Jeon, Heechol; Jo, Nam Hyun; Yoo, Kyung Ho; Choi, Joung-Hoon; Cho, Heeyeong; Cho, Jung-Hyuck; Oh, Chang-Hyun published the artcile< Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds>, Computed Properties of 10305-42-7, the main research area is carbapenem sulfonamide pyrrolidinyl preparation antibacterial structure activity relationship.
The synthesis of a new series of 1β-methylcarbapenems, I (R = SO2Me, SO2Et, SO2NHEt, SO2NMe2, SO2NH-n-Pr, COMe, H, CONH2) having methoxyimine and substituted sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-pos. and Gram-neg. bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound I (R = SO2NHMe) having (methylamino)sulfonamide moiety showed the most potent antibacterial activity.
European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Computed Properties of 10305-42-7.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem