On February 29, 2020, Song, Song; Li, Xinyao; Wei, Jialiang; Wang, Weijin; Zhang, Yiqun; Ai, Lingsheng; Zhu, Yuchao; Shi, Xiaomeng; Zhang, Xiaohui; Jiao, Ning published an article.Quality Control of 1,4-Dimethoxybenzene The title of the article was DMSO-catalysed late-stage chlorination of (hetero)arenes. And the article contained the following:
A highly efficient aromatic chlorination of arenes such as 1-methyl-indazole, imidazo[1,2-a]pyrazine, phenylthiophene, anthracene, etc. that is catalyzed by DMSO with N-chlorosuccinimide as the chloro source is reported. The mild conditions, easy-availability and stability of the catalyst and reagents, as well as good functional-group tolerance, showed the approach to be a versatile protocol for the late-stage aromatic chlorination of complex natural products, e.g., papaverine, drugs, e.g., diclofenac and peptides, e.g., I. The multi-gram experiment and low-cost of N-chlorosuccinimide and DMSO show great potential for drug discovery and development in industrial applications. The experimental process involved the reaction of 1,4-Dimethoxybenzene(cas: 150-78-7).Quality Control of 1,4-Dimethoxybenzene
The Article related to arene heteroarene chlorination dimethyl sulfoxide catalyst, General Organic Chemistry: Synthetic Methods and other aspects.Quality Control of 1,4-Dimethoxybenzene
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