Month: October 2022

In 2019,Organic Letters included an article by Huang, Jie; Ding, Jun; Ding, Tong-Mei; Zhang, Shuiyi; Wang, Yaqiu; Sha, Feng; Zhang, Shu-Yu; Wu, Xin-Yan; Li, Qiong. Electric Literature of C8H8O2. The article was titled 《Cobalt-Catalyzed Ortho-C(sp2)-H Amidation of Benzaldehydes with Dioxazolones Using Transient Directing Groups》. The information in the text is summarized as follows:

An efficient and convenient cobalt-catalyzed ortho-C(sp2)-H amidation of benzaldehydes employing dioxazolones as the aminating reagent has been developed. The key feature of this protocol is the use of green and economic earth-abundant metals cobalt as the catalyst with the p-chloroaniline as the transient directing group. Further application of our approach was demonstrated by the synthesis of C1r serine protease inhibitor 45 (I) and elastase inhibitor 49 (II). In addition to this study using 2-Methoxybenzaldehyde, there are many other studies that have used 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Electric Literature of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Fe3O4/SO3H@zeolite-Y as a novel multi-functional and magnetic nanocatalyst for clean and soft synthesis of imidazole and perimidine derivatives》 were Kalhor, Mehdi; Zarnegar, Zohre. And the article was published in RSC Advances in 2019. Recommanded Product: 135-02-4 The author mentioned the following in the article:

In this study, SO3H@zeolite-Y was synthesized by the reaction of chlorosulfonic acid with zeolite-NaY under solvent-free conditions, which was then supported by Fe3O4 nanoparticles to give SO3H@zeolite-Y (Fe3O4/SO3H@zeolite-Y) magnetic nanoparticles. Several techniques were used to evaluate the phys. and chem. characterizations of the zeolitic nanostructures. Fe3O4-loaded sulfonated zeolite was applied as a novel multi-functional zeolite catalyst for the synthesis of imidazole and perimidine derivatives This efficient methodol. has some advantages such as good to excellent yield, high purity of products, reusability of nanocatalyst, simple reaction conditions, environmental friendliness and an economical chem. procedure from the viewpoint of green chem. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Recommanded Product: 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Recommanded Product: 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Catalyst- and solvent-free ipso-hydroxylation of arylboronic acids to phenols》 were Yang, Xiufang; Jiang, Xulu; Wang, Weitao; Yang, Qi; Ma, Yangmin; Wang, Kuan. And the article was published in RSC Advances in 2019. Category: ethers-buliding-blocks The author mentioned the following in the article:

A catalyst-free method for the hydroxylation of arylboronic acids to form the corresponding phenols I [R = 2-Me, 4-MeO, 4-t-Bu, etc.] with sodium perborate as the oxidant was developed using water as the solvent. Under the reaction conditions, the yield of phenol reached 92% at only 5 min. Moreover, the reaction could be conducted without a catalyst under the solvent-free condition, the efficiency of which was as high as that of a liquid-phase reaction. Using a microcalorimeter, the reaction was found to be an exothermic reaction. The reaction mechanism was investigated and understood via DFT calculations, which revealed that it was a nucleophilic reaction. In the part of experimental materials, we found many familiar compounds, such as m-Methoxyphenol(cas: 150-19-6Category: ethers-buliding-blocks)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Small organic molecules with tailored structures: initiators in the transition-metal-free C-H arylation of unactivated arenes》 was published in RSC Advances in 2020. These research results belong to Liu, Zhenghui; Wang, Peng; Chen, Yu; Yan, Zhenzhong; Chen, Suqing; Chen, Wenjun; Mu, Tiancheng. Related Products of 529-28-2 The article mentions the following:

In this article, an optimized catalytically active mol., (2-(methylamino)phenyl)methanol, was designed. A broad range of aryl iodides RI (R = 2-fluorophenyl, thiophen-3-yl, pyridin-4-yl, etc.) could be converted into the corresponding arylated products RR1 (R1 = Ph, 4-methylphenyl) at 100°C over 24 h with good to excellent yields. Mechanistic experiments verified that radicals participated in this catalytic transformation and that the cleavage of the aromatic C-H bond was not the rate determining step. A K+ capture experiment by 18-crown-6 emphasized the significance of the cation species of the strong base. Fourier transform IR spectroscopy proved that the catalytic system was activated by the hydrogen bonds between small organic mols. and tBuOK. Also, a clear mechanism was proposed. This transition-metal-free method affords a promising system for efficient and inexpensive synthesis of biaryls via a user-friendly approach, as confirmed by scale-up experiments In the experiment, the researchers used many compounds, for example, 1-Iodo-2-methoxybenzene(cas: 529-28-2Related Products of 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Related Products of 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Continuous-Flow Synthesis of Tramadol from Cyclohexanone》 was published in Synlett in 2020. These research results belong to Monos, Timothy M.; Jaworski, Jonathan N.; Stephens, John C.; Jamison, Timothy F.. Quality Control of 1-Bromo-3-methoxybenzene The article mentions the following:

A multioperation, continuous-flow platform for the synthesis of tramadol, ranging from gram to decagram quantities, is described. The platform is segmented into two halves allowing for a single operator to modulate between preparation of the intermediate by Mannich addition or complete the fully concatenated synthesis. All purification operations are incorporated in-line for the Mannich reaction. ‘Flash’ reactivity between meta-methoxyphenyl magnesium bromide and the Mannich product was controlled with a static helical mixer and tested with a combination of flow and batch-based and factorial evaluations. These efforts culminated in a rapid production rate of tramadol (13.7 g°h -1) sustained over 56 reactor volumes A comparison of process metrics including E-Factor, production rate, and space-time yield are used to contextualize the developed platform with respect to established engineering and synthetic methods for making tramadol. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0Quality Control of 1-Bromo-3-methoxybenzene)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Quality Control of 1-Bromo-3-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Single crystal X-ray structure for the disordered two independent molecules of novel isoflavone: synthesis, hirshfeld surface analysis, inhibition and docking studies on IKKβ of 3-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-6,7-dimethoxy-4H-chromen-4-one》 was published in Crystals in 2020. These research results belong to Shin, Soon Young; Lee, Young Han; Lim, Yoongho; Lee, Ha Jin; Lee, Ji Hye; Yoo, Miri; Ahn, Seunghyun; Koh, Dongsoo. Formula: C5H13NO2 The article mentions the following:

The structure of the isoflavone compound, I was elucidated by 2D-NMR spectra, mass spectrum and single crystal X-ray crystallog. Compound I was crystallized in the monoclinic space group P21/c with the cell parameters; a = 12.0654(5) Å, b = 11.0666(5) Å, c = 23.9550(11) Å, β = 101.3757(16)°, V = 3135.7(2) Å3, and Z = 8. The asym. unit of compound I consists of two independent mols. 5I and 5II. Both mols. exhibit the disorder of each methylene group present in their 1,4-dioxane rings with relative occupancies of 0.599(10) (5I) and 0.812(9) (5II) for the major component A, and 0.401(10) (5I) and 0.188(9) (5II) for the minor component B, resp. Each independent mol. revealed remarkable discrepancies in bond lengths, bond angles and dihedral angles in the disordered regions of 1,4-dioxane rings. The common feature of the mols. 5I and 5II were a chromone ring and a benzodioxin ring, which are more tilted towards each other in 5I than in 5II. An addnl. difference between the mols. was seen in the relative disposition of two methoxy substituents. In the crystal, the mol. 5II forms inversion dimers which were linked into chains along an a-axis direction by intermol. C-H···O interactions. Addnl. C-H···O hydrogen bonds connected the mols. 5I and 5II each other to form a three-dimensional network. Hirshfeld surface anal. evaluated the relative intermol. interactions which contribute to each crystal structure 5I and 5II. Western blot anal. demonstrated that compound 5 inhibited the TNFα-induced phosphorylation of IKKα/β, resulting in attenuating further downstream NF-κB signaling. A mol. docking study predicted the possible binding of compound I to the active site of IKKβ. Compound I showed an inhibitory effect on the clonogenicity of HCT116 human colon cancer cells. These results suggest that compound I was used as a platform for the development of an anti-cancer agent targeting IKKα/β. In the experimental materials used by the author, we found N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《A hemicyanine-based “”turn-on”” fluorescent probe for the selective detection of Cu2+ ions and imaging in living cells》 was written by Li, Bai; Kou, Jiejian; Mei, Huihui; Gu, Xin; Wang, Minghui; Xie, Xinmei; Xu, Kuoxi. Recommanded Product: 673-22-3 And the article was included in Analytical Methods in 2020. The article conveys some information:

A novel hemicyanine-based fluorescent probe was developed for the fast, selective, and reversible detection of Cu2+ ions with “”turn-on”” fluorescence response in the aqueous solution The sensing mode was demonstrated through fluorescence, UV-vis, HRMS, 1H NMR, and DFT calculations The probe was successfully used for the imaging of Cu2+ ions in living cells. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Highly Regioselective Synthesis of Multisubstituted Pyrroles via Ag-Catalyzed [4+1C]insert Cascade》 was written by Luo, Kaixiu; Mao, Shuai; He, Kun; Yu, Xianglin; Pan, Junhong; Lin, Jun; Shao, Zhihui; Jin, Yi. SDS of cas: 4637-24-5 And the article was included in ACS Catalysis in 2020. The article conveys some information:

An efficient [4+1C]insert approach to the coupling of enaminones with donor/acceptor or donor/donor carbenes by AgOTf catalyzed C-C bond carbenoid formal insertion/cyclization/[1,5]-shift cascade reaction was successfully developed, providing distinct chemo- and regio-selective multisubstituted pyrroles I [R = Me, Ph, 2-thienyl, etc.; R1 = Ph, 2-furanyl, 2-naphthyl, etc.; R2 = Et, cyclopropyl, Ph, etc.; R3 = CO2Me, CO2Et, Ph, etc.]. The plausible reaction mechanism involved two catalytic cycles, in the first one, silver ions regioselectively catalyze the C-C bond insertion reaction and in second one, silver ions chemo- and regio-selectively control the cyclization and [1,5]-shift reactions. This method not only provided convenience and applies atom economy in the synthesis multisubstituted pyrroles but also presents an entry point for further pyrrole diversification via facile modification of resulting 4-H-pyrrole products, as displayed by a short formal synthesis of the natural product lamellarin L. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5SDS of cas: 4637-24-5) was used in this study.

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 4637-24-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wu, Yongdi; Liu, Na; Qi, Meifang; Qiao, Huihao; Lu, Xuelian; Ma, Li; Zhou, Yirong; Zhang, Fang-Lin published their research in Organic Letters in 2021. The article was titled 《Monodentate Transient Directing Group Assisted Ruthenium(II)-Catalyzed Direct ortho-C-H Imidation of Benzaldehydes for Diverse Synthesis of Quinazoline and Fused Isoindolinone》.Related Products of 135-02-4 The article contains the following contents:

2-Fluoro-5-(trifluoromethyl)aniline was found to be a suitable monodentate transient directing group (MonoTDG) to enable Ru(II)-catalyzed intermol. direct ortho-C(sp2)-H imidation of benzaldehydes. N-Tosyloxyphthalimide was used as an alternative azide-free amidation reagent to achieve high efficiency and good functional group tolerance. Moreover, the reaction could be enlarged to gram scale, and the amidated product could be readily converted into useful quinazoline and fused isoindolinone scaffolds by one-step derivatization. In the part of experimental materials, we found many familiar compounds, such as 2-Methoxybenzaldehyde(cas: 135-02-4Related Products of 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is used as a flavor agent in foods including nonalcoholic/alcoholic beverages, baked goods, chewing gum, confections, frozen dairy, fruit ices, hard/soft candy, instant coffee, tea, Jams, jellies, and milk products. It also has been used to obtain good enantioselectivities using Cu(OAc)(2)-bis(oxazolines) via hydrogen bonding in asymmetric Henry reaction.Related Products of 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Marijan, Sandra; Mastelic, Angela; Markotic, Anita; Rezic-Muzinic, Nikolina; Vucenovic, Nikolina; Barker, David; Pilkington, Lisa I.; Reynisson, Johannes; Culic, Vedrana Cikes published their research in Medicines in 2021. The article was titled 《Thieno[2,3-b]Pyridine Derivative Targets Epithelial, Mesenchymal and Hybrid CD15s+ Breast Cancer Cells》.COA of Formula: C5H13NO2 The article contains the following contents:

The adhesion of cancer cells to vascular endothelium is a critical process in hematogenous metastasis and might be similar to the recruitment of leukocytes at the site of inflammation. It is mediated by E-selectin and its ligands, of which the most stereospecific is a glycoconjugate sialyl Lewis x (CD15s), which may be expressed as an oligosaccharide branch of the CD44 glycoprotein, as well as a self-contained glycosphingolipid. It is also known that increased sialylation of glycoconjugates is a feature of malignant cells. The aim of the study was to analyze the effect of a novel thieno[2,3-b]pyridine, compound 1, in MDA-MB-231 triple-neg. breast cancer cells (TNBCs) upon CD15s and CD44 expression in different cell subpopulations using flow cytometry. CD15s expression was compared between mesenchymal-like cancer stem cells (CSC, CD44+CD24-), epithelial cells without CD44 (CD44-CD24+ and CD44-CD24-), and CD44+CD24+ cells that exhibit mesenchymal and epithelial features. In addition, expression of CD44 in CD15s+CSC and CD15s-CSC was determined Compound 1 significantly decreased the percentage of CD15s+CSC, CD15s+CD44+CD24+, and CD15s+CD44- subpopulations, as well as the expression of CD15s in CD44+CD24+ and CD44- cells, and therefore shows potential as a treatment for TNBC. The experimental part of the paper was very detailed, including the reaction process of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5COA of Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.COA of Formula: C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem