Dupuy, Stephanie; Zhang, Ke-Feng; Goutierre, Anne-Sophie; Baudoin, Olivier published the artcile< Terminal-Selective Functionalization of Alkyl Chains by Regioconvergent Cross-Coupling>, Formula: C11H16O2, the main research area is aryl triflate alkyl bromide palladium zinc Barbier Negishi coupling; alkyl linear arene preparation; C−C coupling; alkyl bromides; homogeneous catalysis; palladium; remote functionalization.
Hydrocarbons are still the most important precursors of functionalized organic mols., which has stirred interest in the discovery of new C-H bond functionalization methods. We describe herein a new step-economical approach that enables C-C bonds to be constructed at the terminal position of linear alkanes. First, we show that secondary alkyl bromides can undergo in situ conversion into alkyl zinc bromides and regioconvergent Negishi coupling with aryl or alkenyl triflates. The use of a suitable phosphine ligand favoring Pd migration enabled the selective formation of the linear cross-coupling product. Subsequently, mixtures of secondary alkyl bromides were prepared from linear alkanes by standard bromination, and regioconvergent cross-coupling then provided access to the corresponding linear arylation product in only two steps.
Angewandte Chemie, International Edition published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Formula: C11H16O2.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem