Month: October 2022

Fang, Shengyang’s team published research in Advanced Synthesis & Catalysis in 2019 | CAS: 10365-98-7

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

The author of 《Nickel-Catalyzed Construction of 2,4-disubstituted Imidazoles via C-C Coupling and C-N Condensation Cascade Reactions》 were Fang, Shengyang; Yu, Haihua; Yang, Xicheng; Li, Jianqi; Shao, Liming. And the article was published in Advanced Synthesis & Catalysis in 2019. Synthetic Route of C7H9BO3 The author mentioned the following in the article:

A convenient Ni(II)-catalyzed C-C and C-N cascade coupling reaction was developed to directly access various 2,4-disubstituted imidazoles [e.g., N-(cyanomethyl)acetamide + phenylboronic acid → 2-methyl-4-phenyl-1H-imidazole (87%)]. The reaction scope covers a variety of aryl and aliphatic substitutions, which demonstrate moderate-to-excellent yields. The tolerance of halogen and N-containing heterocyclic groups demonstrates the versatility of this method for further synthetic explorations. The experimental part of the paper was very detailed, including the reaction process of 3-Methoxyphenylboronic acid(cas: 10365-98-7Synthetic Route of C7H9BO3)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Synthetic Route of C7H9BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zeng, Wulan’s team published research in Journal of Chemical Crystallography in 2019 | CAS: 4637-24-5

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C5H13NO2

The author of 《Crystal Structures of Spiro Derivatives Including 6,10-Dioxaspiro[4.5]decane-7,9-dione Group and Their Spectral Studies》 were Zeng, Wulan; Wang, Xia. And the article was published in Journal of Chemical Crystallography in 2019. Formula: C5H13NO2 The author mentioned the following in the article:

A new intermediate, I (C22H30N2O8) was attained by reaction of 6,10-dioxaspiro[4.5]decane-7,9-dione with 1,1-dimethoxy-n,n-dimethyl-methanamine in ethanol. The two oxaspirocyclic compounds, 8-[[(2-methylphenyl)amino]methylene]-6,10-dioxaspiro[4.5]decane-7,9-dione (2-C16H17NO4) and 8-[[(2-methylphenyl)amino]methylene]-6,10-dioxaspiro[4.5]decane-7,9-dione (3-C16H17NO4) were prepared by adding 2-methylbenzenamine and 3-methylbenzenamine into to the ethanol solution of I, resp. Two crystals (I and C16H17NO4 ) were determined by single-crystal X-ray diffraction. The compound of I includes one (C5H13N2)+ cation and one (C17H17O8)- anion, which indicates it is a salt. There is no classical hydrogen bonds in I. However, there is one kind of N-H···O intramol. interactions and one kind of C-H···O intermol. interactions in (2-C16H17NO4). In addition, the fluorescence spectra of 2-C16H17NO4 and 3-C16H17NO4 in dilute ethanol were studied, which they exhibit purplish red emission and reddish purple emission, resp. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Jia-Xin’s team published research in Inorganic Chemistry Communications in 2019 | CAS: 10365-98-7

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.COA of Formula: C7H9BO3

The author of 《Palladium nanoparticles encapsulated in MIL-101-NH2 catalyzed one-pot reaction of Suzuki-Knoevenagel reaction》 were Li, Jia-Xin; Li, Xin; Tang, Hong; Zhang, Yu-Yang; Han, Zheng-Bo. And the article was published in Inorganic Chemistry Communications in 2019. COA of Formula: C7H9BO3 The author mentioned the following in the article:

Bifunctional Cr-MOF catalysts containing palladium nanoparticles (NPs) have been prepared Combining the high activity of Pd NPs and base sites in MIL-101-NH2, the catalysts (Pd@MIL-101-NH2) exhibited distinct catalytic activity in a one-pot Suzuki-Knoevenagel reaction. Pd@MIL-101-NH2 has been characterized by x-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric anal. (TGA), and fourier transform IR spectroscopy (FT-IR). Various substituted phenylboronic acids were used to research the one-pot reaction. The results were highly satisfactory, not only got high yield, but reduced reaction time. Leakage experiments further demonstrated that there is no leaching of active palladium nanoparticles during the reactions. Catalysts could be reused for at least five cycles and activity is not significantly decreased.3-Methoxyphenylboronic acid(cas: 10365-98-7COA of Formula: C7H9BO3) was used in this study.

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.COA of Formula: C7H9BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Sabyuk’s team published research in Asian Journal of Organic Chemistry in 2020 | CAS: 2398-37-0

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Computed Properties of C7H7BrO

《Palladium-Catalyzed Direct C-H Arylation of Arenes Promoted by Quaternary Ammonium Salt》 was published in Asian Journal of Organic Chemistry in 2020. These research results belong to Yang, Sabyuk; Hong, Soon Hyeok. Computed Properties of C7H7BrO The article mentions the following:

A new Pd-based catalytic system for the direct C-H arylation of arenes was developed. The use of a substoichiometric amount of quaternary ammonium salt as an additive with a Pd source achieved the direct arylation of unactivated arenes under milder reaction conditions in moderate to high yields. The ammonium salt generated the anionic palladium complex, thereby facilitating arylation by a concerted metalation-deprotonation process. In the experiment, the researchers used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Computed Properties of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Computed Properties of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Peng, Kang’s team published research in European Journal of Organic Chemistry in 2020 | CAS: 529-28-2

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Electric Literature of C7H7IO

《Copper/Nickel-Catalyzed Selective C-S/S-S Bond Formation Starting from O-Alkyl Phenylcarbamothioates》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Peng, Kang; Gao, Ming-Yuan; Yi, Yu-Yan; Guo, Jia; Dong, Zhi-Bing. Electric Literature of C7H7IO The article mentions the following:

A convenient and effective method is described to construct C-S/S-S bond starting from O-alkyl phenylcarbamothioates, giving diverse O-alkyl S-Ph phenylcarbonimidothioates and isothiourea disulfides, resp. The C-S bond formation products (O-alkyl S-Ph phenylcarbonimidothioates) were synthesized by using Cu2O as catalyst in water (without phase-transfer catalyst), and the S-S bond formation product (isothiourea disulfides) could be furnished catalyzed by NiBr2 at room temperature These transformations feature easy control, environmental friendliness, and good to excellent yields, which could be attractive in the selective C-S/S-S bond formation.1-Iodo-2-methoxybenzene(cas: 529-28-2Electric Literature of C7H7IO) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Electric Literature of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Kangkang’s team published research in ChemCatChem in 2022-06-08 | 10541-78-3

ChemCatChem published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Li, Kangkang; Li, Jin-Feng; Yin, Bing; Zeng, Fanlong published the artcile< Investigation of NNN Pincer Ruthenium(II) Complexes with a Pendant Hydroxyl Group for N-Monomethylation of amines and Nitroarenes by Methanol>, Application In Synthesis of 10541-78-3, the main research area is hydroxy trinitrogen NNN pincer ruthenium preparation crystal mol structure; monomethylation amine nitroarene methanol hydroxy trinitrogen pincer ruthenium catalyzed.

A family of air- and moisture-stable NNN pincer ruthenium(II) complexes with a pendant OH were developed, which exhibit unprecedented high reactivity and selectivity in N-monomethylation of amines and nitroarenes using methanol. The study reveals adopting the combination of 1H-pyrazole-1-yl and 3,5-dimethyl-4-hydroxyethyl-1H-pyrazol-1-yl as the two assistant arms of the pyridyl-backbone is a suitable choice. The mechanism study discloses that, during the catalytic cycle, dehydrogenation of methanol to form formaldehyde is a fast and reversible step.

ChemCatChem published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Plamondon, Samuel J’s team published research in Angewandte Chemie, International Edition in 2020 | 56724-03-9

Angewandte Chemie, International Edition published new progress about Bicyclization. 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, Product Details of C9H10O2.

Plamondon, Samuel J.; Warnica, Josephine M.; Kaldre, Dainis; Gleason, James L. published the artcile< Hydrazide-Catalyzed Polyene Cyclization: Asymmetric Organocatalytic Synthesis of cis-Decalins>, Product Details of C9H10O2, the main research area is hydrazide polyene enantioselective diastereoselective cyclization catalyst; decalin stereoselective preparation; asymmetric catalysis; cis-decalin; hydrazide; organocatalysis; polyene cyclization.

Polyene cyclizations offer rapid entry into terpenoid ring systems. Although enantioselective cyclizations of (E)-polyenes to form trans-decalin ring systems are well precedented, highly enantioselective cyclizations of (Z)-polyenes to form the corresponding cis-decalins have not been reported. Here, we describe the first application of iminium catalysis to the initiation of polyene cyclizations. Et 1,2-diazepane-1-carboxylate catalyzes the cyclization of polyenes bearing enal initiators. Moreover, chiral bicyclic hydrazides catalyze the cyclizations of (Z)-polyene substrates to form cis-decalins with enantioselectivities of up to 97:3 er. DFT calculations suggest the catalysts promote the reaction by stabilizing pos. charge as it develops during the bicyclization.

Angewandte Chemie, International Edition published new progress about Bicyclization. 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, Product Details of C9H10O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Hui’s team published research in ACS Applied Energy Materials in 2021-01-25 | 6482-24-2

ACS Applied Energy Materials published new progress about Battery cathodes. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Application In Synthesis of 6482-24-2.

Chen, Hui; Niu, Zhihui; Ye, Jing; Zhang, Changkun; Zhang, Xiaohong; Zhao, Yu published the artcile< Multicore Ferrocene Derivative as a Highly Soluble Cathode Material for Nonaqueous Redox Flow Batteries>, Application In Synthesis of 6482-24-2, the main research area is redox flow battery ferrocene derivative cathode.

Nonaqueous redox flow batteries (NARFBs) are considered promising electrochem. energy storage systems to overcome the limited electrochem. window of aqueous counterparts. However, the limited solubility of redox-active materials in the nonaqueous phase, for instance, the intensively investigated ferrocene derivatives, needs to be addressed prior to their practical implementation. In this study, we demonstrate the design and synthesis of a multicore ferrocene derivative, 4,4-diferrocenyl-1-(2-methoxy-ethoxy)-pentane (DFDE), as a highly soluble cathode-active material for NARFBs. Owing to the tailored ether chain as well as the synergistic effect of multiple ferrocene cores, DFDE exhibits a high solubility of 4.5 M equivalent electron concentration in an ether-based solvent as well as a more pos. redox potential compared with pristine ferrocene, which are essential to improve the energy d. of NARFBs. Moreover, electrochem. characterizations reveal that DFDE undergoes highly reversible redox reactions with a fast electron-transfer rate constant When paired with N-butyl-phthalimide (BuPh), the cell exhibits a discharge voltage of ca. 1.8 V and stable cycling performance. The use of multicore ferrocene derivatives might represent an effective yet to be explored strategy to overcome the solubility limit of ferrocene-based cathode materials at affordable environmental and ecol. load.

ACS Applied Energy Materials published new progress about Battery cathodes. 6482-24-2 belongs to class ethers-buliding-blocks, and the molecular formula is C3H7BrO, Application In Synthesis of 6482-24-2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jeon, Heechol’s team published research in European Journal of Medicinal Chemistry in 2007-03-31 | 10305-42-7

European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Computed Properties of 10305-42-7.

Jeon, Heechol; Jo, Nam Hyun; Yoo, Kyung Ho; Choi, Joung-Hoon; Cho, Heeyeong; Cho, Jung-Hyuck; Oh, Chang-Hyun published the artcile< Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds>, Computed Properties of 10305-42-7, the main research area is carbapenem sulfonamide pyrrolidinyl preparation antibacterial structure activity relationship.

The synthesis of a new series of 1β-methylcarbapenems, I (R = SO2Me, SO2Et, SO2NHEt, SO2NMe2, SO2NH-n-Pr, COMe, H, CONH2) having methoxyimine and substituted sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-pos. and Gram-neg. bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound I (R = SO2NHMe) having (methylamino)sulfonamide moiety showed the most potent antibacterial activity.

European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Computed Properties of 10305-42-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Beke, Ferenc’s team published research in Nature Communications in 2020-12-31 | 10541-78-3

Nature Communications published new progress about Amination, regioselective. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Beke, Ferenc; Meszaros, Adam; Toth, Agnes; Botlik, Bence Bela; Novak, Zoltan published the artcile< Vicinal difunctionalization of carbon-carbon double bond for the platform synthesis of trifluoroalkyl amines>, Application In Synthesis of 10541-78-3, the main research area is trifluoroalkyl amine preparation regioselective; amine trifluoroalkenyl iodonium salt three component diamination.

Herein, the controllable double nucleophilic functionalization of an activated alkene synthon I, originated from a trifluoropropenyliodonium salt with two distinct nucleophiles, enables the selective synthesis of trifluoromethylated ethylene amines and diamines RCH(CF3)CH2R1 (R = methyl(naphthalen-1-ylmethyl)aminyl, methyl(prop-2-yn-1-yl)aminyl, 3-azabicyclo[3.2.2]nonan-3-yl, etc.; R1 = {1-[(tert-butoxy)carbonyl]azetidin-3-yl}(2-phenylethyl)aminyl, 2-sulfanylidene-1,2-dihydropyridin-1-yl, etc.) on broad scale with high efficiency under mild reaction conditions. Considering the chem. nature of the reactants, this synthetic approach brings forth an efficient methodol. and provides versatile access to highly fluorinated amines.

Nature Communications published new progress about Amination, regioselective. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem