile< Enantioselective Intermolecular C-H Amination Directed by a Chiral Cation>, Product Details of C11H16O2, the main research area is heptafluorobutyl hydroxy butyl sulfamate preparation enantioselective; arylbutanol heptafluorobutyl sulfamate intermol amination rhodium catalyst.
A family of anionic variants of the best-in-class catalyst for Rh-catalyzed C-H amination, Rh2(esp)2, with which the chiral cations are associated And derived from quaternized cinchona alkaloids, has been described. These ion-paired catalysts enable high levels of enantioselectivity to be achieved in the benzylic C-H amination of substrates R(CH2)4OH (R = Ph, 1-naphthyl, 3-methylthiophen-2-yl, etc.) bearing pentyl hydroxyl groups. Addnl., the quinoline of the chiral cation appears to engage in axial ligation to the rhodium complex, providing improved yields of products RCH(NHS(O)2OCH2R1)(CH2)3OH (R1 = (CF2)2CF3) vs. Rh2(esp)2 and highlighting the dual role that the cation is playing. These results underline the potential of using chiral cations to control enantioselectivity in challenging transition-metal-catalyzed transformations.
Journal of the American Chemical Society published new progress about Amination catalysts (intermol., stereoselective). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem