Month: October 2022

Formula: C10H20O5In 2020 ,《Facilitate Gas Transport through Metal-Organic Polyhedra Constructed Porous Liquid Membrane》 appeared in Small. The author of the article were Deng, Zheng; Ying, Wen; Gong, Ke; Zeng, Yu-Jia; Yan, Youguo; Peng, Xinsheng. The article conveys some information:

Type II porous liquids are demonstrated to be promise porous materials. However, the category of porous hosts is very limited. Here, a porous host metal-organic polyhedra (MOP-18) is reported to construct type II porous liquids MOP-18 is dissolved into 15-crown-5 as an individual cage (5 nm). Both the mol. dynamics simulations and exptl. gravimetric CO2 solubility test indicate that the inner cavity of MOP-18 in porous liquids is unoccupied by 15-crown-5 and is accessible to CO2. Thus, the prepared porous liquids show enhanced gas solubility Furthermore, the prepared porous liquid is encapsulated into graphene oxide (GO) nanoslits to form a GO-supported porous liquid membrane (GO-SPLM). Owing to the empty cavity of MOP-18 unit cages in porous liquids that reduces the gas diffusion barrier, GO-SPLM significantly enhances the permeability of gas. After reading the article, we found that the author used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Formula: C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Formula: C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C12H10S2In 2021 ,《Green Aerobic Oxidation of Thiols to Disulfides by Flavin-Iodine Coupled Organocatalysis》 was published in Synlett. The article was written by Oka, Marina; Kozako, Ryo; Iida, Hiroki. The article contains the following contents:

Coupled catalysis using a riboflavin-derived organocatalyst and mol. iodine successfully promoted the aerobic oxidation of thiols to disulfides under metal-free mild conditions. The activation of mol. oxygen occurred smoothly at room temperature through the transfer of electrons from the iodine catalyst to the biomimetic flavin catalyst, forming the basis for a green oxidative synthesis of disulfides from thiols. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Formula: C12H10S2) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Formula: C12H10S2 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sau, Miriam; Pericas, Miquel A.; Martin, Ruben published an article in 2022. The article was titled 《Pd-Catalyzed Arylation of 1,2-Amino Alcohol Derivatives via β-Carbon Elimination》, and you may find the article in Synlett.COA of Formula: C7H7BrO The information in the text is summarized as follows:

Herein, authors describe a Pd-catalyzed arylation of 1,2-amino alcs. with aryl halides enabled by a retroallylation manifold. This protocol constitutes a new entry point to β-arylated aldehydes via the intermediacy of in situ generated enamine intermediates. The protocol is characterized by its exquisite regioselectivity profile and broad substrate scope – including challenging substrate combinations – even in an enantioselective manner. In the experiment, the researchers used 1-Bromo-3-methoxybenzene(cas: 2398-37-0COA of Formula: C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.COA of Formula: C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Formula: C5H13NO2In 2021 ,《New and practical synthesis of GS-441524, the key intermediate of remdesivir》 appeared in Heterocycles. The author of the article were Li, Bo; Wang, Han; Sun, Cong; Lu, Sheng; Kang, LinLin; Jiang, Shun. The article conveys some information:

A new and practical synthesis of GS-441524, the key intermediate for remdesivir, is developed. 4-Amino-7-iodopyrrolo[2,1-f][1,2,4]triazine is protected by DMF-DMA, and reacted with 2,3,5-tri-O-benzyl-D-ribonolactone to give the product in 61% isolated yield. The next cyanation and debenzylation are carried out at -30° successively in 67% yield over two steps with >99% purity (HPLC). Purification methods of the intermediates and the final product involved in the route are developed. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Synlett included an article by Ni, Bang-qing; He, Yunpeng; Rong, Xuejiao; Niu, Teng-fei. Reference of 1,2-Diphenyldisulfane. The article was titled 《Molecular Iodine Catalyzed Hydroxysulfenylation of Alkenes with Disulfides in Aerobic Conditions》. The information in the text is summarized as follows:

An environmentally friendly and efficient strategy was developed for preparation β-hydroxy sulfides such as, R1C6H4SCHR2CR3R4OH [R1C6H4 = H, 4-Cl, 4-Me, etc.; R2 = H, Me, Ph; R3 = Ph, 4-BrC6H4, 2-naphthalenyl, etc.; R4 = H, Me, Ph] by a mol.-iodine-catalyzed radical reaction. This reaction involved hydroxysulfenylation of alkenes with disulfides in aqueous solution Air was used as the oxidant without any additives. Control experiments indicated that the oxygen atom of products might come from O2. Both aryl alkenes and aliphatic alkenes were well tolerated in this transformation and afforded the corresponding products in moderate to high yields. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7Reference of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Reference of 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,IUCrData included an article by Ramesh, V.; Rajarajan, K.; Gunasekaran, B.. Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane. The article was titled 《Bis(15-crown-5-κ5O)barium tetrakis(isothiocynato-κN)zinc(II)》. The information in the text is summarized as follows:

In the title compound, [Ba(C10H20O5)2][Zn(NCS)4], the 15-crown-5 mols. are disordered over two positions with site occupancies of 0.706 (4) and 0.294 (4). The Ba2+ ions are sandwiched between the 15-crown-5 rings and Zn2+ ions are surrounded by four N atoms from the thiocyanate ligands in a distorted tetrahedral geometry. The crystal studied was refined as an inversion twin. The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《A Newly Designed Carbohydrate-Derived Alkylamine Promotes Ullmann Type C-N Coupling Catalyzed by Copper in Water》 were Zhou, Guoquan; Chen, Wen; Zhang, Shihui; Liu, Xuemin; Yang, Zehui; Ge, Xin; Fan, Hua-Jun. And the article was published in Synlett in 2019. Electric Literature of C7H7IO The author mentioned the following in the article:

In the presence of the diglucosylethanediamine I and CuI, aryl iodides underwent green Ullman-type coupling reactions with heterocyclic amines and aniline in water mediated by Cs2CO3 to yield N-arylated nitrogen heterocycles (particularly N-aryl imidazoles and indoles) and N-phenyl-p-anisidine. The solubility of 4-iodoanisole in water in the presence and absence of I was measured; I likely functions by both chelating copper and by promoting the dissolution of 4-iodoanisole in water. In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2Electric Literature of C7H7IO) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Electric Literature of C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Ionic-Liquid-Modified Porous Au/CeMnOx Nanorods for Methyl Methacrylate (MMA) Synthesis via Direct Oxidative Esterification》 were Tian, Yun; Li, Yuchao; Zuo, Cuncun; Yin, Defeng; Wang, Ling; Zheng, Yanxia; Huang, Haofei; Fu, Zhongjun; Wang, Ming. And the article was published in ChemNanoMat in 2019. Synthetic Route of C8H8O2 The author mentioned the following in the article:

Porous MnCeOx solid solutions nanorods (PN-MnCeOx) with different pore sizes were prepared using different carbon chain lengths ionic liquids (C10mimCl, C12mimCl and C14mimCl). Series of novel catalysts with nano-Au supported on the PN-MnCeOx, were synthesized and applied to oxidative esterification of benzaldehydes to esters. Catalytic performance was evaluated in batch reactor and the relatively optimum catalyst was screened out. Kinds of characterization methods, such as XRD, TEM, XPS and BET, were applied to analyze crystal plane, microstructure, sp. surface area, and porous structure of the catalysts and the structure-activity relationship could be reasonably explained. The cyclic stability of the catalyst was also tested more than 7 times using MAL and methanol for Me methacrylate synthesis via one step oxidative esterification. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Synthetic Route of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Angiogenic potential of bone marrow derived CD133+ and CD271+ intramyocardial stem cell transplantation post MI》 was published in Cells in 2020. These research results belong to Sasse, Sarah; Skorska, Anna; Lux, Cornelia Aquilina; Steinhoff, Gustav; David, Robert; Gaebel, Ralf. Related Products of 106685-40-9 The article mentions the following:

Background: Bone marrow (BM)-derived stem cells with their various functions and characteristics have become a well-recognized source for the cell-based therapies. However, knowledge on their therapeutic potential and the shortage for a cross-link between distinct BM-derived stem cells, primed after the onset of myocardial infarction (MI), seems to be still rudimentary. Therefore, the post-examination of the therapeutic characteristics of such primed hematopoietic CD133+ and mesenchymal CD271+ stem cells was the object of the present study. Methods and Results: The effects of resp. CD133+ and CD271+ mononuclear cells alone as well as in the co-culture model have been explored with focus on their angiogenic potential. The phenotypic anal. revealed a small percentage of isolated cells expressing both surface markers. Moreover, target stem cells isolated with our standardized immunomagnetic isolation procedure did not show any neg. alterations following BM storage in regard to cell numbers and/or quality. In vitro network formation relied predominantly on CD271+ stem cells when compared with single CD133+ culture. Interestingly, CD133+ cells contributed in the tube formation, only if they were cultivated in combination with CD271+ cells. Addnl. to the in vitro examination, therapeutic effects of the primed stem cells were investigated 48 h post MI in a murine model. Hence, we have found a lower expression of transforming growth factor βeta 3 (TGF β3) as well as an increase of the proangiogenic factors after CD133+ cell treatment in contrast to CD271+ cell treatment. On the other hand, the CD271+ cell therapy led to a lower expression of the inflammatory cytokines. Conclusion: The interactions between CD271+ and CD133+ subpopulations the extent to which the combination may enhance cardiac regeneration has still not been investigated so far. We expect that the multiple characteristics and various regenerative effects of CD271+ cells alone as well as in combination with CD133+ will result in an improved therapeutic impact on ischemic heart disease. In addition to this study using 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid, there are many other studies that have used 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Related Products of 106685-40-9) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) may be used as a pharmaceutical reference standard for the quantification of the analyte in topical gel formulations using high-performance liquid chromatography technique.Related Products of 106685-40-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Carbonylative Suzuki-Miyaura cross-coupling by immobilized Ni@Pd NPs supported on carbon nanotubes》 was published in RSC Advances in 2020. These research results belong to Nan, Liu; Cai, Yalan; Li, Jixiang; Ouyang, Dujuan; Duan, Wenhui; Rouhi, Jalal; Mustapha, Mazli. Safety of 1-Iodo-2-methoxybenzene The article mentions the following:

In this study, a novel carbon nanotube (CNT) based nanocatalyst (Ni@Pd/CNT) was synthesized by modifying CNTs using Ni@Pd core-shell nanoparticles (NPs). Ni@Pd/CNT was used in catalytic carbonylative cross-coupling between aryl iodides and phenylboronic acid to afford diaryl ketones ArC(O)Ph [Ar = Ph, 2-MeC6H4, 2-NH2C6H4, etc.]. The Ni@Pd NPs possessed a magnetic nickel (Ni) core with a palladium (Pd) structural composite shell. Thus, the use of Ni had led to a reduced consumption of Pd without sacrificing the overall catalytic performance, simultaneously making it reusable as it could be conveniently recovered from the reaction mixture by using an external magnetic field. Immobilization of the Ni@Pd NPs on carbon nanotubes not only prevented their aggregation, but also significantly enhanced the accessibility of the catalytically active sites. The above mentioned approach based on carbon nanotubes and Ni@Pd NPs provided a useful platform for the fabrication of noble-metal-based nanocatalysts with easy accessibility and low cost, which may allow for an efficient green alternative for various catalytic reductions In addition to this study using 1-Iodo-2-methoxybenzene, there are many other studies that have used 1-Iodo-2-methoxybenzene(cas: 529-28-2Safety of 1-Iodo-2-methoxybenzene) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Safety of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem