Beke, Ferenc; Meszaros, Adam; Toth, Agnes; Botlik, Bence Bela; Novak, Zoltan published the artcile< Vicinal difunctionalization of carbon-carbon double bond for the platform synthesis of trifluoroalkyl amines>, Application In Synthesis of 10541-78-3, the main research area is trifluoroalkyl amine preparation regioselective; amine trifluoroalkenyl iodonium salt three component diamination.
Herein, the controllable double nucleophilic functionalization of an activated alkene synthon I, originated from a trifluoropropenyliodonium salt with two distinct nucleophiles, enables the selective synthesis of trifluoromethylated ethylene amines and diamines RCH(CF3)CH2R1 (R = methyl(naphthalen-1-ylmethyl)aminyl, methyl(prop-2-yn-1-yl)aminyl, 3-azabicyclo[3.2.2]nonan-3-yl, etc.; R1 = {1-[(tert-butoxy)carbonyl]azetidin-3-yl}(2-phenylethyl)aminyl, 2-sulfanylidene-1,2-dihydropyridin-1-yl, etc.) on broad scale with high efficiency under mild reaction conditions. Considering the chem. nature of the reactants, this synthetic approach brings forth an efficient methodol. and provides versatile access to highly fluorinated amines.
Nature Communications published new progress about Amination, regioselective. 10541-78-3 belongs to class ethers-buliding-blocks, and the molecular formula is C8H11NO, Application In Synthesis of 10541-78-3.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem