《Continuous-Flow Synthesis of Tramadol from Cyclohexanone》 was published in Synlett in 2020. These research results belong to Monos, Timothy M.; Jaworski, Jonathan N.; Stephens, John C.; Jamison, Timothy F.. Quality Control of 1-Bromo-3-methoxybenzene The article mentions the following:
A multioperation, continuous-flow platform for the synthesis of tramadol, ranging from gram to decagram quantities, is described. The platform is segmented into two halves allowing for a single operator to modulate between preparation of the intermediate by Mannich addition or complete the fully concatenated synthesis. All purification operations are incorporated in-line for the Mannich reaction. ‘Flash’ reactivity between meta-methoxyphenyl magnesium bromide and the Mannich product was controlled with a static helical mixer and tested with a combination of flow and batch-based and factorial evaluations. These efforts culminated in a rapid production rate of tramadol (13.7 g°h -1) sustained over 56 reactor volumes A comparison of process metrics including E-Factor, production rate, and space-time yield are used to contextualize the developed platform with respect to established engineering and synthetic methods for making tramadol. In the experimental materials used by the author, we found 1-Bromo-3-methoxybenzene(cas: 2398-37-0Quality Control of 1-Bromo-3-methoxybenzene)
1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Quality Control of 1-Bromo-3-methoxybenzene
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