Month: November 2022

On January 31, 2022, Fang, Jing; Li, Ting; Ma, Xiang; Sun, Jiuchang; Cai, Lei; Chen, Qi; Liao, Zhiwen; Meng, Lingkui; Zeng, Jing; Wan, Qian published an article.COA of Formula: C13H11BrS The title of the article was Discriminating non-ylidic carbon-sulfur bond cleavages of sulfonium ylides for alkylation and arylation reactions. And the article contained the following:

A sulfonium ylide participated alkylation and arylation under transition-metal free conditions was described. The disparate reaction pattern allowed the sep. activation of non-ylidic S-alkyl and S-aryl bond. Under acidic conditions, sulfonium ylides served as alkyl cation precursors which facilitated the alkylations. While under alk. conditions, cleavage of non-ylidic S-aryl bond produces O-arylated compounds efficiently. The robustness of the protocols were established by the excellent compatibility of wide variety of substrates including carbohydrates. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).COA of Formula: C13H11BrS

The Article related to sulfonium ylide preparation alkylation arylation, General Organic Chemistry: Synthetic Methods and other aspects.COA of Formula: C13H11BrS

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 26, 2022, Yang, Tao; Li, Xiaoqian; Deng, Shuang; Qi, Xiaotian; Cong, Hengjiang; Cheng, Hong-Gang; Shi, Liangwei; Zhou, Qianghui; Zhuang, Lin published an article.Electric Literature of 578-58-5 The title of the article was From N-H Nitration to Controllable Aromatic Mononitration and Dinitration-The Discovery of a Versatile and Powerful N-Nitropyrazole Nitrating Reagent. And the article contained the following:

Herein,the identification of a powerful nitrating reagent, 5-methyl-1,3-dinitro-1H-pyrazole, from the N-nitro-type reagent library constructed using a practical N-H nitration method was reported. This nitrating reagent behaved as a controllable source of the nitronium ion, enabling mild and scalable nitration of a broad range of (hetero)arenes with good functional group tolerance. Of note, this nitration method was controlled by manipulating the reaction conditions to furnish mononitrated or dinitrated product selectively. The value of this method in medicinal chem. was well established by its efficient late-stage C-H nitration of complex biorelevant mols. D. functional theory (DFT) calculations and preliminary mechanistic studies reveal that the powerfulness and versatility of this nitrating reagent were due to the synergistic “nitro effect” and “methyl effect”. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Electric Literature of 578-58-5

The Article related to arene nitropyrazole nitration, nitroarene preparation, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On May 4, 2001, Bravo, Anna; Dordi, Barbara; Fontana, Francesca; Minisci, Francesco published an article.Application of 53136-21-3 The title of the article was Oxidation of Organic Sulfides by Br2 and H2O2. Electrophilic and Free-Radical Processes. And the article contained the following:

The bromine-catalyzed oxidation of sulfides with hydrogen peroxide was studied. Diaryl sulfides do not react with hydrogen peroxide and a catalytic amount of bromine; the latter is consumed by electrophilic aromatic substitution and no further reaction occurs. Dibenzyl sulfide reacts with hydrogen peroxide and a catalytic amount of bromide leading mainly to dibenzyl sulfoxide and minor amounts of benzyl bromide, benzenemethanesulfonic acid, benzyl alc. and benzaldehyde. Benzyl bromide and benzenemethanesulfonic acid were obtained in almost quant. yield by using stoichiometric amounts of bromine in the absence of hydrogen peroxide. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Application of 53136-21-3

The Article related to sulfide oxidation bromine peroxide, sulfoxide preparation, General Organic Chemistry: Synthetic Methods and other aspects.Application of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 29, 2020, Song, Song; Li, Xinyao; Wei, Jialiang; Wang, Weijin; Zhang, Yiqun; Ai, Lingsheng; Zhu, Yuchao; Shi, Xiaomeng; Zhang, Xiaohui; Jiao, Ning published an article.Safety of 2-Methoxynaphthalene The title of the article was DMSO-catalysed late-stage chlorination of (hetero)arenes. And the article contained the following:

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Safety of 2-Methoxynaphthalene

The Article related to arene heteroarene chlorination dimethyl sulfoxide catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Safety of 2-Methoxynaphthalene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 29, 2020, Song, Song; Li, Xinyao; Wei, Jialiang; Wang, Weijin; Zhang, Yiqun; Ai, Lingsheng; Zhu, Yuchao; Shi, Xiaomeng; Zhang, Xiaohui; Jiao, Ning published an article.Application of 578-58-5 The title of the article was DMSO-catalysed late-stage chlorination of (hetero)arenes. And the article contained the following:

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Application of 578-58-5

The Article related to arene heteroarene chlorination dimethyl sulfoxide catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Application of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 29, 2020, Song, Song; Li, Xinyao; Wei, Jialiang; Wang, Weijin; Zhang, Yiqun; Ai, Lingsheng; Zhu, Yuchao; Shi, Xiaomeng; Zhang, Xiaohui; Jiao, Ning published an article.Quality Control of 1,4-Dimethoxybenzene The title of the article was DMSO-catalysed late-stage chlorination of (hetero)arenes. And the article contained the following:

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Quality Control of 1,4-Dimethoxybenzene

The Article related to arene heteroarene chlorination dimethyl sulfoxide catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 1,4-Dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 29, 2020, Song, Song; Li, Xinyao; Wei, Jialiang; Wang, Weijin; Zhang, Yiqun; Ai, Lingsheng; Zhu, Yuchao; Shi, Xiaomeng; Zhang, Xiaohui; Jiao, Ning published an article.Synthetic Route of 91-16-7 The title of the article was DMSO-catalysed late-stage chlorination of (hetero)arenes. And the article contained the following:

A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).Synthetic Route of 91-16-7

The Article related to arene heteroarene chlorination dimethyl sulfoxide catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 91-16-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On February 28, 2021, Pynar, Suleyman Mesut; Erez, Mehmet Emre; Fidan, Mehmet; Erodlu, Huseyin; Dalar, Abdullah published an article.COA of Formula: C8H10O2 The title of the article was Determination of Biological Activity and Active Substances of Thecocarpus Carvifolius (BOISS.) Hedge & Lamond. And the article contained the following:

We have studied the antioxidant activity and analyzed active substances of the aqueous and methanol extracts of endemic species Thecocarpus carvifolius Hedge and Lamond. The antioxidant activity was identified and assessed using the DPPH, FRAP and iron chelating capacity assay. Active substances were detection, total phenolic, flavonoids and volatile compounds were analyzed. According to DPPH analyzes, the inhibition percentage was 48.57% for aqueous extract and 76.34% for methanol extract The FRAP reduction capacity was determined as 3.32 mg/mL for aqueous extract and 11.75 mg/mL FESO4 for methanol extract The total concentrations of phenolics and flavonoids were calculated as 64.08 – 35.29μg/mL and 146.84 – 555.66μg/mL in aqueous and methanol extracts, resp. Finally, five volatile compounds were detected in methanol extracts The results indicated that the endemic species of T. carvifolius can be evaluated as a natural antioxidant plant. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).COA of Formula: C8H10O2

The Article related to thecocarpus myrecene limonene terpinolene veratrole antioxidant, Plant Biochemistry: Composition and Products and other aspects.COA of Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On September 17, 2020, Ban, Shintaro; Endo, Tomotake; Matsui, Rikako; Morita, Nobuyoshi; Hashimoto, Yoshimitsu; Tanaka, Kosaku III; Tamura, Osamu published an article.Synthetic Route of 157869-15-3 The title of the article was Intramolecular activation of imidate with cationic gold(I) catalyst: A new benzylation reaction of alcohols. And the article contained the following:

Benzylation of alcs. with benzyl (Z)-2,2,2-trifluoro-N-(2-alkynylphenyl)acetimidates I (R1 = nBu, C6H5, 4-CF3C6H4, 4-MeOC6H4; R2 = H, NO2, OMe) in the presence of a cationic gold(I) catalyst was investigated. Reagent I (R1 = C6H5; R2 = OMe) was the most effective, affording benzyl ethers in good yields. This results indicate that these gold(I)-activated imidates are effective leaving groups. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Synthetic Route of 157869-15-3

The Article related to benzyl ether preparation gold catalyst, alc imidate benzylation, General Organic Chemistry: Synthetic Methods and other aspects.Synthetic Route of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On December 31, 2009, Azizi, N.; Amiri, A. Khajeh; Bolourtchian, M.; Saidi, M. R. published an article.Product Details of 53136-21-3 The title of the article was A green and highly efficient alkylation of thiols in water. And the article contained the following:

An environmentally benign and efficient process for the preparation of thioethers was developed by simple and practical reactions of alkyl halides and thiols in H2O in the presence of K2CO3 or Et3N in very high yields. The reaction of aryl, alkyl, aliphatic, and hindered thiols with various alkyl halides gave the corresponding products with significant advantages such as high conversions, short reaction time, mild reaction conditions, and low cost, simple workup with good to quant. yields. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Product Details of 53136-21-3

The Article related to thiol alkyl halide alkylation water, thioether green preparation, General Organic Chemistry: Synthetic Methods and other aspects.Product Details of 53136-21-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem