Month: November 2022

On May 20, 2016, Li, Pengfei; Weng, Yunxiang; Xu, Xianxiang; Cui, Xiuling published an article.Application of 157869-15-3 The title of the article was Access to Indole Derivatives from Diaryliodonium Salts and 2-Alkynylanilines. And the article contained the following:

An efficient, environmentally friendly, and operationally simple procedure to 1,2-disubstituted indoles from 2-alkynylanilines and diaryliodonium salts has been developed. This reaction proceeds smoothly under metal-free conditions. The products obtained could be transferred into 3,3′-diindolylmethane with DMSO catalyzed by palladium. The isotopic label experiments indicated that the methylene group in 3,3′-diindolylmethane is derived from DMSO. The diverse indoles were obtained in up to 90% yield for 28 examples. The experimental process involved the reaction of 2-((4-Methoxyphenyl)ethynyl)aniline(cas: 157869-15-3).Application of 157869-15-3

The Article related to indole preparation green chem, alkynylaniline diaryliodonium salt, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 157869-15-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On April 30, 2022, Ali, Hadi; Vandevyvere, Tom; Lauwaert, Jeroen; Kansal, Sushil Kumar; Saravanamurugan, Shunmugavel; Thybaut, Joris W. published an article.Quality Control of 2-Methylanisole The title of the article was Impact of oxygen vacancies in Ni supported mixed oxide catalysts on anisole hydrodeoxygenation. And the article contained the following:

The hydrodeoxygenation (HDO) activity of anisole has been investigated over Ni catalysts on mixed metal oxide supports containing Nb-Zr and Ti-Zr in 1:1 and 1:4 ratios. XRD patterns indicate the incorporation of Ti (or Nb) into the ZrO2 framework. XPS and oxygen pulse chemisorption analyses reveal that Ni/Ti1Zr4 and Ni/Nb1Zr4 possessed more oxygen vacancy sites than Ni/Ti1Zr1 and Ni/Nb1Zr1, resp. Correspondingly, the HDO activity of Ni/Ti1Zr4 and Ni/Nb1Zr4 was higher with an anisole conversion up to 30.7 and 34.4%, with high selectivity towards benzene (up to 64.7 and 63.3%), compared to corresponding Ni/Ti1Zr1 and Ni/Nb1Zr1 catalysts. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Quality Control of 2-Methylanisole

The Article related to oxygen nickel supported oxide catalyst anisole hydrodeoxygenation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Quality Control of 2-Methylanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On January 17, 1997, Commercon, Alain; Lebrun, Alain; Mailliet, Patrick; Peyronel, Jean Francois; Sounigo, Fabienne; Truchon, Alain; Zucco, Martine; Cheve, Michel published a patent.SDS of cas: 81616-80-0 The title of the patent was New benzisoindole derivatives as inhibitors of farnesyl transferase, their preparation, and pharmaceutical compositions containing them.. And the patent contained the following:

Title compounds I [R = (un)substituted (CH2)mX1(CH2)nZ; X1 = bond, O, S; m = 0-1; n = 0-2; Z = CO2H, alkoxycarbonyl, (un)substituted carbamoyl, etc.; R1, R2 = H, halo, alkyl, (un)substituted alkoxy; or R1R2 form (un)saturated heterocycle; or R2 forms dimer via disulfide bridge; R3 = H, halo, alkyl, alkenyl, alkoxy, alkylthio; X = O, S, NH, CO, CH2, CH2CH2, alkylene, 1,1-cycloalkanediyl; Y = O, S], in racemic form or as optical isomers, are claimed. The compounds are inhibitors of farnesyl transferase, and show marked antitumor and antileukemic properties. For example, cis-3,6-diphenyl-1,4-cyclohexadienecarboxylic acid Me ester (preparation given) reacted with PhCH2N(CH2OBu)(CH2SiMe3) in refluxing CF3CO2H to give the intermediate hexahydroisoindole derivative II.HCl, which was further cyclized by CF3SO3H at 5-20�to give the benz[f]isoindole intermediate III. This was then converted in 3 steps to title compound IV. In an assay for inhibition of farnesyl transferase, IV had an IC50 of 0.31 渭M. The experimental process involved the reaction of (S)-2-(2-Methoxyphenyl)propanoic acid(cas: 81616-80-0).SDS of cas: 81616-80-0

The Article related to benzisoindole preparation farnesyl transferase inhibitor antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 81616-80-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On October 9, 2008, Tomoo, Toshiyuki; Nakatsuka, Takashi; Hayashi, Yasuhiro; Katayama, Toyoko published a patent.Safety of Benzyl(4-bromophenyl)sulfane The title of the patent was Preparation of indole derivatives as cytosolic phospholipase A2 (cPLA2) inhibitors. And the patent contained the following:

The title compounds I [R1 = (un)substituted aromatic hydrocarbon group, (un)substituted aromatic heterocyclic group containing 1 – 4 heteroatoms (N, S, O), etc.; R2 = H, alkyl, cycloalkyl, etc.; R3 = (un)substituted aromatic hydrocarbon group, (un)substituted aromatic heterocyclic group containing 1 – 4 heteroatoms (N, S, O); R4 = cyano, tetrazole, isothiazole, etc.; X1 = carbonyl, methylene; X2 = alkylene, bond; X3 = alkylene, alkenylene, alkynylene] are prepared (2E)-3-(3-Benzoyl-1-phenyl-1H-indol-5-yl)-2-propenoic acid was prepared in a multistep process starting from 5-bromoindole and iodobenzene. Compounds of this invention showed IC50 values of 0.002 渭M to 21.3 渭M against cPLA2. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Safety of Benzyl(4-bromophenyl)sulfane

The Article related to indole derivative preparation cytosolic phospholipase a2 inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of Benzyl(4-bromophenyl)sulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cheng, Faxiang; Ma, Haihong; Ren, Fengmei; Ouyang, Gaoyuan; Zhou, Zhengfa; Xu, Weibing published an article in 2010, the title of the article was Poly(2-methoxy-5-(2′-ethylhexyloxy)-p-phenylene vinylene) synthesized by bromine methylation.Product Details of 146370-51-6 And the article contains the following content:

Poly[2-methoxy-5-(2′-ethylhexyloxy)-p-phenylene vinylene] (MEH-PPV) was successfully synthesized using p-methoxy phenol and 1-bromo-2-ethylhexane through the reactions of etherification, bromine methylation and de-hydrogen bromide. The number average mol. weight of MEH-PPV was 5.7è„?04. The structure of intermediates and MEH-PPV were characterized by FTIR, 1HNMR and UV-Vis. The structure of intermediates and MEH-PPV was consistent with the reported in the literature. The experimental process involved the reaction of 1-((2-Ethylhexyl)oxy)-4-methoxybenzene(cas: 146370-51-6).Product Details of 146370-51-6

The Article related to methoxyethylhexyloxyphenylene vinylene bromine methylation synthesis, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Product Details of 146370-51-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 6, 2020, Pfister, Patrick; Smith, Benjamin C.; Evans, Barry J.; Brann, Jessica H.; Trimmer, Casey; Sheikh, Mushhood; Arroyave, Randy; Reddy, Gautam; Jeong, Hyo-Young; Raps, Daniel A.; Peterlin, Zita; Vergassola, Massimo; Rogers, Matthew E. published an article.Category: ethers-buliding-blocks The title of the article was Odorant Receptor Inhibition Is Fundamental to Odor Encoding. And the article contained the following:

Most natural odors are complex mixtures of volatile components, competing to bind odorant receptors (ORs) expressed in olfactory sensory neurons (OSNs) of the nose. To date, surprisingly little is known about how OR antagonism shapes neuronal representations in the detection layer of the olfactory system. Here, we investigated its prevalence, the degree to which it disrupts OR ensemble activity, and its conservation across phylogenetically related ORs. Calcium imaging microscopy of dissociated OSNs revealed significant inhibition, often complete attenuation, of responses to indole – a commonly occurring volatile associated with both floral and fecal odors-by a set of 36 tested odorants. To confirm an OR mechanism for the observed inhibition, we performed single-cell transcriptomics on OSNs exhibiting specific response profiles to a diagnostic panel of odorants and identified three paralogous receptors – Olfr740, Olfr741, and Olfr743 – which, when tested in vitro, recapitulated OSN responses. We screened ten ORs from the Olfr740 gene family with âˆ?00 perfumery-related odorants spanning a range of chem. scaffolds and functional groups. Over half of these compounds (430) antagonized at least one of the ten ORs. OR activity fitted a math. model of competitive receptor binding and suggests normalization of OSN ensemble responses to odorant mixtures is the rule rather than the exception. In summary, we observed OR antagonism occurred frequently and in a combinatorial manner. Thus, extensive receptor-mediated computation of mixture information appears to occur in the olfactory epithelium prior to transmission of odor information to the olfactory bulb. The experimental process involved the reaction of 2-Methoxynaphthalene(cas: 93-04-9).Category: ethers-buliding-blocks

The Article related to odor odorant receptor inhibition olfactory epithelium, g protein-coupled, antagonism, odor mixtures, odorant, olfaction, receptor, sensory neurons, Mammalian Biochemistry: General Physiological Chemistry and other aspects.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jiang, Yihui; Wang, Chunlan; Ma, Nana; Chen, Jie; Liu, Chuanfei; Wang, Fang; Xu, Jiakun; Cong, Zhiqi published an article in 2020, the title of the article was Regioselective aromatic O-demethylation with an artificial P450BM3 peroxygenase system.Electric Literature of 578-58-5 And the article contains the following content:

Several simple single- and double-mutants of cytochrome P450BM3 enzymes enabled a highly regioselective O-demethylation of aromatic ethers with H2O2 with the assistance of a dual-functional small mol. (DFSM). The DFSM-facilitated P450BM3 peroxygenase system provides an alternative, simple approach for a key step in the bioconversion of lignin compared with reported NADPH-dependent P 450 monooxygenases. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Electric Literature of 578-58-5

The Article related to regioselective aromatic o demethylation engineering cytochrome p450bm3 peroxygenase, Fermentation and Bioindustrial Chemistry: Macromolecules and other aspects.Electric Literature of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On July 31, 2021, Wong, Warren H. L.; Gries, Regine M.; Abram, Paul K.; Alamsetti, Santosh K.; Gries, Gerhard published an article.Electric Literature of 578-58-5 The title of the article was Attraction of Brown Marmorated Stink Bugs, Halyomorpha halys, to Blooming Sunflower Semiochemicals. And the article contained the following:

The polyphagous invasive brown marmorated stink bug, Halyomorpha halys, reportedly discriminates among phenol. stages of host plants. To determine whether olfaction is involved in host plant stage discrimination, we selected (dwarf) sunflower, Helianthus annuus, as a model host plant species. When adult females of a still-air laboratory experiment were offered a choice of four potted sunflowers at distinct phenol. stages (vegetative, pre-bloom, bloom, seeding), most females settled onto blooming plants but oviposited evenly on plants of all four stages. In moving-air two-choice olfactometer experiments, we then tested each plant stage vs. filtered air and vs. one another, for attraction of H. halys females. Blooming sunflowers performed best overall, but no one plant stage was most attractive in all experiments Capturing and analyzing (by GC-MS) the headspace odorants of each plant stage revealed a marked increase of odorant abundance (e.g., monoterpenes) as plants transitioned from pre-bloom to bloom. Analyzing the headspace odorant blend of blooming sunflower by gas chromatog.-electroantennog. detection (GC-EAD) revealed 13 odorants that consistently elicited responses from female H. halys antennae. An 11-component synthetic blend of these odorants attracted H. halys females in laboratory olfactometer experiments Furthermore, in field settings, the synthetic blend enhanced the attractiveness of synthetic H. halys pheromone as a trap lure, particularly in spring (Apr. to mid-June). A simpler yet fully effective sunflower semiochem. blend could be developed and coupled with synthetic H. halys aggregation pheromones to improve monitoring efforts or could improve the efficacy of modified attract-and-kill control tactics for H. halys. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Electric Literature of 578-58-5

The Article related to halyomorpha halys blooming sunflower semiochem, gc-ead, gc–ms, olfactometer bioassays, pentatomidae, plant phenology, plant volatile compounds, Agrochemical Bioregulators: Methods (Including Analysis) and other aspects.Electric Literature of 578-58-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Verevkin, Sergey P.; Turovtsev, Vladimir V.; Andreeva, Irina V.; Orlov, Yurij D.; Pimerzin, Aleksey A. published an article in 2021, the title of the article was Webbing a network of reliable thermochemistry around lignin building blocks: tri-methoxy-benzenes.Formula: C8H10O And the article contains the following content:

Methoxy-substituted benzenes are the simplest fragments from the lignin separation feedstock. Extensive exptl. thermochem. studies of these compounds were carried out, including vapor pressure measurements, combustion and differential scanning calorimetry. These data were evaluated using empirical, semi-empirical and quantum chem. methods. The consistent sets of evaluated thermodn. data were used to design the method for predicting enthalpies of vaporization and enthalpies of formation of di- and tri-substituted benzenes. It has been found that the agglomeration of substituents on the benzene ring has dramatic consequences for the energetics of the mol. (in terms of the enthalpy of formation), as well as for the energetics of intermol. interactions (in terms of the enthalpy of vaporization). These observations are essential to reliably assess the energetics of the mols. that appear in reaction products of lignin transformations in value-adding chems. and materials. The experimental process involved the reaction of 2-Methylanisole(cas: 578-58-5).Formula: C8H10O

The Article related to lignin building block thermochem, Cellulose, Lignin, Paper, and Other Wood Products: Lignin and other aspects.Formula: C8H10O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kusumoto, Shuhei; Kishino, Masamichi; Nozaki, Kyoko published an article in 2020, the title of the article was Cleavage of C-C and C-O Bonds in β-O-4 Linkage of Lignin Model Compound by Cyclopentadienone Group 8 and 9 Metal Complexes.COA of Formula: C8H10O2 And the article contains the following content:

Degradation of 1-(3,4-dimethoxyphenyl)-2-(2-methoxyphenoxy)propane-1,3-diol (1), a model compound for lignin β-O-4 linkage was examined with iron, ruthenium, rhodium and iridium complexes bearing cyclopentadienone ligand. Cyclopentadienone iron complex gave only a small amount of degraded product with reduced mol. weight Cyclopentadienone ruthenium complex, so called Shvo’s catalyst, afforded 3,4-dimethoxybenzaldehyde (a3) in 14.3% yield after Cα-Cβ bond cleavage. On the other hand, cyclopentadienone group-9 metal complexes catalyzed Cβ-O bond cleavage to afford guaiacol (b1) as a main product in up to 74.9% yield. The experimental process involved the reaction of 1,2-Dimethoxybenzene(cas: 91-16-7).COA of Formula: C8H10O2

The Article related to lignin metal ligand cooperation retro aldol reaction, Cellulose, Lignin, Paper, and Other Wood Products: Lignin and other aspects.COA of Formula: C8H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem