On October 9, 2008, Tomoo, Toshiyuki; Nakatsuka, Takashi; Hayashi, Yasuhiro; Katayama, Toyoko published a patent.Safety of Benzyl(4-bromophenyl)sulfane The title of the patent was Preparation of indole derivatives as cytosolic phospholipase A2 (cPLA2) inhibitors. And the patent contained the following:
The title compounds I [R1 = (un)substituted aromatic hydrocarbon group, (un)substituted aromatic heterocyclic group containing 1 – 4 heteroatoms (N, S, O), etc.; R2 = H, alkyl, cycloalkyl, etc.; R3 = (un)substituted aromatic hydrocarbon group, (un)substituted aromatic heterocyclic group containing 1 – 4 heteroatoms (N, S, O); R4 = cyano, tetrazole, isothiazole, etc.; X1 = carbonyl, methylene; X2 = alkylene, bond; X3 = alkylene, alkenylene, alkynylene] are prepared (2E)-3-(3-Benzoyl-1-phenyl-1H-indol-5-yl)-2-propenoic acid was prepared in a multistep process starting from 5-bromoindole and iodobenzene. Compounds of this invention showed IC50 values of 0.002 渭M to 21.3 渭M against cPLA2. The experimental process involved the reaction of Benzyl(4-bromophenyl)sulfane(cas: 53136-21-3).Safety of Benzyl(4-bromophenyl)sulfane
The Article related to indole derivative preparation cytosolic phospholipase a2 inhibitor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of Benzyl(4-bromophenyl)sulfane
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