Month: November 2022

Efficient and Mild Reductive Amination of Carbonyl Compounds Catalyzed by Dual-Function Palladium Nanoparticles was written by Jv, Xinchun;Sun, Shuting;Zhang, Qun;Du, Muyao;Wang, Lan;Wang, Bo. And the article was included in ACS Sustainable Chemistry & Engineering in 2020.Computed Properties of C10H15NO The following contents are mentioned in the article:

Primary amines are valuable building blocks for a large number of chems., developing efficient synthetic routes toward primary amines and particularly those proceeding under mild conditions are highly desirable and rather challenging. Presented here is a highly efficient procedure enabling itself to proceed in H₂O using H₂ of 1 atm (0.1 MPa) for the reductive amination of carbonyl compounds Several palladium-based nanoparticle (Pd-NP) catalysts were prepared, and one emerged to be the most suitable and classified as nanoparticles, due to its high catalytic activity, reactions were allowed to proceed at room temperature using NH₃, and the corresponding primary amines can be afforded with yields of up to 99%. Some control reactions were carried out, revealing that H₂ is pivotal for activating the Pd-NPs. The fact that the Pd-NPs can catalyze both reductive amination of carbonyl compounds and hydrogenation of imines proves Pd-NPs to be a dual-function catalyst, and a plausible mechanism was proposed. A dual-function catalyst promoted the reductive amination of carbonyl compounds with high efficiency using NH₃·H₂O and H₂ (1 atm) under mild conditions and generated H₂O as the sole byproduct. This study involved multiple reactions and reactants, such as N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3Computed Properties of C10H15NO).

N-(3-Methoxybenzyl)ethanamine (cas: 140715-61-3) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Computed Properties of C10H15NO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hydrothermal Depolymerization of Kraft Lignins with Green C₁-C₃ Alcohol-Water Mixtures was written by Guo, Ming;Maltari, Riku;Zhang, Rui;Kontro, Jussi;Ma, Enlu;Repo, Timo. And the article was included in Energy & Fuels in 2021.Name: 4-Hydroxy-3-methoxyphenethanol The following contents are mentioned in the article:

Lignin is a potential renewable raw material for synthesis of aromatic mols. and materials. Particularly, Kraft-type lignins are abundantly available as a byproduct of wood and paper industries. Currently, there are practically no valuable products made using this highly complex polymer. Within this work, we have investigated the straightforward, high-yield depolymerization of two different tech. lignins (Indulin AT and alk. lignin) using only a mixture of green short-chain (C₁-C₃) alcs. and water as solvents. As shown here, at a temperature of 220°C, autogenous pressure, and isopropanol/water as a co-solvent medium, it is possible to cleave Kraft lignin without char-forming side reactions. The obtained so-called “light” oil contains guaiacol-based monomeric units of 23 wt % yield together with liquid oligomers of 13 wt % yield combining liquid-liquid and solid-liquid extraction Two-dimensional NMR anal. of lignin residues showed that the isopropanol/water treatment caused a marked breakdown of the intermol. β-O-4 and β-β bonds; thus, the depolymerization produced monomers and lignin residues with lower mol. weight The results suggested a synergistic effect between isopropanol and water. No sign of repolymn. reactions could be observed with this process. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Name: 4-Hydroxy-3-methoxyphenethanol).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: 4-Hydroxy-3-methoxyphenethanol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hexadentate technetium-99m bis(thiosemicarbazonato) complexes: synthesis, characterization and biodistribution was written by Kelderman, Cormac A. A.;Davey, Patrick R. W. J.;Ma, Michelle T.;de Veer, Michael;Salimova, Ekaterina;Donnelly, Paul S.;Paterson, Brett M.. And the article was included in Dalton Transactions in 2022.Safety of 2-Methoxyethylamine The following contents are mentioned in the article:

The syntheses of non-oxido/non-nitrido bis(thiosemicarbazonato)technetium(V) complexes featuring a series of alkyl and ether substituents is presented. The bis(thiosemicarbazones) were radiolabeled with technetium-99m using an optimized one-pot synthesis from [^99mTc][TcO₄]^–. Mass spectrometry and computational chem. data suggested a distorted trigonal prismatic coordination environment for the bis(thiosemicarbazonato)technetium(V) complexes by way of a bis(thiosemicarbazone)technetium(V)-oxido intermediate complex. The lipophilicities of the complexes were estimated using distribution ratios and three of the new complexes were investigated in mice using kinetic planar imaging and ex vivo biodistribution experiments and were compared to [^99mTc][TcO₄]^–. Modification of the technetium complexes with various lipophilic functional groups altered the biodistributions of the complexes in mice despite evidence suggesting limited stability of the complexes to biol. relevant conditions. The most hydrophilic complex had higher uptake in the kidneys compared to the most lipophilic, which had higher liver uptake, suggesting modification of the excretion pathways. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Safety of 2-Methoxyethylamine).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of 2-Methoxyethylamine

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Bisdemethoxycurcumin suppresses human brain glioblastoma multiforme GBM 8401 cell migration and invasion via affecting NF-κB and MMP -2 and MMP -9 signaling pathway in vitro was written by Chen, Chiung-Ju;Shang, Hung-Sheng;Huang, Yuan-Li;Tien, Ni;Chen, Yung-Liang;Hsu, Sheng-Yao;Wu, Rick Sai-Chuen;Tang, Chien-Lun;Lien, Jin-Cherng;Lee, Mei-Hui;Lu, Hsu-Feng;Hsia, Te-Chun. And the article was included in Environmental Toxicology in 2022.Name: Bisdemethoxycurcumin The following contents are mentioned in the article:

Human glioblastoma (GBM) is one of the common cancer death in adults worldwide, and its metastasis will lead to difficult treatment. Finding compounds for future to develop treatment is urgent. Bisdemethoxycurcumin (BDMC), a natural product, was isolated from the rhizome of turmeric (Curcuma longa), which has been shown to against many human cancer cells. In the present study, we evaluated the antimetastasis activity of BDMC in human GBM cells. Cell proliferation, cell viability, cellular uptake, wound healing, migration and invasion, and western blotting were analyzed. Results indicated that BDMC at 1.5-3μM significantly decreased the cell proliferation by MTT assay. BDMC showed the highest uptake by cells at 3 h. After treatment of BDMC at 12-48 h significantly inhibited cell motility in GBM 8401 cells by wound healing assay. BDMC suppressed cell migration and invasion at 24 and 48 h treatment by transwell chamber assay. BDMC significantly decreased the levels of proteins associated with PI3K/Akt, Ras/MEK/ERK pathways and resulted in the decrease in the expressions of NF-κB, MMP-2, MMP-9, and N-cadherin, leading to the inhibition of cell migration and invasion. These findings suggest that BDMC may be a potential candidate for the antimetastasis of human GBM cells in the future. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Name: Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Name: Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, synthesis, and biological evaluation of 4-(1H-1,2,3-triazol-1-yl)benzamides as HSP90 inhibitors was written by He, Tingting;Zhu, Shulei;Lu, Wei. And the article was included in Molecular Diversity.Application of 109-85-3 The following contents are mentioned in the article:

Heat shock protein 90 (HSP90) is a promising anticancer drug target, which could be employed to construct HSP90 inhibitors-based drug conjugates for selective tumor therapy. Herein, a series of 4-(1H-1,2,3-triazol-1-yl)benzamides I [R = Me, n-Bu, n-Hexyl, etc.] were rationally designed, synthesized as HSP90 inhibitors, and their structures were characterized by ¹H NMR, ¹³C NMR, and HR-MS. Preliminary HSP90 binding assay showed that compounds I [R = Bu, tetrahydrofuran-3-yl, tetrahydro-2H-pyran-4-yl, 1,1-dioxo-tetrahydrothiopyran-4-yl, 2-cis-hydroxycyclopentyl, 4-transhydroxycyclohexyl] exhibited significant HSP90α binding affinity. Among these selected compound I [R = 4-transhydroxycyclohexyl] displayed the most potent anti-proliferative activities and particularly in Capan-1 cell line. Mol. modeling studies also confirmed possible mode of interaction between 6u and the binding sites of HSP90 by hydrogen bond and hydrophobic interactions. Above all, these encouraging data indicated that compound I [R = 4-transhydroxycyclohexyl] could be used as a HSP90 inhibitor for further study and helped the recognition of the 4-(1H-1,2,3-triazol-1-yl)benzamide motif as a new scaffold for HSP90 inhibitors. This study involved multiple reactions and reactants, such as 2-Methoxyethylamine (cas: 109-85-3Application of 109-85-3).

2-Methoxyethylamine (cas: 109-85-3) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 109-85-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Curcuma zedoaria extract as a novel corrosion inhibitor for mild steel in 0.5 M H₂SO₄ was written by Soltani, Nasrin;Tavakkoli, Nahid;Khayatkashani, Maryam;Eslami, Elham. And the article was included in Iranian Journal of Analytical Chemistry in 2022.Reference of 33171-05-0 The following contents are mentioned in the article:

In this study, curcuma zedoaria extract was investigated as a mild steel (MS) corrosion inhibitor in 0.5 M H₂SO₄ solution by conventional methods of weight loss (WL), electrochem. impedance spectroscopy (EIS) and polarization at 25°C. The highest percentage of inhibition was obtained for the concentration of 0.5 g/l of curcuma zedoaria extract The results of polarization method showed that curcuma zedoaria extract acts as a mixed inhibitor. Examination of MS immersion time by weight loss method showed that with increasing immersion time, the inhibitory effect decreases in low concentrations of curcuma zedoaria extract but in higher concentrations of curcuma zedoaria extract (concentration 1.0 g/L), the inhibitory effect remains almost constant over time. The effect of temperature on the performance of curcuma zedoaria extract by electrochem. polarization method in the temperature range of 35-65°C shows a decrease in inhibition percentage with increasing temperature Adsorption of curcuma zedoaria extract mols. on the surface of MS at all studied temperatures follows the Langmuir adsorption isotherm. Using the results of kinetic and thermodn. calculations, the adsorption of mols. of curcuma zedoaria extract on the surface of MS phys. adsorption type was observed This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Reference of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Reference of 33171-05-0

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effect of fermentation temperature on volatile compounds of Petit Verdot red wines from the Spanish region of La Mancha (central-southeastern Spain) was written by Izquierdo-Canas, P. M.;Gonzalez Vinas, M. A.;Mena-Morales, A.;Perez Navarro, J.;Garcia-Romero, E.;Marchante-Cuevas, L.;Gomez-Alonso, S.;Sanchez-Palomo, E.. And the article was included in European Food Research and Technology in 2020.Recommanded Product: 2380-78-1 The following contents are mentioned in the article:

The aim of this work was to research the relationship between volatile composition of Petit Verdot red wines and the fermentation temperature Winemaking process was carried out at 17°C, 21°C, and 25°C temperatures Solid-phase extraction (SPE) and gas chromatog.-mass spectrometry (GC-MS) were used to analyze volatile compounds The odor activity values (OAVs) from the different compounds were classified into seven odorant series that describe the aroma profile (fruity, floral, green/fresh, sweet, spicy, fatty, and other odours). The value of each aromatic series was obtained by adding the OAVs of the volatile compounds to each series. The volatile composition was significantly affected by the temperature of the fermentation In general, the increase in the fermentation temperature of La Mancha Petit Verdot red wines from 17 to 25°C produced an increase in the concentration of volatile aroma compounds The highest aroma contributions to Petit Verdot wine were fruity, sweet and floral series, followed by fatty and spicy series, regardless of fermentation temperature The highest values of aromatic series were found in wines fermented at 21°C. The results of this work show that changes in the fermentation temperature of wines can have a significant impact on their volatile compound profile. This study involved multiple reactions and reactants, such as 4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1Recommanded Product: 2380-78-1).

4-Hydroxy-3-methoxyphenethanol (cas: 2380-78-1) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Recommanded Product: 2380-78-1

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dithiols as Liquid Crystalline Building Blocks for Smart Polymers via Thiol-yne Click Chemistry was written by Lupi, Flavia;Martella, Daniele;Nocentini, Sara;Antonioli, Diego;Laus, Michele;Wiersma, Diederik S.;Parmeggiani, Camilla. And the article was included in ACS Applied Polymer Materials in 2021.Product Details of 103-16-2 The following contents are mentioned in the article:

Since 30 years, liquid crystalline elastomers (LCEs) have been attracting the attention of many researchers thanks to their anisotropic mol. structure which allows them to build up artificial muscles. Possible applications span from soft robotics to biomedical or tunable optical devices. The power of thiol-yne click chem. was recently demonstrated in the preparation of smart polymers, in particular LCEs, in which the mesogenic units are incorporated both in the main-chain and as pendant groups. To enrich the library of available LCE materials, in this work, several liquid crystalline dithiols and alkynes have been synthesized and copolymerized to obtain elastomers with different thermomech. properties. The architecture of the main chain was found to play a prominent role in modulating the clearing point in a range of 60°C, whereas only a minor contribution is given by the mesogens in the side chain. On the other hand, the mech. response resulted highly sensitive to fine details of the side-chain structure. Accordingly, the present study not only improves the basic understanding of the chem.-phys. properties of LCEs but paves the way to the preparation of multicomponent actuators able to deform in different temperature ranges, thus ultimately leading to complex soft robotic operations. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Product Details of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Product Details of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dithiols as Liquid Crystalline Building Blocks for Smart Polymers via Thiol-yne Click Chemistry was written by Lupi, Flavia;Martella, Daniele;Nocentini, Sara;Antonioli, Diego;Laus, Michele;Wiersma, Diederik S.;Parmeggiani, Camilla. And the article was included in ACS Applied Polymer Materials in 2021.Computed Properties of C13H12O2 The following contents are mentioned in the article:

Since 30 years, liquid crystalline elastomers (LCEs) have been attracting the attention of many researchers thanks to their anisotropic mol. structure which allows them to build up artificial muscles. Possible applications span from soft robotics to biomedical or tunable optical devices. The power of thiol-yne click chem. was recently demonstrated in the preparation of smart polymers, in particular LCEs, in which the mesogenic units are incorporated both in the main-chain and as pendant groups. To enrich the library of available LCE materials, in this work, several liquid crystalline dithiols and alkynes have been synthesized and copolymerized to obtain elastomers with different thermomech. properties. The architecture of the main chain was found to play a prominent role in modulating the clearing point in a range of 60°C, whereas only a minor contribution is given by the mesogens in the side chain. On the other hand, the mech. response resulted highly sensitive to fine details of the side-chain structure. Accordingly, the present study not only improves the basic understanding of the chem.-phys. properties of LCEs but paves the way to the preparation of multicomponent actuators able to deform in different temperature ranges, thus ultimately leading to complex soft robotic operations. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Computed Properties of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Computed Properties of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and characterization of new bent-core liquid crystal with a ferroelectric-like switching / modified magnetite nanocomposite was written by Ozkonstanyan, Aykun;Mert, Hatice Hande;Mert, Mehmet Selcuk;Bilgin Eran, Belkiz;Ocak, Hale. And the article was included in Journal of Molecular Structure in 2020.Product Details of 103-16-2 The following contents are mentioned in the article:

A new bent-core liquid crystal (LC) compound 4-Cyano-1,3-phenylenebis[4-(4-(S)-2-Dodecyloxypropionyloxyphenoxycarbonyl)benzoate] (CyPDB) consisting of O-dodecyl lactate substituted terephthalate based rod-like units which were located at 1,3-positions of 4-cyanoresorcinol central unit has been synthesized and LC/1.0% modified Fe₃O₄ nanocomposite has been prepared The effects of being the doped with 1.0% modified Fe₃O₄ (magnetite) nanoparticles on mesomorphic properties of the new bent-core liquid crystal, which exhibits an enantiotropic SmA phase with a ferroelec.-like switching, were investigated by differential scanning calorimetry, optical polarizing microscopy and electro-optic studies. The surface of Fe₃O₄ (magnetite) nanoparticles was modified with a silane surfactant, octadecyltrimethoxysilane (OTMS), used as a compatibilizer for the attractive interaction of liquid crystal mol. with Fe₃O₄ nanoparticles. The size, morphol. and distribution of modified Fe₃O₄ (magnetite) nanoparticles in LC host were investigated by using Transmission Electron Microscope (TEM) and SEM (SEM). The magnetic properties of nanocomposite were studied using a vibrating-Sample Magnetometer (VSM). This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Product Details of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Product Details of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem