《Highly Regioselective Synthesis of Multisubstituted Pyrroles via Ag-Catalyzed [4+1C]insert Cascade》 was written by Luo, Kaixiu; Mao, Shuai; He, Kun; Yu, Xianglin; Pan, Junhong; Lin, Jun; Shao, Zhihui; Jin, Yi. SDS of cas: 4637-24-5 And the article was included in ACS Catalysis in 2020. The article conveys some information:
An efficient [4+1C]insert approach to the coupling of enaminones with donor/acceptor or donor/donor carbenes by AgOTf catalyzed C-C bond carbenoid formal insertion/cyclization/[1,5]-shift cascade reaction was successfully developed, providing distinct chemo- and regio-selective multisubstituted pyrroles I [R = Me, Ph, 2-thienyl, etc.; R1 = Ph, 2-furanyl, 2-naphthyl, etc.; R2 = Et, cyclopropyl, Ph, etc.; R3 = CO2Me, CO2Et, Ph, etc.]. The plausible reaction mechanism involved two catalytic cycles, in the first one, silver ions regioselectively catalyze the C-C bond insertion reaction and in second one, silver ions chemo- and regio-selectively control the cyclization and [1,5]-shift reactions. This method not only provided convenience and applies atom economy in the synthesis multisubstituted pyrroles but also presents an entry point for further pyrrole diversification via facile modification of resulting 4-H-pyrrole products, as displayed by a short formal synthesis of the natural product lamellarin L. In addition to this study using N,N-Dimethylformamide Dimethyl Acetal, there are many other studies that have used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5SDS of cas: 4637-24-5) was used in this study.
N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.SDS of cas: 4637-24-5
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem